84 research outputs found
The pH of the skin surface and its impact on the barrier function
The `acid mantle' of the stratum corneum seems to be important for both permeability barrier formation and cutaneous antimicrobial defense. However, the origin of the acidic pH, measurable on the skin surface, remains conjectural. Passive and active influencing factors have been proposed, e. g. eccrine and sebaceous secretions as well as proton pumps. In recent years, numerous investigations have been published focusing on the changes in the pH of the deeper layers of the stratum corneum, as well as on the influence of physiological and pathological factors. The pH of the skin follows a sharp gradient across the stratum corneum, which is suspected to be important in controlling enzymatic activities and skin renewal. The skin pH is affected by a great number of endogenous factors, e. g. skin moisture, sweat, sebum, anatomic site, genetic predisposition and age. In addition, exogenous factors like detergents, application of cosmetic products, occlusive dressings as well as topical antibiotics may influence the skin pH. Changes in the pH are reported to play a role in the pathogenesis of skin diseases like irritant contact dermatitis, atopic dermatitis, ichthyosis, acne vulgaris and Candida albicans infections. Therefore, the use of skin cleansing agents, especially synthetic detergents with a pH of about 5.5, may be of relevance in the prevention and treatment of those skin diseases. Copyright (c) 2006 S. Karger AG, Base
Mapping Protein Interactions between Dengue Virus and Its Human and Insect Hosts
Dengue virus (DENV) represents a major disease burden in tropical and subtropical regions of the world, and has shown an increase in the number of cases in recent years. DENV is transmitted to humans through the bite of an infected mosquito, typically Aedes aegypti, after which it begins the infection and replication lifecycle within human cells. To perform the molecular functions required for invasion, replication, and spread of the virus, proteins encoded by DENV must interact with and alter the behavior of protein networks in both of these hosts. In this work, we used a computational method based on protein structures to predict interactions between DENV and its human and insect hosts. We predict numerous interactions, with many involved in known cell death, stress, and immune system pathways. Further investigation of these predicted protein-protein interactions should provide targets to combat the clinical manifestations of this disease in humans as well as points of intervention focused within the mosquito vector
Higgs Physics at LEP2
In this report we review the prospects for Higgs physics at LEP2. The
theoretical aspects and the phenomenology of Higgs particles are discussed
within the Standard Model (SM) and the Minimal Supersymmetric Standard Model
(MSSM). The experimental search techniques are described and the discovery
limits for Higgs bosons in the LEP2 energy range are summarized. In addition,
opportunities of detecting Higgs particles in non-minimal extensions of the SM
and the MSSM are investigated.Comment: 112 pages, latex file + figures (some bitmapped), to appear in Vol.
1, Report of the Workshop on Physics at LEP2, G. Altarelli, T. Sjostrand and
F.Zwirner (eds), CERN 96-01. (Full postscript and uuencoded files, including
full resolution figures are available at the www address
http://surya11.cern.ch/surya_info/users/mcarena in finrep.ps, finrep.uu
Biomedical informatics and translational medicine
Biomedical informatics involves a core set of methodologies that can provide a foundation for crossing the "translational barriers" associated with translational medicine. To this end, the fundamental aspects of biomedical informatics (e.g., bioinformatics, imaging informatics, clinical informatics, and public health informatics) may be essential in helping improve the ability to bring basic research findings to the bedside, evaluate the efficacy of interventions across communities, and enable the assessment of the eventual impact of translational medicine innovations on health policies. Here, a brief description is provided for a selection of key biomedical informatics topics (Decision Support, Natural Language Processing, Standards, Information Retrieval, and Electronic Health Records) and their relevance to translational medicine. Based on contributions and advancements in each of these topic areas, the article proposes that biomedical informatics practitioners ("biomedical informaticians") can be essential members of translational medicine teams
Cost Effectiveness of a Pharmacist-Led Information Technology Intervention for Reducing Rates of Clinically Important Errors in Medicines Management in General Practices (PINCER)
EFFECTS OF BLUE-LIGHT ON PYRUVATE KINASE ACTIVITY DURING CHLOROPLAST DEVELOPMENT OF UNICELLULAR GREEN ALGAE*
Studiensoftware in den Koordinierungszentren für Klinische Studien (KKS): Status und Empfehlungen für den Einsatz von Electronic Data Capture
Resistance to cattle tick (Rhipicephalus microplus) infestation: immunological or physiological?
Oral presentatio
Cytokine regulation of the intracellular growth of Mycobacterium paratuberculosis in bovine monocytes
Реэистентные свойства гатерслебенской коллекции ячменя и пшеницы. 25. Проверка реакции ячменей на их восприимчивость к вирусу жëлтой мозаики (barley yellow mosaic virus)
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