Acinetobacter Lwofii, an unusual cause of infectious pericarditis complicated with cardiac tamponade: a case report

Bacterial pericarditis can be considered a rare pathology, usually associated with cardiac procedures and, to a lesser extent, with immunosuppression and chronic diseases. The importance of its knowledge lies in the fact that mortality can reach up to 100% in untreated patients. Once diagnosed, pericardiocentesis and administration of intravenous antimicrobial therapy are mandatory for the prevention of its complications, which include cardiac tamponade and sepsis. Here we present an exceptional case of infectious pericarditis due to Acinetobacter Lwoffii in an older adult, which was complicated by pericardial effusion and cardiac tamponade

Relationship of troponins with in-hospital mortality in adults with covid-19 in a colombian caribbean city: a nested case-control study

Background: myocardial injury, characterized by elevated cardiac troponin levels, is a common finding in severe COVID-19 cases, occurring in up to 38% of patients. It has been identified as an independent predictor of mortality. Objective: our aim is to assess the predictive value of cardiac troponin levels for in-hospital mortality among adults hospitalized with COVID-19 in Barranquilla, Colombia, during the period from January to June 2021. Methods: this study is a nested case-control analysis within a retrospective cohort. It encompasses individuals aged 18 and older with a confirmed diagnosis of COVID-19 who were hospitalized between January and June 2021 (n = 358). We describe the demographic and paraclinical characteristics of the patients and their association with outcomes at the time of discharge. We also estimate the diagnostic accuracy, including sensitivity, specificity, and predictive values, of elevated troponin levels in predicting in-hospital mortality. Results: patients with elevated troponin levels demonstrated a significantly increased risk of in-hospital mortality (OR: 9.4; 95% CI: 5.5-16.0; p < 0.05) and had a notably higher in-hospital mortality rate (55.6%) compared to those with non-elevated troponin levels (11.7%). The troponin biomarker exhibited a sensitivity of 77.9% and specificity of 72.7%, with positive and negative predictive values of 55.6% and 88.3%, respectively, for in-hospital mortality. Conclusion: troponin elevation in subjects with COVID-19 is positively related to in-hospital mortality, independently of other conditions such as age group, comorbidities, or oxygen therapy requirement

Lupus Eritematoso Sistémico: generalidades sobre su fisiopatología, clínica, abordaje diagnóstico y terapéutico

El Lupus Eritematoso Sistémico (LES) es uno de los prototipos de las enfermedades autoinmunes, compromete principalmente al sexo femenino, con una proporción 9:1 mujer-hombre. Se caracteriza por la formación de autoanticuerpos con la participación de la inmunidad adaptativa e innata, en interacción con los factores genéticos y medioambientales. Estos autoanticuerpos son parte central de la fisiopatología de la enfermedad, causando desde compromiso orgánico leve hasta compromiso multisistémico grave. El diagnóstico es clínico, orientado por una anamnesis detallada, un examen físico exhaustivo y los marcadores de autoinmunidad; eventualmente podría apoyarse en criterios clasificatorios de algunas sociedades científicas. La actual revisión pretende destacar las generalidades sobre la enfermedad, haciendo énfasis en su fisiopatología, presentación clínica, y su abordaje diagnóstico y terapéutico, sirviendo de apoyo para la formación médica integral en beneficio de los pacientes

Relationship of troponins with in-hospital mortality in adults with covid-19 in a colombian caribbean city: a nested case-control study

Background: myocardial injury, characterized by elevated cardiac troponin levels, is a common finding in severe COVID-19 cases, occurring in up to 38% of patients. It has been identified as an independent predictor of mortality. Objective: our aim is to assess the predictive value of cardiac troponin levels for in-hospital mortality among adults hospitalized with COVID-19 in Barranquilla, Colombia, during the period from January to June 2021. Methods: this study is a nested case-control analysis within a retrospective cohort. It encompasses individuals aged 18 and older with a confirmed diagnosis of COVID-19 who were hospitalized between January and June 2021 (n = 358). We describe the demographic and paraclinical characteristics of the patients and their association with outcomes at the time of discharge. We also estimate the diagnostic accuracy, including sensitivity, specificity, and predictive values, of elevated troponin levels in predicting in-hospital mortality. Results: patients with elevated troponin levels demonstrated a significantly increased risk of in-hospital mortality (OR: 9.4; 95% CI: 5.5-16.0; p &lt; 0.05) and had a notably higher in-hospital mortality rate (55.6%) compared to those with non-elevated troponin levels (11.7%). The troponin biomarker exhibited a sensitivity of 77.9% and specificity of 72.7%, with positive and negative predictive values of 55.6% and 88.3%, respectively, for in-hospital mortality. Conclusion: troponin elevation in subjects with COVID-19 is positively related to in-hospital mortality, independently of other conditions such as age group, comorbidities, or oxygen therapy requirement