The secondary structure of apolipoprotein A-I on 9.6-nm reconstituted high-density lipoprotein determined by EPR spectroscopy.

Apolipoprotein A-I (ApoA-I) is the major protein component of high-density lipoprotein (HDL), and is critical for maintenance of cholesterol homeostasis. During reverse cholesterol transport, HDL transitions between an array of subclasses, differing in size and composition. This process requires ApoA-I to adapt to changes in the shape of the HDL particle, transiting from an apolipoprotein to a myriad of HDL subclass-specific conformations. Changes in ApoA-I structure cause alterations in HDL-specific enzyme and receptor-binding properties, and thereby direct the HDL particle through the reverse cholesterol transport pathway. In this study, we used site-directed spin label spectroscopy to examine the conformational details of the ApoA-I central domain on HDL. The motional dynamics and accessibility to hydrophobic/hydrophilic relaxation agents of ApoA-I residues 99-163 on 9.6-nm reconstituted HDL was analyzed by EPR. In previous analyses, we examined residues 6-98 and 164-238 (of ApoA-I's 243 residues), and combining these findings with the current results, we have generated a full-length map of the backbone structure of reconstituted HDL-associated ApoA-I. Remarkably, given that the majority of ApoA-I's length is composed of amphipathic helices, we have identified nonhelical residues, specifically the presence of a β-strand (residues 149-157). The significance of these nonhelical residues is discussed, along with the other features, in the context of ApoA-I function in contrast to recent models derived by other methods

STM/STS Study on 4a X 4a Electronic Charge Order of Superconducting Bi2Sr2CaCu2O8+d

We performed low-bias STM measurements on underdoped Bi2212 crystals, and confirmed that a two-dimensional (2D) superstructure with a periodicity of four lattice constants (4a) is formed within the Cu-O plane at T<Tc. This 4a X 4a superstructure, oriented along the Cu-O bonding direction, is nondispersive and more intense in lightly doped samples with a zero temperature pseudogap (ZTPG) than in samples with a d-wave gap. The nondispersive 4a X 4a superstructure was clearly observed within the ZTPG or d-wave gap, while it tended to fade out outside the gaps. The present results provide a useful test for various models proposed for an electronic order hidden in the underdoped region of high-Tc cuprates.Comment: 4 pages, submitted to J. Phys. Soc. Jp

Rotating Black Holes at Future Colliders. III. Determination of Black Hole Evolution

TeV scale gravity scenario predicts that the black hole production dominates over all other interactions above the scale and that the Large Hadron Collider will be a black hole factory. Such higher dimensional black holes mainly decay into the standard model fields via the Hawking radiation whose spectrum can be computed from the greybody factor. Here we complete the series of our work by showing the greybody factors and the resultant spectra for the brane localized spinor and vector field emissions for arbitrary frequencies. Combining these results with the previous works, we determine the complete radiation spectra and the subsequent time evolution of the black hole. We find that, for a typical event, well more than half a black hole mass is emitted when the hole is still highly rotating, confirming our previous claim that it is important to take into account the angular momentum of black holes.Comment: typoes in eqs(82)-(84) corrected; version to appear in Phys. Rev. D; references and a footnote added; same manuscript with high resolution embedded figures available on http://www.gakushuin.ac.jp/univ/sci/phys/ida/paper

Probing the Inflow/Out-flow and Accretion Disk of Cyg X-1 in the High State with HETG/Chandra

Cyg X-1 was observed in the high state at the conjunction orbital phase (0) with HETG/Chandra. Strong and asymmetric absorption lines of highly ionized species were detected, such as Fe XXV, Fe XXIV, Fe XXIII, Si XIV, S XVI, Ne X, and etc. In the high state the profile of the absorption lines are composed of an extended red wing and a less extended blue wing. The red wings of higher ionized species are more extended than that of lower ionized species. The detection of these lines provides a way to probe the properties of the flow around the companion and the black hole in Cyg X-1 during the high state. A broad emission feature around 6.5 keV was significantly detected from the both spectra of HETG/Chandra and PCA/RXTE. This feature appears to be symmetric and can be fitted with a Gaussian function rather than the Laor disk line model of fluorescent Fe K$_\alpha$ line from an accretion disk. The implications of these results on the structure of the accretion flow of Cyg X-1 in the high state are discussed.Comment: 16 pages, 4 fiugres. accepted for publication in the v597 n2 ApJ November 10, 2003 issu

