秋の北極海と冬のオホーツク海に於ける海氷の十年規模共変動

日本気象学会2012年度秋季大会（2012年12月3日～5日, 北海道大学 学術交流会館） / 発表番号: P17

北半球冬季の大気大循環と日本周辺の海面水温が日本の気温に与える影響

第6回極域科学シンポジウム分野横断セッション：[IA] 急変する北極気候システム及びその全球的な影響の総合的解明―GRENE北極気候変動研究事業研究成果報告2015―11月19日（木）　国立極地研究所１階交流アトリウ

Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair

UV-sensitive syndrome (UVSS) is a genodermatosis characterized by cutaneous photosensitivity without skin carcinoma1, 2, 3, 4. Despite mild clinical features, cells from individuals with UVSS, like Cockayne syndrome cells, are very UV sensitive and are deficient in transcription-coupled nucleotide-excision repair (TC-NER)2, 4, 5, which removes DNA damage in actively transcribed genes6. Three of the seven known UVSS cases carry mutations in the Cockayne syndrome genes ERCC8 or ERCC6 (also known as CSA and CSB, respectively)7, 8. The remaining four individuals with UVSS, one of whom is described for the first time here, formed a separate UVSS-A complementation group1, 9, 10; however, the responsible gene was unknown. Using exome sequencing11, we determine that mutations in the UVSSA gene (formerly known as KIAA1530) cause UVSS-A. The UVSSA protein interacts with TC-NER machinery and stabilizes the ERCC6 complex; it also facilitates ubiquitination of RNA polymerase IIo stalled at DNA damage sites. Our findings provide mechanistic insights into the processing of stalled RNA polymerase and explain the different clinical features across these TC-NER–deficient disorders

Trends in the Summer Northern Annular Mode and Arctic Sea Ice

The summer Arctic sea ice extent (SIE) during the period 1996-2008 had an accelerating trend of retreat. The difference of SIE between May and September has a significant correlation with the summer Northern Hemisphere Annular Mode (summer NAM). The summer NAM had a significant positive trend during the period 1958-1996, and a weak negative trend during the period 1996-2008. The atmospheric circulation during the recent period had a trend of anticyclonic circulation over the Arctic with easterly wind over the marginal seas. In addition, tropospheric warming was enhanced especially over the Arctic and near the ground surface

Trends in the Summer Northern Annular Mode and Arctic Sea Ice

The summer Arctic sea ice extent (SIE) during the period 1996−2008 had an accelerating trend of retreat. The difference of SIE between May and September has a significant correlation with the summer Northern Hemisphere Annular Mode (summer NAM). The summer NAM had a significant positive trend during the period 1958−1996, and a weak negative trend during the period 1996−2008. The atmospheric circulation during the recent period had a trend of anticyclonic circulation over the Arctic with easterly wind over the marginal seas. In addition, tropospheric warming was enhanced especially over the Arctic and near the ground surface. 1