Dimensions, septation, and pattern of pneumatization of the sphenoidal sinus

The endoscopic endonasal transsphenoidal approach (EEA) to treat sellar, parasellar, and suprasellar tumours continues to gain increased significance. Due to the close proximity of the sphenoid sinus to the carotid artery and the optic canal, it is very important for surgeons to know the anatomical features and variations of the sphenoid sinus as relevant to EEA. A prospective study of the sphenoid sinus morphology was carried out on the cranial tomographic (CT) scan images of 60 Nigerian adult patients. The CTs were reviewed regarding the different anatomical variations of the sphenoid sinus: dimensions, septation, and pattern of pneumatisation. There were 37 males and 23 females. The patients’ ages ranged from 18 years to 85 years, with a mean of 47.2 years. There was a main single intersphenoid septum in most patients (95%). The insertion of the septum was usually to the right posteriorly (38%) and in the midline anterior (65%). Although there is usually a main septum, the septa present were multiple in 29 of the sinuses studied. There was no gender difference with respect to the attachment of the main sphenoid sinus septum. The sphenoid anterior, posterior, and transverse dimensions were not significantly dependent on age, but they were longer in males than in females. Sellar pneumatization was present in the majority of the patients (83%), with 4 patients having postsellar pneumatization (6.7%) and 3 patients having presellar pneumatization (5%).There were no cases with conchal pneumatization or lateral pneumatization of the greater wing of the sphenoid. The present study provides anatomical information about the sphenoid sinus dimensions morphology that is essential for avoiding complications in performing an endoscopic sphenoidotomy

Responses of selected inflammatory, kidney and liver function markers in Serum of Nigerian Children with Severe Falciparum Malaria to treatment with artesunate/artemether-lumefantrine combination therapy

Malaria tolerance is a defence strategy that limits the damage caused by Plasmodium species irrespective of pathogen burden. The mechanisms responsible for this, responses of these mechanisms and their impact on organs to treatment have not been extensively studied. Thus, in this study, serum levels of selected pro- and anti-inflammatory markers, liver and kidney function indices with leucocytes indices in 100 children (1-10 years) with severe falciparum malaria were determined before treatment, at 48 hours during treatment and 48 hours after treatment with WHO recommended dosage of artesunate/artemether-lumefantrine combination therapy using standard methods. Data were analysed using SPSS, differences were considered significant at p<0.05. The results revealed that the serum levels of interleukin-12 (IL-12), interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), C-reactive protein (CRP), nitric oxide (NO), creatinine, albumin, total protein and conjugated bilirubin were not significantly changed at higher parasite densities before treatment. Only serum IL-4, CRP, total bilirubin, urea and creatinine levels and alanine aminotransferase activity were significantly reduced below the ranges of those with severe malaria. The results suggest a self-protective feed-back control, indicating tolerance, which reduced the adverse effects of the disease on kidney and liver functions at higher parasite densities. The results also suggest serum IL-12, IL-4, TNF-α, IFN-γ, CRP and NO levels as immune-protective markers for tolerance and serum IL-4 level as an effective marker for disease severity and recovery from the disease in children with severe malariaKeywords: Immunity, falciparum malaria, inflammatory markers, childrenAfr. J. Biomed. Res. Vol. 22 (May, 2019); 165-17

Fruit and Vegetable Crop Production in Nigeria: The Gains, Challenges and The Way Forward

The major fruits produced in Nigeria include mango, pineapple, plantain/banana, citrus, guava, pawpaw, while vegetables include onion, tomato, okra, pepper, amaranthus, carrot, melon, Corchorus olitorus (ewedu), Hibiscus sabdariffa (sobo), Adansonia digtata (baobab leaves) etc. In Nigeria, enormous quantities of fruits and vegetables are produced and staggering figures are sometimes given as estimated annual production .Fruits and vegetables play a very important role in the nutrition and health especially as they contain substances which regulate or stimulate digestion, act as laxatives or diuretics, pectins and phenoic compounds which play a part in regulating the pH of the intestines. Fruits and vegetables also contribute to the income of both the rural and urban dweller. The industrial potential of many fruits and vegetables available in Nigeria is enormous. What Nigerians need to do is embark on massive production of these fruits and vegetables not only for their high nutritive value but for enhancing the establishment of many processing industries. The development of their industrial uses will stimulate large scale production of the crops and enhanced diversification of entrepreneur to site processing plants in the rural areas which will improve the quality of life of the rural population and reduce the rate of rural-urban migration Fruits and vegetable production in Nigeria is a serious business because it provides a means of livelihood for some people and also play an important role in the improvement of the health of Nigerian

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Reproductive traits of male weaner rabbits fed graded levels of Garcinia Kola (bitter kola)

An experiment was conducted to determine the effect of Garcinia kola on the reproductive traits of male rabbits. Twenty four (24) male rabbits of about 1.0+0.46kg were randomly assigned into four (4) treatment groups. Treatment one (T1) had 0% Garcinia kola, while T2 had 2.5% Garcinia kola and Treatment three and four (T3 and T4) had 5% and 7.5% respectively. There were significant difference (p<0.05) on all parameters measured. Sperm concentration, sperm count and libido were highest in T4 when compared to other treatments. In fact bitter kola supplemented diets were better (p< 0.05) in terms of semen volume sperm concentration, motility and count. The percentage live sperm though differed (p<0.05) significantly did not take a definite pattern that can be attributed to toxic effect of chemical component of bitter kola.Keywords: Bitter kola, male rabbits, sperm, libido

Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities.

The investigation of inherited disorders of erythropoiesis has elucidated many of the principles underlying the production of normal red blood cells and how this is perturbed in human disease. Congenital Dyserythropoietic Anaemia type 1 (CDA-I) is a rare form of anaemia caused by mutations in two genes of unknown function: CDAN1 and CDIN1 (previously called C15orf41), whilst in some cases, the underlying genetic abnormality is completely unknown. Consequently, the pathways affected in CDA-I remain to be discovered. To enable detailed analysis of this rare disorder we have validated a culture system which recapitulates all of the cardinal haematological features of CDA-I, including the formation of the pathognomonic 'spongy' heterochromatin seen by electron microscopy. Using a variety of cell and molecular biological approaches we discovered that erythroid cells in this condition show a delay during terminal erythroid differentiation, associated with increased proliferation and widespread changes in chromatin accessibility. We also show that the proteins encoded by CDAN1 and CDIN1 are enriched in nucleoli which are structurally and functionally abnormal in CDA-I. Together these findings provide important pointers to the pathways affected in CDA-I which for the first time can now be pursued in the tractable culture system utilised here

Call for action: Designing for harmony in creative teams

Competitive markets force diverse organizations to intensively manage innovation. Many of them set up multifunctional teams responsible for generating novel and original ideas. Such teams often face higher risk of conflicts and tensions, being an inherent part of creative processes. Impact of this phenomena on creative performance of teams, even though extensively addressed in research, remains unclarified. We approach this issue while providing a novel interpretation framework inspired by the concept of harmony in jazz improvisation. We apply it to observations made with project teams in an organizational setting, and use it to inform design of a supporting collaborative solution. We postulate the need for further work on team harmony and creativity