ENUMERATIVE TECHNIQUES IN TOPOLOGICAL OPTIMIZATION OF COMPUTER NETWORKS SUBJECT TO FAULT TOLERANCE AND RELIABILITY

In this paper, we propose one algorithm for optimizing the terminal reliability and another for optimizing the network reliability while improving the fault tolerance aspects of the designed networks. Experimental results obtained from a set of randomly generated networks using the proposed algorithms are presented and compared to those obtained using the existing techniques [1], [2]. It is shown that improving the fault tolerance of a network can be achieved while optimizing its reliability however at the expense of a reasonable increase in the overall cost of the network

The Use of Enumerative Techniques in Topological Optimization of Computer Networks Subject to Fault Tolerance and Reliability

Topological optimization of computer networks is concerned with the design of a network by selecting a subset of the available set of links such that the fault tolerance and reliability aspects are maximized while a cost constraint is met. A number of enumeration-based techniques were proposed to solve this problem. They are based on enumerating all the possible paths (for Terminal reliability) and all the spanning trees (for ��Network reliability). Existing enumeration-based techniques for solving this network optimization problem ignore the fault-tolerance aspect in their solution. Fault tolerance is an important network design aspect. A fault tolerant network is able to function even in the presence of some faults in the network. In this paper, we propose one algorithm for optimizing the terminal reliability and another for optimizing the network reliability while improving the fault tolerance aspects of the designed networks. Experimental results obtained from a set of randomly generated networks using the proposed algorithms are presented and compared to those obtained using the existing techniques [1], [2]. It is shown that improving the fault tolerance of a network can be achieved while optimizing its reliability however at the expense of a reasonable increase in the overall cost of the network while remaining within a maximum pre-specified cost constraint

ENUMERATIVE TECHNIQUES IN TOPOLOGICAL OPTIMIZATION OF COMPUTER NETWORKS SUBJECT TO FAULT TOLERANCE AND RELIABILITY

In this paper, we propose one algorithm for optimizing the terminal reliability and another for optimizing the network reliability while improving the fault tolerance aspects of the designed networks. Experimental results obtained from a set of randomly generated networks using the proposed algorithms are presented and compared to those obtained using the existing techniques [1], [2]. It is shown that improving the fault tolerance of a network can be achieved while optimizing its reliability however at the expense of a reasonable increase in the overall cost of the network

ENUMERATIVE TECHNIQUES IN TOPOLOGICAL OPTIMIZATION OF COMPUTER NETWORKS SUBJECT TO FAULT TOLERANCE AND RELIABILITY

In this paper, we propose one algorithm for optimizing the terminal reliability and another for optimizing the network reliability while improving the fault tolerance aspects of the designed networks. Experimental results obtained from a set of randomly generated networks using the proposed algorithms are presented and compared to those obtained using the existing techniques [1], [2]. It is shown that improving the fault tolerance of a network can be achieved while optimizing its reliability however at the expense of a reasonable increase in the overall cost of the network

The Use of Enumerative Techniques in Topological Optimization of Computer Networks Subject to Fault Tolerance and Reliability

Topological optimization of computer networks is concerned with the design of a network by selecting a subset of the available set of links such that the fault tolerance and reliability aspects are maximized while a cost constraint is met. A number of enumeration-based techniques were proposed to solve this problem. They are based on enumerating all the possible paths (for Terminal reliability) and all the spanning trees (for ��Network reliability). Existing enumeration-based techniques for solving this network optimization problem ignore the fault-tolerance aspect in their solution. Fault tolerance is an important network design aspect. A fault tolerant network is able to function even in the presence of some faults in the network. In this paper, we propose one algorithm for optimizing the terminal reliability and another for optimizing the network reliability while improving the fault tolerance aspects of the designed networks. Experimental results obtained from a set of randomly generated networks using the proposed algorithms are presented and compared to those obtained using the existing techniques [1], [2]. It is shown that improving the fault tolerance of a network can be achieved while optimizing its reliability however at the expense of a reasonable increase in the overall cost of the network while remaining within a maximum pre-specified cost constraint

