Dynamical and stationary critical behavior of the Ising ferromagnet in a thermal gradient

In this paper we present and discuss results of Monte Carlo numerical simulations of the two-dimensional Ising ferromagnet in contact with a heat bath that intrinsically has a thermal gradient. The extremes of the magnet are at temperatures $T_1<T_c<T_2$, where $T_c$ is the Onsager critical temperature. In this way one can observe a phase transition between an ordered phase ($TT_c$) by means of a single simulation. By starting the simulations with fully disordered initial configurations with magnetization $m\equiv 0$ corresponding to $T=\infty$, which are then suddenly annealed to a preset thermal gradient, we study the short-time critical dynamic behavior of the system. Also, by setting a small initial magnetization $m=m_0$, we study the critical initial increase of the order parameter. Furthermore, by starting the simulations from fully ordered configurations, which correspond to the ground state at T=0 and are subsequently quenched to a preset gradient, we study the critical relaxation dynamics of the system. Additionally, we perform stationary measurements ($t\rightarrow\infty$) that are discussed in terms of the standard finite-size scaling theory. We conclude that our numerical simulation results of the Ising magnet in a thermal gradient, which are rationalized in terms of both dynamic and standard scaling arguments, are fully consistent with well established results obtained under equilibrium conditions

Dynamic Approach to the Fully Frustrated XY Model

Using Monte Carlo simulations, we systematically investigate the non-equilibrium dynamics of the chiral degree of freedom in the two-dimensional fully frustrated XY model. The critical initial increase of the staggered chiral magnetization is observed. By means of the short-time dynamics approach, we estimate the second order phase transition temperature $T_{c}$ and all the dynamic and static critical exponents $\theta$, z, $\beta$ and $\nu$.Comment: 5 pages with 6 figures include

Dynamic Simulations of the Kosterlitz-Thouless Phase Transition

Based on the short-time dynamic scaling form, a novel dynamic approach is proposed to tackle numerically the Kosterlitz-Thouless phase transition. Taking the two-dimensional XY model as an example, the exponential divergence of the spatial correlation length, the transition temperature $T_{KT}$ and all critical exponents are computed. Compared with Monte Carlo simulations in equilibrium, we obtain data at temperatures nearer to $T_{KT}$.Comment: to appear in Phys. Rev. E in Rapid Communicatio

Human Hepatocyte Growth Factor Promotes Functional Recovery in Primates after Spinal Cord Injury

Many therapeutic interventions for spinal cord injury (SCI) using neurotrophic factors have focused on reducing the area damaged by secondary, post-injury degeneration, to promote functional recovery. Hepatocyte growth factor (HGF), which is a potent mitogen for mature hepatocytes and a mediator of the inflammatory responses to tissue injury, was recently highlighted as a potent neurotrophic factor in the central nervous system. We previously reported that introducing exogenous HGF into the injured rodent spinal cord using a herpes simplex virus-1 vector significantly reduces the area of damaged tissue and promotes functional recovery. However, that study did not examine the therapeutic effects of administering HGF after injury, which is the most critical issue for clinical application. To translate this strategy to human treatment, we induced a contusive cervical SCI in the common marmoset, a primate, and then administered recombinant human HGF (rhHGF) intrathecally. Motor function was assessed using an original open field scoring system focusing on manual function, including reach-and-grasp performance and hand placement in walking. The intrathecal rhHGF preserved the corticospinal fibers and myelinated areas, thereby promoting functional recovery. In vivo magnetic resonance imaging showed significant preservation of the intact spinal cord parenchyma. rhHGF-treatment did not give rise to an abnormal outgrowth of calcitonin gene related peptide positive fibers compared to the control group, indicating that this treatment did not induce or exacerbate allodynia. This is the first study to report the efficacy of rhHGF for treating SCI in non-human primates. In addition, this is the first presentation of a novel scale for assessing neurological motor performance in non-human primates after contusive cervical SCI

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc.

Despite the high prevalence of intervertebral disc disease, little is known about changes in intervertebral disc cells and their regenerative potential with ageing and intervertebral disc degeneration. Here we identify populations of progenitor cells that are Tie2 positive (Tie2+) and disialoganglioside 2 positive (GD2+), in the nucleus pulposus from mice and humans. These cells form spheroid colonies that express type II collagen and aggrecan. They are clonally multipotent and differentiated into mesenchymal lineages and induced reorganization of nucleus pulposus tissue when transplanted into non-obese diabetic/severe combined immunodeficient mice. The frequency of Tie2+ cells in tissues from patients decreases markedly with age and degeneration of the intervertebral disc, suggesting exhaustion of their capacity for regeneration. However, progenitor cells (Tie2+GD2+) can be induced from their precursor cells (Tie2+GD2-) under simple culture conditions. Moreover, angiopoietin-1, a ligand of Tie2, is crucial for the survival of nucleus pulposus cells. Our results offer insights for regenerative therapy and a new diagnostic standard

High-precision broad-band linear polarimetry of early-type binaries I. Discovery of variable, phase-locked polarization in HD48099

