Suzaku Discovery of a Hard X-Ray Tail in the Persistent Spectra from the Magnetar 1E 1547.0-5408 during its 2009 Activity

The fastest-rotating magnetar 1E 1547.0-5408 was observed in broad-band X-rays with Suzaku for 33 ks on 2009 January 28-29, 7 days after the onset of its latest bursting activity. After removing burst events, the absorption-uncorrected 2-10 keV flux of the persistent emission was measured with the XIS as 5.7e-11 ergs cm-2 s-1, which is 1-2 orders of magnitude higher than was measured in 2006 and 2007 when the source was less active. The persistent emission was also detected significantly with the HXD in >10 keV up to at least ~110 keV, with an even higher flux of 1.3e-10 ergs cm-2 s-1 in 20-100 keV. The pulsation was detected at least up to 70 keV at a period of 2.072135+/-0.00005 s, with a deeper modulation than was measured in a fainter state. The phase-averaged 0.7-114 keV spectrum was reproduced by an absorbed blackbody emission with a temperature of 0.65+/-0.02 keV, plus a hard power-law with a photon index of ~1.5. At a distance of 9 kpc, the bolometric luminosity of the blackbody and the 2-100 keV luminosity of the hard power-law are estimated as (6.2+/-1.2)e+35 ergs s-1 and 1.9e+36 ergs s-1, respectively, while the blackbody radius becomes ~5 km. Although the source had not been detected significantly in hard X-rays during the past fainter states, a comparison of the present and past spectra in energies below 10 keV suggests that the hard component is more enhanced than the soft X-ray component during the persistent activity.Comment: 12 pages, 7 figures, PASJ Vol.62 No.2 accepte

Use of FDG-PET in Radiation Treatment Planning for Thoracic Cancers

Radiotherapy plays an important role in the treatment for thoracic cancers. Accurate diagnosis is essential to correctly perform curative radiotherapy. Tumor delineation is also important to prevent geographic misses in radiotherapy planning. Currently, planning is based on computed tomography (CT) imaging when radiation oncologists manually contour the tumor, and this practice often induces interobserver variability. F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) has been reported to enable accurate staging and detect tumor extension in several thoracic cancers, such as lung cancer and esophageal cancer. FDG-PET imaging has many potential advantages in radiotherapy planning for these cancers, because it can add biological information to conventional anatomical images and decrease the inter-observer variability. FDG-PET improves radiotherapy volume and enables dose escalation without causing severe side effects, especially in lung cancer patients. The main advantage of FDG-PET for esophageal cancer patients is the detection of unrecognized lymph node or distal metastases. However, automatic delineation by FDG-PET is still controversial in these tumors, despite the initial expectations. We will review the role of FDG-PET in radiotherapy for thoracic cancers, including lung cancer and esophageal cancer

Clinical Analysis of 110 Postoperative Deaths of the Patients with Permanent Implantable Pacemaker

During 14 years follow up of 754 patients received permanent cardiac pacemaker (PM) implantation, 110 cases have died. In this paper, the cause of death of them was clinically analyzed. The death to senility was most frequent, in 31 cases out of 110 deaths (28.2%), and then heart failure in 19 cases (17.3%), cerebrovascular disease in 16 cases (14.5%), sudden death in 14 cases (12.7%), malignancy in 7 cases (6.4%), acute myocardial infarction in 7 cases (6.4%), severe infectious disease in 4 cases (3.6%), unknown etiology in 4 cases (3.6%), renal failure and Disseminated Intravascular Coagulation Syndrome (DIC) in 2 cases (1.8%), respectively, suicide in one case (0.9%). Cause of death by underlying disease was rather characteristic. Senility was frequent in the patients with atrioventricular (A-V) block (38.5%), while cerebrovascular disease was highly observed in the patients with Sick Sinus Syndrome (SSS) (28.1%), and heart failure was highly observed in the patients with atrial fibrillation (46.2%). Senility was seen in 44.8% of the patients with coronary arteriosclerosis, cardiac death in 85. 7% of the patients with cardiomyopathy, and in 100.0% of the cases with valvular disease. The above mentioned fact suggests that cardiovascular check up is most important in postoperative follow up of the patients with PM. In old cases, senility and infection were major cause of death, so guidance concerning to dietary life and periodical health examination against wasting disease is important especially in this group. And, active care for heart failure is also more important in the patients with cardiomyopathy and valvular disease

