Prior induction of heme oxygenase-1 with glutathione depletor ameliorates the renal ischemia and reperfusion injury in the rat

AbstractHeme oxygenase (HO)-1 catalyzes the rate-limiting step in heme degradation releasing iron, carbon monoxide, and biliverdin. Induction of HO-1 occurs as an adaptive and protective response to oxidative stress. Ischemia and reperfusion (IR) injury seems to be mainly caused by the oxidative stress. In this study, we have examined whether prior induction of HO-1 with buthionine sulfoximine (BSO), a glutathione (GSH) depletor, affects the subsequent renal IR injury. BSO (2 mmol/kg body weight) was administered intraperitoneally into rats, the levels of HO-1 protein increased within 4 h after the injection. When BSO was administered into rats at 5 h prior to the renal 45 min of ischemia, the renal IR injury was assessed by determining the levels of blood urea nitrogen and serum creatinine, markers for renal injury, after 24 h of reperfusion. The renal injury was significantly improved as compared to the rats treated with IR alone. Administration of zinc-protoporphyrin IX, an inhibitor of HO activity, reduced the efficacy of BSO pretreatment on the renal IR injury. Our findings suggest that the prior induction of HO-1 ameliorates the subsequent renal IR injury

Ischemic Stroke in Acute Decompensated Heart Failure: From the KCHF Registry

[Background] Heart failure (HF) is a known risk factor for ischemic stroke, but data regarding ischemic stroke during hospitalization for acute decompensated HF (ADHF) are limited. [Methods and Results] We analyzed the data from a multicenter registry (Kyoto Congestive Heart Failure [KCHF] Registry) that enrolled 4056 consecutive patients with ADHF in Japan (mean age, 78 years; men, 2238 patients [55%]; acute coronary syndrome [ACS], 239 patients [5.9%]). We investigated the incidence and predictors of ischemic stroke during hospitalization for ADHF. During the hospitalization, 63 patients (1.6%) developed ischemic stroke. The median interval from admission to the onset of ischemic stroke was 7 [interquartile range: 2–14] days, and the most common underlying cause was cardioembolism (64%). Men (OR, 1.87; 95%CI, 1.11–3.24), ACS (OR, 2.31; 95%CI, 1.01–4.93), absence of prior HF hospitalization (OR, 2.21; 95%CI, 1.24–4.21), and high B‐type natriuretic peptide (BNP)/N‐terminal proBNP (NT‐proBNP) levels (above the median) at admission (OR, 3.15; 95%CI, 1.84–5.60) were independently associated with ischemic stroke. In patients without ACS, the independent risk factors for ischemic stroke were fully consistent with those in the main analysis. Higher quartiles of BNP/NT‐proBNP levels were significantly associated with higher incidence of ischemic stroke (P for trend, <0.001). Patients with ischemic stroke showed higher in‐hospital mortality, longer length of hospital stay, and poorer functional status at discharge. [Conclusions] During hospitalization for ADHF, 1.6% of the patients developed ischemic stroke. Men, ACS, absence of prior HF hospitalization, and high BNP/NT‐proBNP levels at admission were independently associated with ischemic stroke

Relationship between University and Local Society by Reviewing Comprehensive Plans

Recently the importance of university is recognized in local community. This research aims to clarify the relationship between university and local community by reviewing Comprehensive Plans. The results are as follows; 1)Relationship between university and local community can be classified into 10 fields like a industry, education and medical. And elements of relationship can be classified into 13 unformed elements(software) like organization, program, and 4 formed elements(hardware) like a stronghold, institution, space. 2)The number of description about university is unrelated with the classifications or populations of cities. 3)Many cases like organization, program, activity, business are implemented in the field like education, research. And, most of the accord concluded with university aims to develop local community or peoples

総合計画にみる地域社会と大学との連携に関する研究

Recently the importance of university is recognized in local community. This research aims to clarify the relationship between university and local community by reviewing Comprehensive Plans. The results are as follows; 1) Relationship between university and local community can be classified into 10 fields like a industry, education and medical. And elements of relationship can be classified into 13 unformed elements (software) like organization, program, and 4 formed elements (hardware) like a stronghold, institution, space. 2) The number of description about university is unrelated with the classifications or populations of cities. 3) Many cases like organization, program, activity, business are implemented in the field like education, research. And, most of the accord concluded with university aims to develop local community or peoples

Relationship between University and Local Society by Reviewing Comprehensive Plans

Recently the importance of university is recognized in local community. This research aims to clarify the relationship between university and local community by reviewing Comprehensive Plans. The results are as follows; 1) Relationship between university and local community can be classified into 10 fields like a industry, education and medical. And elements of relationship can be classified into 13 unformed elements (software) like organization, program, and 4 formed elements (hardware) like a stronghold, institution, space. 2) The number of description about university is unrelated with the classifications or populations of cities. 3) Many cases like organization, program, activity, business are implemented in the field like education, research. And, most of the accord concluded with university aims to develop local community or peoples