Mechanism of furosemide resistance in analbuminemic rats and hypoalbuminemic patients

Mechanism of furosemide resistance in analbuminemic rats and hypoalbuminemic patients. To elucidate the mechanism of resistance of hypoalbuminemic patients to furosemide, the effect of this diuretic on urine volume of normal and analbuminemic rats (NAR) and of hypoalbuminemic patients was studied. Intravenous administration of furosemide rapidly enhanced sodium diuresis in normal rats but not in NAR. Total plasma clearance and distribution volume of furosemide were much larger in NAR than in normal rats, while no significant difference in these pharmacokinetic parameters was observed for the unbound fraction of the diuretic between the two animal groups. In contrast, urinary secretion of furosemide was significantly lower in NAR than in normal rats. Injected furosemide bound to albumin markedly promoted diuresis in NAR, while the same dose of albumin alone had no effect, indicating that binding to albumin is essential for the delivery of furosemide to the kidney, the site for its action. Injection of the complex rapidly increased the urine volume of hypoalbuminemic patients who showed a marked resistance to this diuretic. Thus, the resistance to furosemide in both NAR and hypoalbuminemic patients may be explained on the same basis

Advanced Laser Diagnostics for Electron Density Measurements

This paper describes innovative laser diagnostics under development at the National Institute for Fusion Science, aiming for the establishment of reliable density measurement techniques in the next step magneticallyconfined fusion devices. There are two approaches, interferometry and polarimetry. A new type of two color laser (47.6/57.2-μm CH3OD) interferometer has been developed and its original function, vibration subtraction,was confirmed in a test stand. The line integrated density measurement at Compact Helical System by using the polarimeter based on Cotton-Mouton effect was demonstrated by the use of a 337-μm HCN laser source

Improvements of CO2 Laser Heterodyne Imaging Interferometer for Electron Density Profile Measurements on LHD

After installation of CO2 laser (wavelength 10.6 μm) heterodyne imaging interferometer (CO2 HI) in 2001, continuous developments have been carried out to improve the measurements capability and stability of operation. The CO2 HI works almost without phase jumping at high electron density (> 1 × 1020 m-3), where the existing far infrared laser (wavelength 118.9 μm) interferometer suffers from fringe jump due to the reduction of signal intensity caused by refraction. However a second interferometer is required to compensate mechanical vibration. A YAG laser (wavelength 1.06 μm) heterodyne imaging interferometer (YAG HI) is presently used for the vibration compensation. In the 10th LHD experimental campaign (2006?2007), sixty four channels of CO2 HI to measure electron density profile and ten channels of YAG HI to measure mechanical vibration are working. A measurement example of a pellet fuelled high-density discharge is reported

Effect of activated protein C on plasma plasminogen activator inhibitor activity in patients with acute myocardial infarction treated with alteplase Comparison with unfractionated heparin

AbstractObjectivesWe examined whether activated protein C (APC) is an effective conjunctive therapy to thrombolysis in patients with ST-segment–elevated acute myocardial infarction (AMl).BackgroundActivated protein C possesses both systemic anticoagulant and anti-inflammatory properties. It has been also shown to enhance fibrinolysis by inhibiting plasminogen activator inhibitor (PAI) activity in vitro.MethodsAfter successful thrombolysis with alteplase, study patients were assigned to receive one of the two conjunctive therapies for 48 h intravenously: human plasma-derived APC at 0.06 mg/kg per day (APC group, n = 9) or unfractionated heparin at 100 to 400 U/kg per day, adjusted to maintain an activated partial thromboplastin time at 1.5 to 2 times of the control level (heparin group, n = 10).ResultsAdverse events, including reocclusion of the recanalized infarct-related coronary artery and major or minor hemorrhagic complications, occurred more frequently in the heparin group (4 of 10 cases) than in the APC group (none of 9 cases) (p = 0.033). In the heparin group, plasma PAI activity (IU/ml, median value [range]) was increased continuously from 8 to 24 h after thrombolysis and peaked at 24 h (30.9 [11.3 to 38.5]); on the other hand, it was not increased in the APC group at 24 h after thrombolysis (11.3 [0.0 to 31.0], p < 0.01 vs. heparin group).ConclusionsAdministration of APC suppressed increasing of plasma PAI activity observed after thrombolysis in patients with AMI. The effect of APC could be more eligible, compared with heparin, as a conjunctive regimen to thrombolysis in AMI patients

Dynamic Quantizer Design Under Communication Rate Constraints

Feedback type dynamic quantizers such as delta-sigma modulators are typically effective for encoding high-resolution data into lower resolution data. The dynamic quantizers include a filter and a static quantizer. When it is required to control under a communication rate constraint, the data rate of the quantizer output should be minimized appropriately by quantization. This technical note provides numerical methods for the complete design of a type of dynamic quantizers, including the selection of all the quantizer parameters in order to minimize a specific performance index and satisfy a communication constraint. The design method of the dynamic quantizer is proposed using a particle swarm optimization (PSO) method. A part of the initial quantizers in PSO are designed based on an invariant set analysis and an iteration algorithm. Effectiveness of the system with the proposed quantizer is assessed through numerical examples