Clindamycina în tratamentul prostatitei uretrogene (rezultate preliminare)

Summary. The study was performed on the basis of the data accumulated while applying antibacterial treatment for 53 patients with sexual transmitted disease. The results showed the increased efficiency of clindamycine in treatment of chronic uretrogenic prostatitis associated with Chi. Trachomatis si Ur. Urealythicum (Мус. Hominis)

The role of oophorectomy as adjuvant complex therapy for patients with breast cancer (preliminary assessment)

Catedra de oncologie, hematologie și radioterapie, USMF „Nicolae Testemițanu”, Institutul Oncologic, Chișinău, Republica Moldova, Conferința stiințifică „Nicolae Anestiadi – nume etern al chirurgiei basarabene” consacrată centenarului de la nașterea profesorului Nicolae Anestiadi 26 august 2016Introducere. Cea mai eficientă metodă de stopare a producerii de estrogeni la femeile cu cancer mamar (CM) în pre-/perimenopauză o reprezintă ablația ovariană. Ablația funcției ovariene poate fi realizată prin ovariectomie bilaterală sau prin utilizarea hormonului eliberator de gonadotropină (GnRH). Scop. Analiza rezultatelor imediate ale ovariectomiei în tratamentul complex adjuvant al pacientelor cu CM. Materiale și metode. Au fost studiate rezultatele la 61 paciente cu CM tratate în faza reproductivă cu vârsta între 22-48 de ani, care au fost supuse tratamentului hormonal, chimioterapic și ovariectomie. Rezultate. Pacientele cu tipul luminal A (RE+RP+Her2/neu-) au fost divizate în 3 loturi în dependență de metoda de tratament adjuvant: lotul I – chimio-/radioterapie + ovariectomie + tamoxifen – 31 paciente (50,81%); lotul II - chimio-/radioterapie + GnRH – 22 paciente (36,06%); lotul III - chimio-/radioterapie + tamoxifen – 8 paciente (13,11%). Dintre cele 31 de paciente din lotul I, date de progresare loco-regională în primii 2 ani nu s-au înregistrat la 29 de paciente, ceea ce constituie 93,54%; pentru lotul II – 19 din 22 (86,36%); lotul III – la 5 din 8 (62,5%). Concluzii. Ovariectomia în tratamentul complex adjuvant al pacientelor cu CM tip luminal A reprezintă metoda cu rata cea mai înaltă de reducere a cazurilor de progresare loco-regională comparativ cu alte metode de tratament hormonal.Introduction. The most effective method to stop the production of estrogen for patients in reproductive and perimenopausal phases presents ovarian ablation. Ovarian function ablation may be achieved by bilateral oophorectomy which leads to irreversible ablation of ovarian function with Gonadotropin releasing hormone analogues (GnRHAs). Purpose. Analysis of the immediate results of oophorectomy as adjuvant complex therapy for patients with breast cancer (BC). Material and methods. There were 61 patients with BC treated during the reproductive phases, aged 22-48 years, who were admitted within the Mastology Research Laboratory, Chemotherapy and Radiotherapy Departments of the Oncological Institute. Results. Patients with luminal A type (ER+PR+Her2/neu-) was were divided into 3 groups: group I – chemo-/ radiotherapy + oophorectomy + tamoxifen - 31 cases (50,81%); group II - chemo-/radiotherapy + GnRH - 22 cases (36,06%); group III - chemo-/radiotherapy + tamoxifen - 8 cases (13,11%). Of the 31 patients in group I, loco-regional progression data in the first 2 years have not been recorded in 29 patients, which is 93,54%; for group II - 19 cases (86,36%) of 22; for group III – 5 cases (62,5%) of 8. Conclusions. The role of oophorectomy in the adjuvant complex therapy for patients with luminal A type it is the method with the highest rate of reduction of cases of loco-regional progression comparated with other methods of hormonal treatment

Alternativă contemporană în tratamentul bolilor sexual transmisibile la bărbați (rezultate preliminare)

Summary The study was performed on the basis of the data accumulated while applying antibacterial treatment for 69 patients with sexual transmitted disease. The results showed the increased efficiency of clatithromycine in treatment of chronic uretritis caused by Chi. Trachomatis, Ur. Urealythicum and Мус. Hominis

Clinical-morphological and immunohistochemical tests in breast cancer patients of childbearing potential in the preoperative period

