Inorganic Arsenite Potentiates Vasoconstriction through Calcium Sensitization in Vascular Smooth Muscle-4

<p><b>Copyright information:</b></p><p>Taken from "Inorganic Arsenite Potentiates Vasoconstriction through Calcium Sensitization in Vascular Smooth Muscle"</p><p>Environmental Health Perspectives 2005;113(10):1330-1335.</p><p>Published online 14 Jun 2005</p><p>PMCID:PMC1281275.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p

Inorganic Arsenite Potentiates Vasoconstriction through Calcium Sensitization in Vascular Smooth Muscle-1

<p><b>Copyright information:</b></p><p>Taken from "Inorganic Arsenite Potentiates Vasoconstriction through Calcium Sensitization in Vascular Smooth Muscle"</p><p>Environmental Health Perspectives 2005;113(10):1330-1335.</p><p>Published online 14 Jun 2005</p><p>PMCID:PMC1281275.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p

Inorganic Arsenite Potentiates Vasoconstriction through Calcium Sensitization in Vascular Smooth Muscle-2

<p><b>Copyright information:</b></p><p>Taken from "Inorganic Arsenite Potentiates Vasoconstriction through Calcium Sensitization in Vascular Smooth Muscle"</p><p>Environmental Health Perspectives 2005;113(10):1330-1335.</p><p>Published online 14 Jun 2005</p><p>PMCID:PMC1281275.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p

Inorganic Arsenite Potentiates Vasoconstriction through Calcium Sensitization in Vascular Smooth Muscle-0

<p><b>Copyright information:</b></p><p>Taken from "Inorganic Arsenite Potentiates Vasoconstriction through Calcium Sensitization in Vascular Smooth Muscle"</p><p>Environmental Health Perspectives 2005;113(10):1330-1335.</p><p>Published online 14 Jun 2005</p><p>PMCID:PMC1281275.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p

Cyclocurcumin, an Antivasoconstrictive Constituent of <i>Curcuma longa</i> (Turmeric)

Despite the increasing attention on the therapeutic potential of <i>Curcuma longa</i> (turmeric), the biological activities of curcuminoids other than curcumin are not well understood. Here, we investigated antivasoconstrictive activities of <i>C. longa</i> extract and its ingredients using freshly isolated rat aortic rings. <i>C. longa</i> extract significantly suppressed agonist-stimulated vasoconstriction, and cyclocurcumin was found to be the most potent (IC₅₀ against phenylephrine-induced vasoconstriction: 14.9 ± 1.0 μM) among the 10 tested ingredients including four curcuminoids. Cyclocurcumin significantly inhibited contraction of vascular smooth muscle, which was mediated by the suppression of myosin-light-chain phosphorylation and calcium influx via the L-type calcium channel. The inhibitory effect of cyclocurcumin was observed to be reversible and without cytotoxicity. Taken together, we demonstrated that cyclocurcumin, a bioactive ingredient in <i>C. longa</i>, may have a therapeutic potential as a novel antivasoconstrictive natural product