Screening for the Hypoglycaemic Potentials of the Extract of Vernonia amyggalina

This work evaluates the hypoglycemic effect of Vernonia amygdalina on alloxan induced diabetic rats. Different doses of the aqueous leaf extract of Vernonia amygdalina (50mg/kg, 100mg/kg, 200mg/kg and 400mg/kg) were administered to alloxan induced diabetic rats under experimental conditions. The mean fasting blood sugar levels of the groups of diabetic rats increased significantly as it rose from basal blood sugar levels (mg/dl) of 38.0, 39.2, 35.2 and 35.8 to fasting blood sugar levels (mg/dl) of 277.6, 284.8, 256.4 and 265.6. The findings showed that there is a dose dependent reduction in fasting blood sugar in alloxan induced diabetic rats after treatment to 167.5mg/dl, 140.8mg/dl, 104.2mg/dl and 80.4mg/ dl respectively