4,055 research outputs found
Quantum electrodynamics in a whispering-gallery microcavity coated with a polymer nanolayer
Quasi-transverse-electric and -transverse-magnetic fundamental whispering
gallery modes in a polymer-coated silica microtoroid are theoretically
investigated and demonstrated to possess very high-quality factors. The
existence of a nanometer-thickness layer not only evidently reduces the cavity
mode volume but also draws the maximal electric field's position of the mode to
the outside of the silica toroid, where single quantum dots or nanocrystals are
located. Both effects result in a strongly enhanced coherent interaction
between a single dipole (for example, a single defect center in a diamond
crystal) and the quantized cavity mode. Since the coated microtoroid is highly
feasible and robust in experiments, it may offer an excellent platform to study
strong-coupling cavity quantum electrodynamics, quantum information, and
quantum computation
Antibacterial 45S5 BioglassÂź-based scaffolds reinforced with genipin cross-linked gelatin for bone tissue engineering
45S5 BioglassÂź (BG) scaffolds with high porosity (>90%) were coated with genipin cross-linked gelatin (GCG) and further incorporated with poly(p-xylyleneguanidine) hydrochloride (PPXG). The obtained GCG coated scaffolds maintained the high porosity and well interconnected pore structure. A 26-fold higher compressive strength was provided to 45S5 BG scaffolds by GCG coating, which slightly retarded but did not inhibit the in vitro bioactivity of 45S5 BG scaffolds in SBF. Moreover, the scaffolds were made antibacterial against both Gram-positive and Gram-negative bacteria by using polyguanidine, i.e. PPXG, in this study. Osteoblast-like cells (MG-63) were seeded onto PPXG and GCG coated scaffolds. PPXG was biocompatible with MG-63 cells at a low concentration (10 ÎŒg mLâ1). MG-63 cells were shown to attach and spread on both uncoated and GCG coated scaffolds, and the mitochondrial activity measurement indicated that GCG coating had no negative influence on the cell proliferation behavior of MG-63 cells. The developed novel antibacterial bioactive 45S5 BG-based composite scaffolds with improved mechanical properties are promising candidates for bone tissue engineering
Is cash king for sales compensation plans? Evidence from a large-scale field intervention
The pervasive use of merchandise (i.e., non-cash) incentives in sales compensation plans is an empirical and theoretical puzzle given the supposed superiority of cash incentives in the standard theory (i.e., principal-agent models) and the scant, and contradictory empirical evidence. We conducted a large scale field intervention that switched 580 salespeople at a large frozen food manufacturer away from their cash plus â merchandise pointsâ bonus to a commensurate all-cash bonus. After controlling for salesperson, seasonality, year, and target effects, we estimated that sales, on average, dropped by 4.36%. Further, we estimated individual-level sales changes and effort changes to validate our incentive-effort-sales causal chain. Our results show that the top salespeople experienced the largest drops. A post-intervention survey of social and individual difference variables reveals that salespeople from households with more discretionary financial resources, and those who think more abstractly about the uses of cash income exhibited smaller reductions in effort and sales. While the absence of a control group prevents us from making strong causal inferences, this set of results nevertheless provides descriptive and suggestive evidence for separate mental accounts as the most promising explanation for the greater utility provided by merchandise incentives
Strain-engineering in Germanium membranes towards light sources on Silicon
Bi-axially strained Germanium (Ge) is an ideal material for Silicon (Si) compatible light sources, offering exciting applications in optical interconnect technology. By employing a novel suspended architecture with an optimum design on the curvature, we applied a biaxial tensile strain as large as 0.85% to the central region of the membrane
Reticular synthesis and the design of new materials
The long-standing challenge of designing and constructing new crystalline solid-state materials from molecular building blocks is just beginning to be addressed with success. A conceptual approach that requires the use of secondary building units to direct the assembly of ordered frameworks epitomizes this process: we call this approach reticular synthesis. This chemistry has yielded materials designed to have predetermined structures, compositions and properties. In particular, highly porous frameworks held together by strong metal-oxygen-carbon bonds and with exceptionally large surface area and capacity for gas storage have been prepared and their pore metrics systematically varied and functionalized.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62718/1/nature01650.pd
PAHâDNA Adducts in Cord Blood and Fetal and Child Development in a Chinese Cohort
