Characteristics and Blood Pressure Profile of Goitre Patients in A Tertiary Hospital in South-West Nigeria

Background: Goitre remains endemic in iodine deficient areas of the world despite widespread introduction of iodine fortified food. In Nigeria, it is the second most common condition in endocrinology clinic. There is a therefore a need to document the blood pressure profile and clinical characteristics of this condition.Objective: This study assessed the clinical characteristics, biochemical and blood pressure profile of patients with goitre in the study area and assessed their knowledge and practice of preventive measures against goitre.Methodology: A comparative study of 103 adults with goitres and 103 healthy controls. An interviewer administered questionnaire was used and venous blood samples were obtained for analyses. Variables of interest included socio-demographic, anthropometric, thyroid function, and blood pressure.Results: The mean age of the goitre group was 46.92 ± 13.85 years with 86.4% carrying the swelling for up to 5 years. Anthropometric parameters, social habits, knowledge, and practice of the preventive role of iodized salt were similar between the goitre and control  groups. Forty-six percent of the goitrous subjects were hyperthyroid. Weight and BMI were significantly higher among the hypothyroid subgroup (p<0.001), with subjects in the hyperthyroid subgroup having significantly higher pulse rate and systolic blood pressure  (p<0.001). The hypothyroid subgroup had significantly higher diastolic blood pressure and lower pulse pressure (p< 0.001).Conclusion: This study concluded that patients with hyperthyroidism and hypothyroidism were more likely to have elevated systolic and diastolic blood pressure, respectively. Routine cardiovascular status check is therefore important in goitrous patients

Assessment of functional capacity and sleep quality of patients with chronic heart failure

Background: Adequate sleep improves physical and mental alertness. However, there is a dearth of empirical data on functional capacity (FC) and sleep quality (SpQ) in patients with chronic heart failure (CHF). Objective: This study investigated the relationship between FC and SpQ of patients with CHF and apparently healthy controls (HCs). Methods: This case-control study recruited 50 patients with CHF whose left ventricular ejection fraction (LVEF) was <40%, attending cardiac clinics of selected government hospitals in Osun State. Furthermore, 50 age- and sex-matched healthy individuals were recruited as controls. Socio-demographic characteristics and cardiovascular parameters were assessed. The FC (VO2 max) and SpQ were assessed using the 6-minute walk test (6-MWT) and Pittsburgh Sleep Quality Index (PSQI), respectively. Data were analysed using descriptive and inferential statistics. Alpha level was set at p < 0.05. Results: Patients had a significantly lower FC and poorer SpQ than HCs, 4.6 ± 0.5 versus 11.3 ± 1.6 mL/kg/min (t = −3.452; p = 0.001) and 8.74 ± 1.6 versus 3.8 ± 1.3 (t = −5.371; p = 0.001), respectively. HCs were about five times more likely to walk longer distance [odds ratio (OR), 4.8; confidence interval (CI), 2.0–11.1] and had a better heart rate (OR, 2.8; CI, 1.4–5.3) than patients. SpQ had a significant negative correlation with FC of patients (r = −0.362; p = 0.001) but a significant positive correlation with HCs (r = 0.481; p = 0.041). Furthermore, there were significant correlations between FC and body mass index in both groups (CHF: r = 0.247, p = 0.022; HCs: r = 0.321, p = 0.040). Conclusion: Patients with heart failure demonstrated lower functional capacity and poorer sleep quality