Perturbations of Spacetime around a Stationary Rotating Cosmic String

We consider the metric perturbations around a stationary rotating Nambu-Goto string in Minkowski spacetime. By solving the linearized Einstein equations, we study the effects of azimuthal frame-dragging around the rotation axis and linear frame-dragging along the rotation axis, the Newtonian logarithmic potential, and the angular deficit around the string as the potential mode. We also investigate gravitational waves propagating off the string and propagating along the string, and show that the stationary rotating string emits gravitational waves toward the directions specified by discrete angles from the rotation axis. Waveforms, polarizations, and amplitudes which depend on the direction are shown explicitly.Comment: 30 pages, 6 figures; Minor corrections, references added, published version in Physical Review

Brain tumors induced in rats by human adenovirus type 12

Oncogenesis of human adenovirus type 12 in the brain of rats was examined. Newborn rats of Sprague-Dawley and Donryu&#12288;strains were injected intracranially with human adenovirus type 12.&#12288;The incidence of intracranial tumors was 91% (30/33) in SpragueDawley&#12288;and 56% (14/25) in Donryu rats. Except for one tumor nodule&#12288;located in the parietal cortex of a Sprague.Dawley rat, all tumors&#12288;developed in the paraventricular areas or in the meninges. Tumors were quite similar histologically to those induced in hamsters and&#12288;mice resembling the undifferentiated human brain tumors such as medulloblastoma,&#12288;ependymoblastoma and embryonic gliomas. From&#12288;the histological features and primary sites of tumor development, it is&#12288;suggested that the tumors in the brain of rats induced by adenovirus type 12 originate from the embryonic cells in the&#12288;paraventricular area&#12288;and also from the undifferentiated supporting cells of the peripheral&#12288;nerves in the&#12288;leptomeninges.</p

Multiple Chemical Sensitivities Following Intolerance to Azo Dye in Sweets in a 5-year-old Girl

ABSTRACTBackgroundCases of multiple chemical sensitivities (MCS) have been reported predominantly in adult patients, but pediatric cases have rarely been reported.MethodsWe present a 5-year-old girl who suffered from recurrent reactions accompanied by urticaria, angioedema, headaches, dyspnea, loss of consciousness, and abdominal pain that were not eradicated, but were instead exacerbated, by various treatments with antihistamines and intravenous corticosteroids. Her diet diary revealed that symptoms occurred after ingestion of colorful sweets such as candies and jellybeans. Open challenge tests with food additives and nonsteroidal anti-inflammatory drugs (NSAIDs) were performed after elimination of these items. Skin prick tests using additives and NSAIDs, which were dissolved in saline, and prick-prick tests using candies and jellybeans, were carried out.ResultsOpen challenge tests with Tartrazine, aspirin and acetaminophen were positive, whereas skin prick tests using additives and NSAIDs and prick-prick tests using candies and jellybeans were all negative. Consequently, intolerance to azo dyes and NSAIDs such as aspirin was diagnosed. However, she appeared to react to multiple chemical odors such as those of cigarette smoke, disinfectant, detergent, cleaning compounds, perfume, and hairdressing, all while avoiding additives and NSAIDs. On the basis of her history and the neuro-ophthalmological abnormalities, a diagnosis of severe MCS was made and she was prescribed multiple vitamins and glutathione.ConclusionsThe present results suggest that in pediatric MCS, food and drug additives containing azo dyes might play important roles as elicitors

Advanced RO element obtained by new membrane and channel material

Introduction Reverse osmosis (RO) membranes are regarded as the most powerful tools to solve global water problems, since they make it possible to supply high-grade water with low cost and low energy consumption. RO membrane technologies have made great progress in last 50 years. However, still more improvement of membrane performance is required to achieve lower energy consumption and higher water quality in seawater, brackish water, and tap water desalination field. Toray has made efforts to elucidate dynamics of water molecules during water permeation process using neutron scattering and molecular dynamics simulation. Utilizing these results, new RO membranes with high water permeability was developed based on advanced molecular design of cross-linked polyamide pore structure. In addition, Toray created a new permeate channel material of element with low water flow resistance that enhanced water flux of the new RO membrane element. Material and Method Polyamide RO membranes were fabricated by interfacial polymerization of aromatic amines and carboxylic acid chlorides. Protuberance and pore structures of the polyamide RO membranes were analyzed by Transmission Electron Microscope (TEM) and molecular dynamics (MD) simulation. (Figure 1) Please click Additional Files below to see the full abstract

Genome-Wide Association Study of Coronary Artery Disease

Coronary artery disease (CAD) is a multifactorial disease with environmental and genetic determinants. The genetic determinants of CAD have previously been explored by the candidate gene approach. Recently, the data from the International HapMap Project and the development of dense genotyping chips have enabled us to perform genome-wide association studies (GWAS) on a large number of subjects without bias towards any particular candidate genes. In 2007, three chip-based GWAS simultaneously revealed the significant association between common variants on chromosome 9p21 and CAD. This association was replicated among other ethnic groups and also in a meta-analysis. Further investigations have detected several other candidate loci associated with CAD. The chip-based GWAS approach has identified novel and unbiased genetic determinants of CAD and these insights provide the important direction to better understand the pathogenesis of CAD and to develop new and improved preventive measures and treatments for CAD