RelatiOnship between the impact of invasive largemouth bass and environmental conditions in ponds

detemine the relationship between the impact of introdllCed largemouth bass on native -fish fauna and the environmental conditions in ponds, we compared richness and diversityof fish species, environmental factors and the relationship betweenthem in ponds with and without bass. The stlldy was conducted at 49 Ponds in Oshu city in lwate prefecture, northeastern Japan･ For determiningthe impact of largemouth bass on fish fauna in ponds, Pearson's correlation wasused between the dominance of largemouth bass (%BASS), total number (S) and diversity index (H') of occurring fish species. Furthermore, multiple regression analysis was used to detemine the relationship between S or HT and environmental factors･ %BASS was negatively correlated with both S and H'. In ponds without bass, both S and H'were`related to maximum depth and S in ponds with bass was also related to maximum depth. However, I-r in ponds withbass was significantly influenced by the coverage of emergent plants and was more clearly explained compared to the relationship between S and maximum depth･ It suggested it is possible that emergent plants also provide refuge for prey fish, buffering the impact of largemouth bass･Article信州大学山地水環境教育研究センター研究報告 6: 133-141(2010)departmental bulletin pape

Successful Endoscopic Closure Using Polyglycolic Acid Sheets with Fibrin Glue for Nonhealing Duodenal Ulcer with Perforation after Proton Beam Therapy of Liver Tumor

We describe the first case of a nonhealing duodenal ulcer with perforation after proton beam therapy (PBT) of a liver tumor that was successfully treated endoscopically using polyglycolic acid (PGA) sheets with fibrin glue. A 69-year-old man received PBT for a liver tumor. Esophagogastroduodenoscopy (EGD) 3 months after PBT revealed a duodenal ulcer. A proton pump inhibitor was administered for 7 weeks, and the ulcer healed. Six months after the EGD, recurrence of the duodenal ulcer with perforation occurred. An emergency open surgery with placement of the omental patch was performed. However, 5 days after the surgery, because the EGD revealed a perforation site in the duodenal ulcer that was not closed, the conservative treatment was continued. Twenty-eight days after the surgery, EGD revealed that the perforation size had increased. Therefore, we conducted endoscopic closure therapy using PGA sheets with fibrin glue. Eleven days after the closure procedure, the EGD showed that the perforation site was filled with granulation tissue and was closed. Forty-nine days after the procedure, EGD revealed that the ulcer had healed. This endoscopic closure treatment was effective for a nonhealing duodenal ulcer with perforation after PBT of a liver tumor

Es velozmente fugaz todo lo celestial

Fiesta de la paz (traducción y prólogo de Rafael Gutiérrez Girardot). Friedrich Holderlin. El Ancora Editores, Santafé de Bogotá, 1994, 85 págs

Drug treatment for chemotherapy-induced peripheral neuropathy in patients with pancreatic cancer

Pancreatic cancer (PC) is a lethal disease where most tumors are too advanced at diagnosis for resection, leaving chemotherapy as the mainstay of treatment. Although the prognosis of unresectable PC is poor, it has been dramatically improved by new chemotherapy treatments, such as the combination of 5-fluorouracil, oxaliplatin, irinotecan, and leucovorin (FOLFIRINOX) or gemcitabine plus nab-paclitaxel. However, as oxaliplatin and paclitaxel are common neurotoxic drugs, chemotherapy-induced peripheral neuropathy (CIPN) is a common and severe adverse effect of both treatments. As there are no agents recommended in the ASCO guidelines, we review the methods used to treat CIPN caused by PC treatment. The efficacy of duloxetine was observed in a large randomized controlled trial (RCT). In addition, pregabalin was more effective than duloxetine for CIPN in two RCTs. Although duloxetine and pregabalin can be effective for CIPN, they have several side effects. Therefore, the choice between the two drugs should be determined according to effect and tolerability. Mirogabalin is also used in patients with PC and there is hope it will yield positive outcomes when treating CIPN in the future

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Comparison of food habits between native Amur three-lips (

The Amur three-lips (Opsariichthys uncirostris uncirostris) is an endemic subspecies in Japan and native to the river systems of the Lake Biwa–Yodo River. The population of three-lips in Lake Biwa has decreased, primarily due to habitat degradation and introduction by competitive, non-native predators, such as largemouth bass (Micropterus salmoides). However, the effects of bass introduction on the three-lips are unclear. We investigated the food habits of the three-lips and compared them with those of sympatric non-native largemouth bass in Lake Biwa. A total of 145 three-lips and 178 largemouth bass were sampled during the summer and fall of 2013. Fish prey, particularly ayu (Plecoglossus altivelis altivelis), was predominant in the three-lips diet, followed by terrestrial insects. Decapods (i.e., prawn and shrimp), ayu and demersal fish (e.g., gobids) composed a substantial proportion of bass diets. No significant dietary overlaps were found between the two predators. Our results suggest that differences in food habits between the two species may result from differences in feeding behavior; the three-lips is a mobile predator that forages mainly on nektonic and suspended food, whereas largemouth bass is an ambush predator that forages on both nektonic and benthic prey. We referred the results of three-lips diets in Lake Biwa in a previous study and suggest that changes in fish fauna, due to introduction by non-native largemouth bass, may have affected prey availability for the three-lips.Food habits of native Amur three-lips (Opsariichthys uncirostris uncirostris) were significantly different from non-native largemouth bass (Micropterus salmoides) in Lake Biwa, Japan. However, changes in fish fauna of the Lake, due to predatory impacts by non-native bass, may have affected preferable prey availability for the three-lips