Ionic Conductivities of Molten CuI and AgI-CuI Mixtures

Ionic conductivities σ for molten CuI and AgI-CuI mixtures were measured in the temperature ranges of approximately 580-800 and 500-850 °C, respectively. The value of σ for molten CuI in the range is smaller than that for molten CuBr and CuCl. σ for molten AgI-CuI mixtures decreases with increasing CuI-concentration. The activation energies Ea for molten AgI-CuI system were determined from the analysis of temperature dependence of σ by using the by Arrhenius type equation. Ea for molten AgI-CuI gradually increase with increasing CuIconcentration

Determination of 1-nitropyrene in low volume ambient air samples by high-performance liquid chromatography with fluorescence detection

金沢大学医薬保健研究域薬学系To measure the actual exposure of a person to 1-nitropyrene (1-NP) in airborne particulate matter, it is considered more accurate to collect air samples with a portable air sampler than to sample at a fixed location. However, because the portable samplers can sample only small volumes, a sensitive method is needed to analyze the compounds that are collected on a filter. Here we describe a high-performance liquid chromatographic (HPLC) method with fluorescence detection that is sensitive and precise enough for use with portable air samplers. The developed column-switching system successfully removed the interfering substances in the samples with only a simple pretreatment. To improve the precision of the measurement, deuterated 1-NP was used as an internal standard, and it eluted immediately prior to 1-NP with sufficient resolution (Rs, 1.50). The detection limit was 0.32 fmol/injection, and the calibration range was from 2 to 100 fmol. The proposed method was applied to determining 1-NP in fine airborne particulate matter (PM2.5) at two sites with low pollution levels. 1-NP was detected in all samples at concentrations in the low fmol/m3 range. The proposed method has enough sensitivity and precision to determine 1-NP in the limited air volume of the portable sampler. © 2009 Elsevier B.V. All rights reserved

In Vitro Assessment of Factors Affecting the Apparent Diffusion Coefficient of Ramos Cells Using Bio-phantoms

The roles of cell density, extracellular space, intracellular factors, and apoptosis induced by the molecularly targeted drug rituximab on the apparent diffusion coefficient (ADC) values were investigated using bio-phantoms. In these bio-phantoms, Ramos cells (a human Burkittｾs lymphoma cell line) were encapsulated in gellan gum. The ADC values decreased linearly with the increase in cell density, and declined steeply when the extracellular space became less than 4 μm. The analysis of ADC values after destruction of the cellular membrane by sonication indicated that approximately 65% of the ADC values of normal cells originate from the cell structures made of membranes and that the remaining 35% originate from intracellular components. Microparticles, defined as particles smaller than the normal cells, increased in number after rituximab treatments, migrated to the extracellular space and significantly decreased the ADC values of bio-phantoms during apoptosis. An in vitro study using bio-phantoms was conducted to quantitatively clarify the roles of cellular factors and of extracellular space in determining the ADC values yielded by tumor cells and the mechanism by which apoptosis changes those values

