Magnetocaloric effect in hexacyanochromate Prussian blue analogs

We report on the magnetocaloric properties of two molecule-based hexacyanochromate Prussian blue analogs, nominally CsNi[Cr(CN)_6](H_2O) and Cr_3[Cr(CN)_6]_2x12(H_2O). The former orders ferromagnetically below Tc=90 K, whereas the latter is a ferrimagnet below Tc=230 K. For both, we find significantly large magnetic entropy changes DSm associated to the magnetic phase transitions. Notably, our studies represent the first attempt to look at molecule-based materials in terms of the magnetocaloric effect for temperatures well above the liquid helium range.Comment: 4 pages, 6 figure

Ground state of the spin-1/2 chain of green dioptase at high fields

The gem-stone dioptase Cu6Si6O18.6H2O has a chiral crystal structure of equilateral triangular helices consisting of Cu-3d spins. It shows an antiferromagnetic order with an easy axis along c at TN = 15.5 K under zero field, and a magnetization jump at HC = 13.5 T when the field is applied along c-axis. By 29Si-NMR measurements, we have revealed that the high-field state is essentially the two sub-lattice structure, and that the component within ab-plane is collinear. The result indicates no apparent match with the geometrical pattern of helical spin chain.Comment: SCES2013, Hongo, Toky

一抗体免疫法によるPorphyromonas. gingivalis SODの定量(プレリミナリーレポート)

Superoxide dismutase (SOD) as a free radical scavenger in Porphyromonas gingivalis is well documented. The aim of this work was to develop an enzyme-linked immunosorbent assay using recombinant P. gingivalis SOD as an antigen. The sandwich complex was detected using a secondary antibody conjugated to β-D-galactosidase. Under optimum conditions, the sensitivity and the limit of detection were determined from 25pg to 500pg. In future, the application will be extended to the expression of SOD from P. gingivalis under various growing conditions

Pre-hospital advanced airway management for adults with out-of-hospital cardiac arrest: Nationwide cohort study

Objective To determine survival associated with advanced airway management (AAM) compared with no AAM for adults with out-of-hospital cardiac arrest. Design Cohort study between January 2014 and December 2016. Setting Nationwide, population based registry in Japan (All-Japan Utstein Registry). Participants Consecutive adult patients with out-of-hospital cardiac arrest, separated into two sub-cohorts by their first documented electrocardiographic rhythm: shockable (ventricular fibrillation or pulseless ventricular tachycardia) and non-shockable (pulseless electrical activity or asystole). Patients who received AAM during cardiopulmonary resuscitation were sequentially matched with patients at risk of AAM within the same minute on the basis of time dependent propensity scores. Main outcome measures Survival at one month or at hospital discharge within one month. Results Of the 310 620 patients eligible, 8459 (41.2%) of 20 516 in the shockable cohort and 121 890 (42.0%) of 290 104 in the non-shockable cohort received AAM during cardiopulmonary resuscitation. After time dependent propensity score sequential matching, 16 114 patients in the shockable cohort and 236 042 in the non-shockable cohort were matched at the same minute. In the shockable cohort, survival did not differ between patients with AAM and those with no AAM: 1546/8057 (19.2%) versus 1500/8057 (18.6%) (adjusted risk ratio 1.00, 95% confidence interval 0.93 to 1.07). In the non-shockable cohort, patients with AAM had better survival than those with no AAM: 2696/118 021 (2.3%) versus 2127/118 021 (1.8%) (adjusted risk ratio 1.27, 1.20 to 1.35). Conclusions In the time dependent propensity score sequential matching for out-of-hospital cardiac arrest in adults, AAM was not associated with survival among patients with shockable rhythm, whereas AAM was associated with better survival among patients with non-shockable rhythm.Izawa Junichi, Komukai Sho, Gibo Koichiro, Okubo Masashi, Kiyohara Kosuke, Nishiyama Chika et al. Pre-hospital advanced airway management for adults with out-of-hospital cardiac arrest: nationwide cohort study. BMJ 2019; 364 :l43

In vitro Activities of Oral Cephem and Telithromycin Against Clinical Isolates of Major Respiratory Pathogens in Japan

