Ozonized sunflower seeds oil in the treatment of pressure ulcers

Ozone therapy can be defined as a bio-oxidative therapy in which the ozone is administered through different routes (gaseous, dissolved in water or oil) to obtain a beneficial effect in a living system sick. Ozone has many actions that have encouraged the use of this molecule in the field of dentistry, orthopedics and dermatology. In fact, ozone has the following properties: antimicrobial, immunostimulant, antihypoxic, biosynthetic, analgesic and hemostatic. The substrates containing unsaturated lipids react with the O2/O3 gas mixture causing the formation of derivatives ozonized therapeutically active. The therapeutic use of ozone gas for the treatment of skin diseases is unwieldy and for this reason the ozonated oils may represent a valid alternative. The oil extracted from the seeds of sunflower is characterized by a high percentage of unsaturated fatty acids and a low content of saturated fatty acids. Ozonation of sunflower seeds oil leads to the formation of ozonides of linoleic acid which possess high stability (up to 15 years). The daily application of ozonized oils in pressure ulcers has resulted in the rapid disappearance of bacterial superinfection and the formation of granulation tissue, which favored the reduction of the affected are

Monkeypox outbreak in Genoa, Italy: Clinical, laboratory, histopathologic features, management, and outcome of the infected patients

Since May 2022, multiple human Monkeypox cases were identified in nonendemic countries, mainly among men who have sex with men. We aimed to report the features, clinical course, management, and outcome of the Monkeypox cases diagnosed in the Dermatology and Infectious Disease Units of the San Martino Hospital, Genoa, Italy. We performed an observational study of the Monkeypox cases diagnosed from July 1 until August 31, 2022, collecting clinical, laboratory, and histological data. We studied 16 Monkeypox-infected men (14 homosexual, 2 bisexual) with a median age of 37 years. Three were HIV-infected. All patients reported multiple sexual partners and/or unprotected sex in the 2 weeks before the diagnosis. Most patients had prodromal signs/symptoms before the appearance of the skin/mucosal eruption, consisting of erythematous papules/vesicles/pustules in the anogenital area, which tended to erode evolving into crusts and ulcers. Lesions were often associated with local and/or systemic symptoms. Histopathology showed overlapping features in all cases: epidermal ulceration and dermal inflammatory infiltrate consisting of lymphocytes and neutrophils with an interstitial and perivascular/peri-adnexal pattern and endothelial swelling. Concomitant sexually transmitted infections (STIs) (gonococcal/nongonococcal proctitis and anal high-risk human papillomavirus [HR-HPV] infection) were frequent. Four patients were hospitalized, and one received specific treatment. The overall outcome was good. At the follow-up visit, three patients presented skin scars. Our series confirms the features of the current Monkeypox outbreak; however, different from other studies, we found a considerable rate of concomitant STIs, such as anal HR-HPV infection, that should be kept in mind because this persistent infection is the main cause of anal cancers