Polycyclic aromatic hydrocarbons (PAHs) are an important class of toxic pollutants released by fossil fuel combustion. Other pollutants include metals and particulate matter. PAHâDNA adducts, or benzo[a]pyrene (BaP) adducts as their proxy, provide a chemical-specific measure of individual biologically effective doses that have been associated with increased risk of cancer and adverse birth outcomes. In the present study we examined the relationship between prenatal PAH exposure and fetal and child growth and development in Tongliang, China, where a seasonally operated coal-fired power plant was the major pollution source. In a cohort of 150 nonsmoking women and their newborns enrolled between 4 March 2002 and 19 June 2002, BaPâDNA adducts were measured in maternal and umbilical cord blood obtained at delivery. The number of gestational months occurring during the period of power plant operation provided a second, more general measure of exposure to plant emissions, in terms of duration. High PAHâDNA adduct levels (above the median of detectable adduct level) were associated with decreased birth head circumference (p = 0.057) and reduced childrenâs weight at 18 months, 24 months, and 30 months of age (p < 0.05), after controlling for potential confounders. In addition, in separate models, longer duration of prenatal exposure was associated with reduced birth length (p = 0.033) and reduced childrenâs height at 18 (p = 0.001), 24 (p < 0.001), and 30 months of age (p < 0.001). The findings suggest that exposure to elevated levels of PAHs, with the Tongliang power plant being a significant source, is associated with reduced fetal and child growth in this population
The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria
Components of the death receptors-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets. In this study, we report that the long isoform of the cellular FLICE-inhibitory protein (c-FLIPL), a well- known inhibitor of the extrinsic cell death initiator caspase-8, localizes at the endoplasmic reticulum (ER) and mitochondria-associated membranes (MAMs). ER morphology was disrupted and ER Ca2+-release as well as ER-mitochondria tethering were decreased in c-FLIP-/- mouse embryonic fibroblasts (MEFs). Mechanistically, c-FLIP ablation resulted in enhanced basal caspase-8 activation and in caspase-mediated processing of the ER-shaping protein reticulon-4 (RTN4) that was corrected by re-introduction of c-FLIPL and caspase inhibition, resulting in the recovery of a normal ER morphology and ER-mitochondria juxtaposition. Thus, the caspase-8 inhibitor c-FLIPL emerges as a component of the MAMs signaling platforms, where caspases appear to regulate ER morphology and ER-mitochondria crosstalk by impinging on ER-shaping proteins like the RTN4
Observation of a One-Dimensional Spin-Orbit Gap in a Quantum Wire
Understanding the flow of spins in magnetic layered structures has enabled an
increase in data storage density in hard drives over the past decade of more
than two orders of magnitude1. Following this remarkable success, the field of
'spintronics' or spin-based electronics is moving beyond effects based on local
spin polarisation and is turning its attention to spin-orbit interaction (SOI)
effects, which hold promise for the production, detection and manipulation of
spin currents, allowing coherent transmission of information within a device.
While SOI-induced spin transport effects have been observed in two- and
three-dimensional samples, these have been subtle and elusive, often detected
only indirectly in electrical transport or else with more sophisticated
techniques. Here we present the first observation of a predicted 'spin-orbit
gap' in a one-dimensional sample, where counter-propagating spins, constituting
a spin current, are accompanied by a clear signal in the easily-measured linear
conductance of the system.Comment: 10 pages, 5 figures, supplementary informatio
Unlocking the potential of nanoscale sulfur in sustainable agriculture
The global population is growing rapidly, which poses a significant challenge to food security. Innovation in agricultural technologies is necessary to achieve sustainable development in agriculture and combat food insecurity. Nanotechnology has emerged as a promising tool in agriculture; compared to conventional agricultural chemicals, demonstrated benefits include increased efficiency of delivery and utilization of both nutrients and pesticides, as well as nanoscale-specific stimulation of stress tolerance pathways. Among the many studied nanomaterials, nano-sulfur has demonstrated superior effects at enhancing plant resilience to pathogens and abiotic stresses, as well as improving plant growth and nutritional quality of edible tissues. A number of published studies have investigated the physiological effects (growth promotion, disease resistance) of single or several sulfur and sulfide compounds on crop species. However, there is no systematic analysis of this literature, including the effects and specific mechanisms of various sulfur forms in agricultural applications. In this review, we will discuss the effects of sulfur (including nano-sulfur) on crop species, the underlying mechanisms of action for their transport and transformation in the soil-plant system, and evaluate their suitability in sustainable agricultural development. Additionally, we discuss the current challenges and knowledge gaps for nanoscale sulfur use in agriculture, and describe future research directions to advance our understanding of the sustainable use of this material at the scale of individual fields
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