The in vitro antibacterial activities of oral cephem antibiotics and ketolide telithromycin against major respiratory pathogens possessing β-lactam-resistant mutations (within the pbp gene) and/or macrolide-resistant genes (erm and mef) were examined in clinical isolates collected at 66 institutes in all over the Japan between 2002 and 2003. Telithromycin showed the strongest antibacterial activity against methicillin-susceptible Staphylococcus aureus strains with and without macrolide-resistant genes, such as ermA or ermC gene. All the cephem antibiotics showed potent antibacterial activity against Streptococcus pyogenes, with minimum inhibitory concentrations (MICs) of 0.015 mg/L or lower. Cefdinir had a much higher MIC90 against genotypic penicillin-resistant Streptococcus pneumoniae (gPRSP) than cefditoren and cefcapene (8 mg/L cefdinir vs. 1 mg/L cefditoren and cefcapene). The majority of gPRSP harbored either ermB or mefA, and the antibacterial activity of telithromycin against these strains was decreased however some susceptibility was still sustained. Cefditoren exerted the strongest antibacterial activity against β-lactamase-negative ampicillin-resistant Haemophilus influenzae, with an MIC90 of 0.5 mg/L. These results underline the importance of checking the susceptibility and selecting an appropriate antibiotic against target pathogens

Team Characteristics for Maximizing the Educational Effectiveness of Practical Lectures on Software Intensive Systems Development

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Large Direct CP Violation in B -> phi phi Xs Decays

We present a novel method to search for a new CP-violating phase in b -> ss~ss~s transition using B -> phi phi Xs decays, where Xs represents a final state with a specific strange flavor such as K+/-, K*+/-, or K+/-pi-/+. Direct CP violation can be enhanced due to an interference between an amplitude beyond the standard model (SM) and the SM decay amplitude through the eta_c resonance. We find that the CP asymmetry can be as large as 0.4 within the present experimental bounds on the b -> ss~s transition. These decays provide a very clean experimental signature and the background is expected to be small in particular at e+e- B factories. A simulation study for the B+/- -> phi phi K+/- decay shows that the statistical significance of CP violation can exceed 5 standard deviations with 10^9 B mesons.Comment: 12 pages, 2 figures, to appear in Physics Letters

Out-of-hospital Cardiac Arrest across the World: First Report from the International Liaison Committee on Resuscitation (ILCOR)

Background Since development of the Utstein style recommendations for the uniform reporting of cardiac arrest, increasing numbers of national and regional out-of-hospital cardiac arrest (OHCA) registries have been established worldwide. The International Liaison Committee on Resuscitation (ILCOR) created the Research and Registries Working Group and aimed to systematically report data collected from these registries. Methods We conducted two surveys of voluntarily participating national and regional registries. The first survey aimed to identify which core elements of the current Utstein style for OHCA were collected by each registry. The second survey collected descriptive summary data from each registry. We chose the data collected for the second survey based on the availability of core elements identified by the first survey. Results Seven national and four regional registries were included in the first survey and nine national and seven regional registries in the second survey. The estimated annual incidence of emergency medical services (EMS)-treated OHCA was 30.0 to 97.1 individuals per 100,000 population. The combined data showed the median age varied from 64 to 79 years and more than half were male in all 16 registries. The provision of bystander cardiopulmonary resuscitation (CPR) and bystander automated external defibrillator (AED) use was 19.1% to 79.0% in all registries and 2.0% to 37.4% among 11 registries, respectively. Survival to hospital discharge or 30-day survival after EMS-treated OHCA was 3.1% to 20.4% across all registries. Favourable neurological outcome at hospital discharge or 30 days after EMS-treated OHCA was 2.8% to 18.2%. Survival to hospital discharge or 30-day survival after bystander witnessed shockable OHCA ranged from 11.7% to 47.4% and favourable neurological outcome from 9.9% to 33.3%. Conclusion This report from ILCOR describes data on systems of care and outcomes following OHCA from nine national and seven regional registries across the world. We found variation in reported survival outcomes and other core elements of the current Utstein style recommendations for OHCA across nations and regions.Peer reviewe