Resistance Pattern Of Urinary Tract Infection Bacterial Isolates To Selected Quinolones

The Quinolones inhibit bacteria by interacting with DNA topoisomerases (gyrases) of which four subunits (two A and B monomers) have been identified thus, inhibiting bacterial DNA gyrase. High level resistance to quinolones can be produced by serial exposure of bacteria to subinhibitory concentration. A Total of 408 suspected UTI and high vagina swab (HVS) samples were examined for bacteria and the isolates obtained tested against the newer quinolones. Prevalence of Bacterial isolates revealed Escherichia coli 110(92%) as the most isolated organism from urine, while Staphylococcus aureus 31(32%) was the most isolated species from HVS samples. Bacterial species such as coliforms 55(70%) and Klebsiella spp 42(84%), equally had high prevalence rate in urine samples. Pseudomonas aeroginosa 19(66%) was next to Staphylococcus aureus in terms of prevalence of isolated strains from HVS samples. The resistance pattern observed for these isolates, showed that the strains were least resistant to Ciprofloxacin, followed by Ofloxacin and Perfloxacin, while they were most resistant to Nalidixic acid. There was however no statistical significance (

Axillary fibroadenoma mimicking lymphadenopathy

No Abstract. Keywords: breast; fibroadenoma; axilla Nigerian Journal of Clinical Practice Vol. 11 (1) 2008: pp.73-7

Urinary tract pathology in some Schistosoma haematobium infected Nigerians

The parasitological investigation assessing the ova of Schistosoma haematobium in urine of 138 volunteers in Ihieve-Ogben, Edo State, Nigeria revealed a prevalence of 43 (31.2%). Children had ahigher prevalence of urinary schistosomiasis 30 (41.1%) than their adult counterparts 13 (20.0%). More volunteers had light intensity of infection 27 (19.6%) than heavy infection 16 (11.6%). Theultrasonographical investigation carried out on these 43 S. haematobium-infected volunteers revealed ten pathological conditions as abnormal wall thickness 24 (55.8%), abnormal shape 30 (69.8%), irregular bladder wall 12 (27.9%), masses 10 (23.3%), pseudopolyp 2 (4.7%), echogenic particles 30 (69.8%), residual volume 12 (27.9%), calcification 24 (55.8%), hydroureter 10 (23.3%) and hydronephrosis 8 (18.6%). These pathological conditions were higher in the volunteers with heavy intensity of infection than those with light infection. Also more pathological conditions were reported among the childrenthan their adult counterparts. Hydronephrosis and hydroureter were absent in the volunteers with light intensity of infection

Vitamin A status and ocular lesions in some rural Nigerians with onchocerciasis

The vitamin A and ocular lesions in 98 rural Nigerians who excreted microfilariae in their skin tissues and had at least one clinical manifestation of onchocerciasis were investigated. The highest prevalence rate of 18 (69.2%) occurred among adult males with leopard skin. The overall mean vitamin status of (20.3 ± 2.6 ìg/dl) was comparatively lower ( 2 = 41.0; p>0.05) than the control inhabitants (76.2.3 ± 3.8 ìg/dl). The mean vitamin status was higher among the infected children (22.7 ± 0.5 ìg/dl) than their adult counterparts (17.9 ± 6.1 ìg/dl). Also the mean vitamin A status of their infected children (22.7 ± 5.0 ìg/dl) was lower ( 2 = 31.1; p> 0.05) than their control subjects (73.5 ± 2.1 ìg/dl). The vitamin A status of the infected adults (17.9 ± 6.1 ìg/dl) was lower ( 2 = 47.2; p>0.05) than their control counterparts (78.9 ± 4.1ìg/dl). The mean microfilarial load of the different age groups of the infected volunteers showed negative correlation with the mean vitamin A status (r = -0.93). In all, five different ocular lesions namely cataract, optic atrophy, chroroidoretinitis, iriodocyclitis and sclerosing keratitis were reported. Visual impairment was absent and the ocular lesions were low among the children as they had only optic atrophy and sclerosing keratitis among the five different lesions encountered