Catedra Oncologie, Hematologie şi Radioterapie, USMF „Nicolae Testemițanu”, Institutul Oncologic, Chişinău, Republica Moldova, Al XII-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova cu participare internațională 23-25 septembrie 2015Introducere: Tumorile glandei mamare sunt, de fapt, tumori hormono-dependente şi în cazul pacientelor aflate în fazele reproductive şi perimenopauză trebuie de redus maximal acţiunea estrogenior prin blocarea acestora sau prin reducerea numărului de estrogeni liberi circulanţi. Determinarea receptorilor hormonali (RH) este importantă în perioada preoperatorie prin trepanobiopsie pentru alegerea tacticii de tratament. Scopul studiului este studierea aspectelor investigațiilor clinico-morfologice şi imunohistochimice ale bolnavelor de cancer mamar (CM) faza reproductivă în perioada preoperatorie. Material şi metode: Tipul studiului realizat este descriptiv axat pe analiza investigațiilor clinico-morfologice şi imunohistochimice ale bolnavelor de CM faza reproductivă în perioada preoperatorie. Au fost studiate cartelele de ambulator şi fişele de observație clinică a 42 de paciente tratate de CM în faza reproductivă cu vârsta între 21-50 de ani, care s-au aflat în laboratorul Mamologie, secțiile Chimioterapie şi Radioterapie ale IMSP Institutul Oncologic. Rezultate: Clinic diagnosticul a fost suspectat la 37 paciente (88%); USG – la 26 paciente (74,25%); mamografic, suspecție de cancer a fost înregistrată la 20 din 25 (80%); morfologic (citologic sau histologic), diagnosticul a fost confirmat în toate 42 de cazuri, dintre care citologic – 27 cazuri (64,28%) din 42, iar în 11 cazuri s-a recurs la examenul histologic cu/fără examenul de urgență intraoperator sau trepanobiopsie la 4 paciente. Statutul imunohistochimic al tumorii a fost efectuat la 31 de paciente din 42 (73,80%) cu predominarea tumorilor ER+PgR+Her2neu- în 48,4% şi ER+PgR+Her2neu+ în 22,6%. Concluzii: Investigațiile clinico-paraclinice de bază cu o informativitate înaltă pentru depistarea CM în faza reproductivă sunt reprezentate de examenul clinic, USG, mamografia, examenul morfologic şi imunohistochimic cu determinarea RH.Introduction: Breast tumors are hormone-dependent tumors, therefore during reproductive and perimenopausal phases, patients require a maximal reduction of estrogen effects through blocking them or by reducing circulating free estrogen. Determination of hormone receptors (HR) is important in the preoperative period by trepanobiopsy for treatment strategy election. The purpose of study was research of the morphological and immunohistochemical tests in breast cancer (BC) patients of child-bearing potential in the pre-surgical period. Material and methods: This is a descriptive study focused on the analysis of clinical and morphological and immunohistochemical testing in breast cancer (BC) patients of child-bearing potential in the pre-surgical period. There were studied outpatient cards and inpatient records of 42 patients with BC treated during the reproductive phase, aged 21-50 years, who were admitted within the Mastology Research Laboratory, Chemotherapy and Radiotherapy Departments of the Oncological Institute. Results: Clinically, the diagnosis was suspected in 37 patients (88%); via ultrasound imaging in 26 patients (74.25%); mammographically suspected cancer was recorded in 20 of 25 (80%) subjects; morphologically (cytologically and histologically) the diagnosis was confirmed in all 42 cases, including cytology – 27 cases (64.28%) out of 42, and in 11 cases histology was used with/without emergency surgical intraoperative evaluation or trepanobiopsy in 4 patients. Tumor immunohistochemical profile was performed in 31 patients out of 42 (73.80%) with a prevalence of ER+PgR+Her2neu- tumors in 48.4% and PgR+ER+HER2neu+ in 22.6% of cases. Conclusions: Basic clinical and paraclinical examinations of a high informativity for BC detection during the reproductive phase are the following: clinical examination, ultrasound imaging, mammography, morphological and immunohistochemical tests with HR determination

Quantum information processes in protein microtubules of brain neurons

We study biologically ‘orchestrated’ coherent quantum processes in collections of protein microtubules of brain neurons, which correlate with, and regulate, neuronal synaptic and membrane activity. In this situation the continuous Schrodinger evolution of each such process terminates in accordance with the specific Diosi-Penrose (DP) scheme of ‘objective reduction’ (‘OR’) of the quantum state. This orchestrated OR activity (‘Orch OR’) is taken to result in moments of conscious awareness and/or choice. We analyze Orch OR in light of advances and developments in quantum physics, computational neuroscience and quantum biology. Much attention is also devoted to the ‘beat frequencies’ of faster microtubule vibrations as a possible source of the observed electroencephalographic (‘EEG’) correlates of consciousness