Omental leiomyosarcoma with unusual giant cells in a Beagle dog — Short communication

A 10-year-old castrated male Beagle dog was presented with a 2-month history of intermittent vomiting and abdominal pain. The dog was referred to the Veterinary Teaching Hospital at Iwate University for further evaluation, and a splenic tumour was suspected on the basis of ultrasonography and computed tomography. Surgery identified a large, solid, light-pink mass on the greater omentum with blood-coloured ascites in the abdominal cavity, and resection was performed. Microscopically, the mass comprised spindle-shaped tumour cells and scattered osteoclast-like giant cells. Most spindle-shaped cells were positive for vimentin, desmin, and smooth muscle actin (α-SMA), whereas osteoclast-like giant cells were positive only for vimentin. On the basis of histopathological and immunohistochemical findings, a diagnosis of leiomyosarcoma was made. To the best of our knowledge, this represents the first report of leiomyosarcoma associated with osteoclast-like giant cells developing from the greater omentum in a dog

Field-Cooling Effect in the Amorphous Magnetic Oxide

Amorphous magnetic oxides of BaO-Mn_2O_3-B_2O_3 system are prepared by a rapid quenching technique. Magnetic measurements down to 4.2 K reveal weak ferromagnetic components with T_c～50 K. The origin of the ferromagnetism is suggested to be due to manganese-rich clusters arising from concentration fluctuations in the glass. The field-cooling effect in this system is compared with that in the amorphous BaO-Fe_2O_3-B_2O_3 system

Comprehensive genomic characterization of five canine lymphoid tumor cell lines

Abstract Background Leukemia/lymphoma cell lines have been critical in the investigation of the pathogenesis and therapy of hematological malignancies. While human LL cell lines have generally been found to recapitulate the primary tumors from which they were derived, appropriate characterization including cytogenetic and transcriptional assessment is crucial for assessing their clinical predictive value. Results In the following study, five canine LL cell lines, CLBL-1, Ema, TL-1 (Nody-1), UL-1, and 3132, were characterized using extensive immunophenotyping, karyotypic analysis, oligonucleotide array comparative genomic hybridization (oaCGH), and gene expression profiling. Genome-wide DNA copy number data from the cell lines were also directly compared with 299 primary canine round cell tumors to determine whether the cell lines represent primary tumors, and, if so, what subtype each most closely resembled. Conclusions Based on integrated analyses, CLBL-1 was classified as B-cell lymphoma, Ema and TL-1 as T-cell lymphoma, and UL-1 as T-cell acute lymphoblastic leukemia. 3132, originally classified as a B-cell lymphoma, was reclassified as a histiocytic sarcoma based on characteristic cytogenomic properties. In combination, these data begin to elucidate the clinical predictive value of these cell lines which will enhance the appropriate selection of in vitro models for future studies of canine hematological malignancies

Calibrations of Fast Ion Flux Measurement Using a Hybrid Directional Probe

A hybrid directional probe method both “thermal and Langmuir probe” was applied for fast ion measure- ments in the compact helical system. In order to obtain absolute values of fast ion density and power density, a calibration of the probe was performed using neutral hydrogen beam and a mixture beam of hydrogen and proton, of which beam current and energy were controlled. The conversion factor from temperature increase of the probe head to local power density and secondary electron emission yield was obtained. The density of fast ions was obtained by directional thermal probe (DTP) method inside the last closed flux surface, and the density ratio was nFastIon/nBulkPlasma = 2.7 × 10?3 at r/a = 0.9. The observation of the directional Langmuir probe (DLP) method is consistent with the DTP results

NARP-related alterations in the excitatory and inhibitory circuitry of socially isolated mice: developmental insights and implications for autism spectrum disorder

BackgroundSocial isolation during critical periods of development is associated with alterations in behavior and neuronal circuitry. This study aimed to investigate the immediate and developmental effects of social isolation on firing properties, neuronal activity-regulated pentraxin (NARP) and parvalbumin (PV) expression in the prefrontal cortex (PFC), social behavior in juvenile socially isolated mice, and the biological relevance of NARP expression in autism spectrum disorder (ASD).MethodsMice were subjected to social isolation during postnatal days 21–35 (P21–P35) and were compared with group-housed control mice. Firing properties in the PFC pyramidal neurons were altered in P35 socially isolated mice, which might be associated with alterations in NARP and PV expression.ResultsIn adulthood, mice that underwent juvenile social isolation exhibited difficulty distinguishing between novel and familiar mice during a social memory task, while maintaining similar levels of social interaction as the control mice. Furthermore, a marked decrease in NARP expression in lymphoblastoid cell lines derived from adolescent humans with ASD as compared to typically developing (TD) humans was found.ConclusionOur study highlights the role of electrophysiological properties, as well as NARP and PV expression in the PFC in mediating the developmental consequences of social isolation on behavior

頸部リンパ節転移が嚢胞を呈した甲状腺不顕性癌の1例

頸部リンパ節転移が,嚢胞を呈した甲状腺不顕性癌の1例を経験したので報告した.症例31歳男性,左側頸部腫瘤を主訴として来院.側頸部嚢胞と診断したが,摘出腫瘤を組織学的に検討した結果,甲状腺癌のリンパ節転移と判明した.The purpose of this paper is to report a case of minimal carcinoma of the thyroid manifested by a cystic metastasis to the cervical lymph nodes which mimicked a lateral cervical cyst in a 31-year-old male and to discuss the clinical significance of cystic metastasis from papillary adenocarcinoma of the thyroid