Novel antiprotozoal products: Imidazole and benzimidazole N-oxide derivatives and related compounds

The syntheses and biological evaluation of the first anti-protozoa imidazole N-oxide and benzimidazole N-oxide and their derivatives are reported. They were tested in vitro against two different protozoa, Trypanosoma cruzi and Trichomonas vaginalis. Derivative 7c, ethyl-1-(i-butyloxycarbonyloxy)-6-nitrobenzimid-azole-2-carboxylate, displayed activity on both protozoa. Lipophilicity and redox potential were experimentally determined in order to study the relationship with activity of the compounds. These properties are well related with the observed bioactivity. Imidazole and benzimidazole N-oxide derivatives are becoming leaders for further chemical modifications and advanced biological studies

Anticancerosos potenciales, análogos sulfónicos de ácido aspártico

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Procedimiento para la obtención de nuevos agentes colorantes pertenecientes a la familia de 2,2-dióxidos de pirazino [2,3-c]-1,2,6-tiadiazina 6,7-diaril sustituidos

Referencia OEPM: P8801074.-- Fecha de solicitud: 08/04/1988.-- Titular: Consejo Superior de Investigaciones Científicas (CSIC).Peer reviewe

Six-membered heterocycles: triazines, tetrazines and other polyaza systems

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El área de Ciencia y Tecnologías Químicas ¿Un área de químicas?

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