Nasal Rhinosporidiosis: A Case Report And Outcome Of Therapy With Fluconazole

Background: Rhinosporidiosis is a rare disease in Nigeria. Its is widely believed to be caused by a fungus but this is disputed by many. Recent proof suggests that Rhinosporidiosis is caused by a cyanobacterium Study design: This is a clinical case report. Results: A 27-year old Nigerian male presented with an endonasal mass that mimicked neoplastic tumour. This mass showed significant good clinical response to therapy with oral fluconazole — an antifungal agent. Conclusion: This supports the likelihood of Rhinosporidiosis being of fungal aetiology or that cynobacterium is sensitive to fluconazole. Key Words: Rhinosporidiosis, fungus, cyanobacterium, fluconazole, Nigeria. Nig. J. Otorhinolaryngology Vol.1(1) 2004: 22-2

Prevalence Of Dyslipidaemia In Apparently Healthy Professionals In Asaba, South South Nigeria

Hypercholesterolaemia is a major risk factor for coronary heart disease (CHD) especially in industrialized societies. Coronary heart disease is becoming an increasing cause of death even in the developingworld. To determine the prevalence of dyslipidaemia in apparently healthy professionals in a developing economy. One hundred apparently healthy professionals were recruited from several professions by stratified random sampling. This population was believed to be at higher risk of dyslipidaemia considering their more likely “western diet” lifestyle. Total cholesterol, LDL-cholesterol, HDL-cholesterol and Triglycerides were determined using standard cholesterol LDLprecipitating reagents/kits. Themean age of the subjectswas 41.5 9 8.22 years (range 29 to 58 years) withmale to female ratio of 1:1.2. Mean total cholesterol was 180.69 36.248 mg/dl (4.67 0.94 mmol/L), LDL cholesterol 122.68 44.42 mg/dl (3.17 1.15mmol/L), HDL-cholesterol 37.47± 9.91 mg/dl (0.96 ± 0.26mmol/L) and Triglyceride 83.139±66.888mg/dl (0.94±0.76mmol/L). Using the Third Report of the NCEP Expert Panel on Detection. Evaluation and Treatment of high blood cholesterol in Adults (ATP III) definition and risk classification, 5% of the study population had hypercholesterolaemia, 23% elevated total serum cholesterol, 51% elevated LDL-cholesterol and 60% low HDL-cholesterol,with females recording better overall lipid profile. Dyslipidaemia was highly prevalent in the population studied, with low HDL- cholesterol being the most frequent lipid abnormality. Dyslipidaemia is becoming a serious health problem in the developing world also, even among the apparently healthy, and necessitates periodic lipid profile screening. Keywords: Prevalence, Dyslipidaemia, NCEP (National Cholesterol Education Programme),ATP III (Adult Treatment Panel III). Nigerian Journal of Clinical Practice Vol. 11 (4) 2008: pp. 330-33

Are athe symptoms of diabetic peripheral neuropathy in Nigerian patients objective? An evaluation using the United Kingdom screening test(UKST) and bio-thesiometry

No Abstract

Malignant diseases at Nnewi: the continuing scourge of late presentation

Background: Late presentation to hospital by patients with malignant diseases has remained a chronic problem. This work aims at studying the number of patients with malignant diseases that presented late to our centers as against those that presented early, to find out reasons for late presentation and to suggest ways of decreasing the incidence of late presentation.Patients and Methods: General surgical patients with malignant diseases seen between September 11, 2003 and September 10 2010 were recruited. Each lesion was clinically staged and a histological diagnosis obtained. At presentation, any lesion still within the primary site of origin and/or the regional lymph node was considered ‘early’. If the lesion had gone beyond the regional lymph node, it was considered ‘late’.Results: A total of 822 patients with confirmed malignant lesions were seen. Their ages ranged from 21 to 85 years. There were 364 males and 458 females. Majority of the patients did not acquire secondary education. Only 234 (28.5%) presented early. The remaining 588 patients (71.5%) presented late.Conclusions: Majority of the patients with malignant diseases in our community present late to hospital. Poverty and illiteracy on the part of the patients, as well as deceit of patients by quacks contribute significantly to these late presentations. Missed diagnosis by some doctors is also contributory. To decrease these late presentations, efforts should be directed at improving the general literacy level and the financial capability of the community as well as the diagnostic acumen of doctors