StreamDiffusion: A Pipeline-level Solution for Real-time Interactive Generation

We introduce StreamDiffusion, a real-time diffusion pipeline designed for interactive image generation. Existing diffusion models are adept at creating images from text or image prompts, yet they often fall short in real-time interaction. This limitation becomes particularly evident in scenarios involving continuous input, such as Metaverse, live video streaming, and broadcasting, where high throughput is imperative. To address this, we present a novel approach that transforms the original sequential denoising into the batching denoising process. Stream Batch eliminates the conventional wait-and-interact approach and enables fluid and high throughput streams. To handle the frequency disparity between data input and model throughput, we design a novel input-output queue for parallelizing the streaming process. Moreover, the existing diffusion pipeline uses classifier-free guidance(CFG), which requires additional U-Net computation. To mitigate the redundant computations, we propose a novel residual classifier-free guidance (RCFG) algorithm that reduces the number of negative conditional denoising steps to only one or even zero. Besides, we introduce a stochastic similarity filter(SSF) to optimize power consumption. Our Stream Batch achieves around 1.5x speedup compared to the sequential denoising method at different denoising levels. The proposed RCFG leads to speeds up to 2.05x higher than the conventional CFG. Combining the proposed strategies and existing mature acceleration tools makes the image-to-image generation achieve up-to 91.07fps on one RTX4090, improving the throughputs of AutoPipline developed by Diffusers over 59.56x. Furthermore, our proposed StreamDiffusion also significantly reduces the energy consumption by 2.39x on one RTX3060 and 1.99x on one RTX4090, respectively.Comment: tech report, the code is available at https://github.com/cumulo-autumn/StreamDiffusio

PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens

ΔFosB is a stable transcription factor which accumulates in the nucleus accumbens (NAc), a key part of the brain’s reward circuitry, in response to chronic exposure to cocaine or other drugs of abuse. While ΔFosB is known to heterodimerize with a Jun family member to form an active transcription factor complex, there has not to date been an open-ended exploration of other possible binding partners for ΔFosB in the brain. Here, by use of yeast two-hybrid assays, we identify PSMC5—also known as SUG1, an ATPase-containing subunit of the 19S proteasomal complex—as a novel interacting protein with ΔFosB. We verify such interactions between endogenous ΔFosB and PSMC5 in the NAc and demonstrate that both proteins also form complexes with other chromatin regulatory proteins associated with gene activation. We go on to show that chronic cocaine increases nuclear, but not cytoplasmic, levels of PSMC5 in the NAc and that overexpression of PSMC5 in this brain region promotes the locomotor responses to cocaine. Together, these findings describe a novel mechanism that contributes to the actions of ΔFosB and, for the first time, implicates PSMC5 in cocaine-induced molecular and behavioral plasticity.National Institutes of Health (U.S.)National Institute on Drug AbuseIshibashi FoundationJapan Society for the Promotion of Science (KAKENHI 24591735)Japan Society for the Promotion of Science (KAKENHI 26290064)Japan Society for the Promotion of Science (KAKENHI 25116010

Tuberous Sclerosis 2 Gene Is Expressed at High Levels in Specific Types of Neurons in the Mouse Brain

Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by mental retardation, epilepsy and hamartomatous growth in many tissues. The gene (TSC2) encoding a tumor suppressor protein whose mutations cause TSC, has been demonstrated to be expressed at high levels in the adult and developing brain, raising the question of whether or not the TSC2 gene product has unique roles in differentiation related to cytoskeletal interactions within the central nervous system, in addition to a tumor suppressor function. To determine the expression of TSC2 in functionally distinct neuron types of the mouse brain, we carried out in situ hybridization with digoxigenin-labeled riboprobes for the detection of TSC2 mRNA. High levels of the TSC2 gene were in neurons of the pyramidal and dentate granular layer in the hippocampus, cerebellar Purkinje cells, neurons of the piriform cortex, motor neurons in the medulla and interneurons in the striatum, while intermediate levels were in cortical neurons, striatal neurons, septal neurons, thalamic neurons and neurons in the substantia nigra compacta. Thus, the high expression of the TSC2 gene has restricted distribution in specific neuronal types which are characterized by well-developed dendrites and rich in use-dependent long-term changes in synaptic efficacy. These results suggest that the function of the TSC2 gene product may be involved on a cellular basis in neuronal plasticity and relevant to mental retardation observed in TSC patients