The Use of Enumerative Techniques in Topological Optimization of Computer Networks Subject to Fault Tolerance and Reliability

Topological optimization of computer networks is concerned with the design of a network by selecting a subset of the available set of links such that the fault tolerance and reliability aspects are maximized while a cost constraint is met. A number of enumeration-based techniques were proposed to solve this problem. They are based on enumerating all the possible paths (for Terminal reliability) and all the spanning trees (for ��Network reliability). Existing enumeration-based techniques for solving this network optimization problem ignore the fault-tolerance aspect in their solution. Fault tolerance is an important network design aspect. A fault tolerant network is able to function even in the presence of some faults in the network. In this paper, we propose one algorithm for optimizing the terminal reliability and another for optimizing the network reliability while improving the fault tolerance aspects of the designed networks. Experimental results obtained from a set of randomly generated networks using the proposed algorithms are presented and compared to those obtained using the existing techniques [1], [2]. It is shown that improving the fault tolerance of a network can be achieved while optimizing its reliability however at the expense of a reasonable increase in the overall cost of the network while remaining within a maximum pre-specified cost constraint

Reliability based Topological Optimization of Computer Networks - Part II: Iterative Techniques

Topological optimization of computer networks is concerned with the design of a network by selecting a subset of the available set of links such that the fault tolerance and reliability aspects are maximized while a cost constraint is met. A number of enumerative and iterative based techniques were proposed to solve this problem. In this paper (Part II), we present and compare the different proposed iterative techniques for optimizing different aspects (reliability, fault tolerance, and cost) of the designed networks

Reliability based Topological Optimization of Computer Networks - Part II: Iterative Techniques

Topological optimization of computer networks is concerned with the design of a network by selecting a subset of the available set of links such that the fault tolerance and reliability aspects are maximized while a cost constraint is met. A number of enumerative and iterative based techniques were proposed to solve this problem. In this paper (Part II), we present and compare the different proposed iterative techniques for optimizing different aspects (reliability, fault tolerance, and cost) of the designed networks

The role of microRNAs in defining LSECs cellular identity and in regulating F8 gene expression

Introduction: Coagulation Factor VIII (FVIII) plays a pivotal role in the coagulation cascade, and deficiencies in its levels, as seen in Hemophilia A, can lead to significant health implications. Liver sinusoidal endothelial cells (LSECs) are the main producers and contributors of FVIII in blood, a fact we have previously elucidated through mRNA expression profiling when comparing these cells to other endothelial cell types.Methods: Our current investigation focuses on small microRNAs, analyzing their distinct expression patterns across various endothelial cells and hepatocytes.Results: The outcome of this exploration underscores the discernible microRNAs expression differences that set LSECs apart from both hepatocytes (193 microRNAs at p < 0.05) and other endothelial cells (72 microRNAs at p < 0.05). Notably, the 134 and 35 overexpressed microRNAs in LSECs compared to hepatocytes and other endothelial cells, respectively, shed light on the unique functions of LSECs in the liver.Discussion: Our investigation identified a panel of 10 microRNAs (miR-429, miR-200b-3p, miR-200a-3p, miR-216b-5p, miR-1185-5p, miR-19b-3p, miR-192-5p, miR-122-5p, miR-30c-2-3p, and miR-30a-5p) that distinctly define LSEC identity. Furthermore, our scrutiny extended to microRNAs implicated in F8 regulation, revealing a subset (miR-122-5p, miR-214-3p, miR-204-3p, and miR-2682-5p) whose expression intricately correlates with F8 expression within LSECs. This microRNA cohort emerges as a crucial modulator of F8, both directly through suppression and indirect effects on established F8-related transcription factors. The above microRNAs emerged as potential targets for innovative therapies in Hemophilia A patients