The Blister Score: A Novel, Externally Validated Tool for Predicting Cardiac Implantable Electronic Device Infections, and Its Cost-utility Implications for Antimicrobial Envelope Use.

Background: Antimicrobial envelopes reduce the incidence of cardiac implantable electronic device (CIED) infections, but their cost restricts routine use in the UK. Risk scoring could help identify which patients would most benefit from this technology. Methods: A novel risk score (BLISTER) was derived from multivariate analysis of factors associated with CIED infection. Diagnostic utility was assessed against the existing PADIT score in both standard and high-risk external validation cohorts, and cost-utility models examined different BLISTER and PADIT score thresholds for TYRXTM antimicrobial envelope (AE) allocation. Results: In a derivation cohort (n=7,383), CIED infection occurred in 59 individuals within 12 months of a procedure (event rate: 0.8%). In addition to the PADIT score constituents, lead extraction (HR 3.3 (1.9-6.1), p50mg/l (HR 3.0 (1.4-6.4), p=0.005), re-intervention within two years (HR 10.1 (5.6-17.9), p<0.0001), and top-quartile procedure duration (HR 2.6 (1.6-4.1), p=0.001) were independent predictors of infection. The BLISTER score demonstrated superior discriminative performance versus PADIT in the standard-risk (n=2,854, event rate: 0.8%, AUC 0.82 vs 0.71, p=0.001) and high-risk validation cohorts (n=1,961, event rate: 2.0%, AUC 0.77 vs 0.69, p=0.001), and in all patients (n=12,198, event rate: 1%, AUC 0.8 vs 0.75, p=0.002). In decision-analytic modelling, the optimum scenario assigned AEs to patients with BLISTER scores ≥ 6 (10.8%), delivering a significant reduction in infections (relative risk reduction: 30%, p=0.036) within the NICE cost-utility thresholds (ICER: ￡18,446). Conclusions: The BLISTER score (https://qxmd.com/calculate/calculator_876/the-blister-score-for-cied-infection) was a valid predictor of CIED infection, and could facilitate cost-effective AE allocation to high-risk patients

Effects of Organic And Inorganic Manures on The Yield Of Yam Tubers In Termite Infested Soils

A study on the effects of different organic and inorganic manures on the yield of yam tubers in termite infested soil of Owerri Imo State, South Eastern Nigeria was carried out at the Teaching and Research Farm of the Federal University of Technology, Owerri in 2004 and 2005 cropping seasons respectively. The soil was naturally infested with three types of termite genera, namely: Microtermes, Ancistrotermes and Macrotermes. The variety of yam used was Dioscorea rotundata (white yam) cultivar (cv.) Obioaturugo, planted in May 2004 and 2005 respectively. The experiments were laid out in a randomized complete block design (RCBD) with three replications. The treatments were poultry manure at 1.5 tons ha-1 (PMI) and at 3.0 tons ha -1 (PM2), pig slurry at 1.5 tons ha-1 (PS1) and at 3.0 tons ha-1 (PS2), municipal waste at 1.5 tons ha-1 (MW1) and at 3.0 tons ha-1 (MW2), NPK 15:15:15, NPKMg 12:12:17:2, NPK 20:10:10 each at 400kgha-1 and control (no manuring). Result showed that highest fresh tuber yield was recorded in plots where NPK 15:15:15 and NPK Mg 12:12:17:12 were applied in both years while the least was in control plots. Also in both years of the experiment, plots treated with organic manures generally gave lower fresh tuber yield than inorganic but showed marked reduction in termite damage especially with municipal wastes when compared with other treatments. Similarly, plots treated with organic manures gave higher soil pH after tuber harvest than inorganic manures. Keywords: inorganic manure, organic manure, termites, and tuber yield. International Journal of Agriculture and Development Vol. 9 2007: pp. 66-7

Field Evaluation of Various Plant Biocides in the Control of Black Sigatoka Disease in Plantians

A field experiment was conducted at the Federal University of Technology, Teaching and Research Farm, Owerri in 2005 to evaluate the efficiency of using seven plant biocides (extracts) in the control of Black Sigatola disease in plantains. The experiment was carried out using the randomized complete block design with three replications. The Treatments include: Azadiractha indica (neem plant), Vernonia amygdlina (Bitter leaf) Ocimum gratissium (Nchanwu) Pergularia sp (utazi) Allium sativum (garlic), Citrus aurantifolia (lime) and Piper guinensis. (African Black Pepper). Data on disease development and efficacy of each plant biocide were collected at flowering on 5 plants of maturity per plot using the youngest leaf spotted (YLS) method. The proportion of the leaf area showing symptoms was scored on a scale of 0 to 6. A disease severity index (DSI) which also had a low DSI was also calculated were analyzed using the analysis of variance. Pair-wise testing between means was done using the Duncan New multiple range test at 5% level of probability. Results indicated that the ethanol extracts of plant biocides from Azadiractha indica and Piper guinensis were significantly (P. = 0.05) more effective than other plant biocides as observed from the youngest leaf spotted (YLS) assessed at flowering after 8 spray applications. The DSI recorded two weeks before harvest has 1.6 for Azadiractha indica and 0.8 for Piper guinensis which confirmed results from the YLS assessment. It is hereby strongly recommended to apply ethanol extract sprays of Azadiractha indica and Piper guinensis extracted at the rate of 20g plant material dissolved in 100ml ethanol due to its high level of fungitoxic ability on Black Sigatoka disease in plantains. It was also observed that ethanol extract of plant materials was more effective and efficacious in fungitoxic ability than the water extracts respectively