A Model for Granular Texture with Steric Exclusion

We propose a new method to characterize the geometrical texture of a granular packing at the particle scale including the steric hindrance effect. This method is based on the assumption of a maximum disorder (entropy) compatible both with strain-induced anisotropy of the contact network and steric exclusions. We show that the predicted statistics for the local configurations is in a fairly agreement with our numerical data.Comment: 9 pages, 5 figure

Linear Toric Fibrations

These notes are based on three lectures given at the 2013 CIME/CIRM summer school. The purpose of this series of lectures is to introduce the notion of a toric fibration and to give its geometrical and combinatorial characterizations. Polarized toric varieties which are birationally equivalent to projective toric bundles are associated to a class of polytopes called Cayley polytopes. Their geometry and combinatorics have a fruitful interplay leading to fundamental insight in both directions. These notes will illustrate geometrical phenomena, in algebraic geometry and neighboring fields, which are characterized by a Cayley structure. Examples are projective duality of toric varieties and polyhedral adjunction theory

Heavy Higgs at Tevatron and LHC in Universal Extra Dimension Models

Universal Extra Dimension (UED) models tend to favor a distinctively heavier Higgs mass than in the Standard Model (SM) and its supersymmetric extensions when the Kaluza-Klein (KK) scale is not much higher than the electroweak one, which we call the weak scale UED, in order to cancel the KK top contributions to the T-parameter. Such a heavy Higgs, whose production through the gluon fusion process is enhanced by the KK top loops, is fairly model independent prediction of the weak scale UED models regardless of the brane-localized mass structure at the ultraviolet cutoff scale. We study its cleanest possible signature, the Higgs decay into a Z boson pair and subsequently into four electrons and/or muons, in which all the four-momenta of the final states can be measured and both the Z boson masses can be checked. We show that the weak scale UED model may account for the 2sigma excess of this event at ATLAS at the ZZ pair invariant mass around 250GeV, at which scale SM background is sufficiently small and the SM Higgs predicts too few events. We have also studied the Higgs mass 500GeV (and also 700GeV with \sqrt{s}=14TeV) and have found that we can observe significant resonance with the integrated luminosity 10fb^{-1} for six dimensional UED models.Comment: (v1) 36 pages, 9 figures, 6 tables; (v2) Accepted for publication in Phys. Rev. D, factor 2 error in (93) corrected, comments and references added, figures redrawn; (v3) Minor changes including typo corrections in eq.(15), final version appearing in PR

Superconducting Volume Fraction in Overdoped Regime of La_2-x_Sr_x_CuO_4_: Implication for Phase Separation from Magnetic-Susceptibility Measurement

We have grown a single crystal of La_2-x_Sr_x_CuO_4_ in which the Sr concentration, x, continuously changes from 0.24 to 0.29 in the overdoped regime and obtained many pieces of single crystals with different x values by slicing the single crystal. From detailed measurements of the magnetic susceptibility, chi, of each piece, it has been found that the absolute value of chi at the measured lowest temperature 2 K, |chi_2K_|, on field cooling rapidly decreases with increasing x as well as the superconducting (SC) transition temperature. As the value of |chi_2K_| is regarded as corresponding to the SC volume fraction in a sample, it has been concluded that a phase separation into SC and normal-state regions occurs in a sample of La_2-x_Sr_x_CuO_4_ in the overdoped regime.Comment: 4 pages, 3 figures, ver. 2 has been accepted in J. Phys. Soc. Jp