Aims. We investigate the structure of the O-type binary system HD48099 by measuring linear polarization that arises due to light scattering process. High-precison polarimetry provides independent estimates of the orbital parameters and gives important information on the properties of the system.Methods. Linear polarization measurements of HD48099 in the B, V and R passbands with the high-precision Dipol-2 polarimeter have been carried out. The data have been obtained with the 60 cm KVA (Observatory Roque de los Muchachos, La Palma, Spain) and T60 (Haleakala, Hawaii, USA) remotely controlled telescopes during 31 observing nights. Polarimetry in the optical wavelengths has been complemented by observations in the X-rays with the Swift space observatory.Results. Optical polarimetry revealed small intrinsic polarization in HD48099 with similar to 0.1% peak to peak variation over the orbital period of 3.08 d. The variability pattern is typical for binary systems, showing strong second harmonic of the orbital period. We apply our model code for the electron scattering in the circumstellar matter to put constraints on the system geometry. A good model fit is obtained for scattering of light on a cloud produced by the colliding stellar winds. The geometry of the cloud, with a broad distribution of scattering particles away from the orbital plane, helps in constraining the (low) orbital inclination. We derive from the polarization data the inclination i = 17 degrees +/- 2 degrees and the longitude of the ascending node Omega = 82 degrees +/- 1 degrees of the binary orbit. The available X-ray data provide additional evidence for the existence of the colliding stellar winds in the system. Another possible source of the polarized light could be scattering from the stellar photospheres. The models with circumstellar envelopes, or matter confined to the orbital plane, do not provide good constraints on the low inclination, better than i <= 27 degrees, as is already suggested by the absence of eclipses

Cardiac troponin I levels in canine pyometra

BACKGROUND: Myocardial injury may contribute to unexpected deaths due to pyometra. To detect myocardial damage, measurement of cardiac troponin I (cTnI) is currently the most sensitive and specific method. The aims of the present study were to evaluate presence of myocardial damage in canine pyometra by analysis of cTnI, to explore whether myocardial injury was associated with systemic inflammatory response syndrome (SIRS) and to evaluate whether other clinical or laboratory parameters were associated with cTnI increase. METHODS: Preoperative plasma levels of cTnI were investigated in 58 female dogs with pyometra and 9 controls. The value of physical examination findings, haematological, serum biochemical and pro-inflammatory (CRP and TNF-α) parameters as possible predictors of increased cTnI levels was also evaluated. RESULTS: Seven dogs with pyometra (12%) and one control dog (11%) had increased levels of cTnI. In the pyometra group, the levels ranged between 0.3–0.9 μg l(-1 )and in the control dog the level was 0.3 μg l(-1). The cTnI levels did not differ significantly between the two groups. No cardiac abnormalities were evident on preoperative physical examinations. Four of the pyometra patients died within two weeks of surgery, of which two were examined post mortem. In one of these cases (later diagnosed with myocarditis and disseminated bacterial infection) the cTnI levels increased from 0.9 μg l(-1 )preoperatively to 180 μg l(-1 )the following day when also heart arrhythmia was also detected. The other patient had cTnI levels of 0.7 μg l(-1 )with no detectable heart pathology post mortem. CTnI increase was not associated with presence of SIRS. There was a trend for the association of cTnI increase with increased mortality. No preoperative physical examination findings and few but unspecific laboratory parameters were associated with increased cTnI levels. CONCLUSION: Increased cTnI levels were observed in 12% of the dogs with pyometra. The proportions of dogs with cTnI increase did not differ significantly in the pyometra group compared with the control group. CTnI increase was not associated with presence of SIRS. A trend for association of cTnI increase and mortality was observed. Preoperative physical examination findings and included laboratory parameters were poor predictors of increased cTnI levels

Static Magnetic Field Exposure Reproduces Cellular Effects of the Parkinson's Disease Drug Candidate ZM241385

This study was inspired by coalescing evidence that magnetic therapy may be a viable treatment option for certain diseases. This premise is based on the ability of moderate strength fields (i.e., 0.1 to 1 Tesla) to alter the biophysical properties of lipid bilayers and in turn modulate cellular signaling pathways. In particular, previous results from our laboratory (Wang et al., BMC Genomics, 10, 356 (2009)) established that moderate strength static magnetic field (SMF) exposure altered cellular endpoints associated with neuronal function and differentiation. Building on this background, the current paper investigated SMF by focusing on the adenosine A(2A) receptor (A(2A)R) in the PC12 rat adrenal pheochromocytoma cell line that displays metabolic features of Parkinson's disease (PD).SMF reproduced several responses elicited by ZM241385, a selective A(2A)R antagonist, in PC12 cells including altered calcium flux, increased ATP levels, reduced cAMP levels, reduced nitric oxide production, reduced p44/42 MAPK phosphorylation, inhibited proliferation, and reduced iron uptake. SMF also counteracted several PD-relevant endpoints exacerbated by A(2A)R agonist CGS21680 in a manner similar to ZM241385; these include reduction of increased expression of A(2A)R, reversal of altered calcium efflux, dampening of increased adenosine production, reduction of enhanced proliferation and associated p44/42 MAPK phosphorylation, and inhibition of neurite outgrowth.When measured against multiple endpoints, SMF elicited qualitatively similar responses as ZM241385, a PD drug candidate. Provided that the in vitro results presented in this paper apply in vivo, SMF holds promise as an intriguing non-invasive approach to treat PD and potentially other neurological disorders