Robust Conceptual Design of Transonic Airfoils

This paper describes an integrated, multi-fidelity analysis and heuristic design approach that can be used to derive initial airfoil designs for transonic flight. If successful, the final result is a geometry that can be expected to produce reasonable aerodynamic performance when used with higher order analysis methods. A key aspect of the methodology is the use of a sonic-plateau pressure distribution as the target distribution for inverse design. The sonic- plateau distribution is easily parameterized and has the advantage of automatically resulting in a smooth airfoil shape without any discontinuities built into the surface due to the presence of a shock in the target pressure distribution. Inverse design is performed on each airfoil using a parametrically defined pressure distribution at a reduced lift coefficient and Mach number from the design condition. The methodology is demonstrated by designing an airfoil at 38% of the wing semispan for a 737-200-like aircraft. The demonstration problem shows that the methodology is able to achieve rapid and robust convergence to the solution. The calculated designed airfoil was found to be sufficiently higher than Mach number, and the maximum thickness was close to the targeted value

INTRODUCTION TO FARM RECORDS AND ACCOUNTING

Agricultural Finance,

PRECISION AGRICULTURE: CURRENT ECONOMIC AND ENVIRONMENTAL ISSUES

Research and Development/Tech Change/Emerging Technologies,

NORTHLAND FOODS: PLANNING THE END A DECISION CASE

Agribusiness,

Minnesota Agricultural Economist 696

Agricultural Finance,

IMPROVING THE EVALUATION OF FARM ACCOUNTING SOFTWARE

Agricultural Finance,

Energy, climate and water in the 21st century – Texas and Florida share a strong connection with future challenges in the Earth sciences

Bureau of Economic Geolog

The tapeworm interactome: inferring confidence scored protein-protein interactions from the proteome of Hymenolepis microstoma

BACKGROUND: Reference genome and transcriptome assemblies of helminths have reached a level of completion whereby secondary analyses that rely on accurate gene estimation or syntenic relationships can be now conducted with a high level of confidence. Recent public release of the v.3 assembly of the mouse bile-duct tapeworm, Hymenolepis microstoma, provides chromosome-level characterisation of the genome and a stabilised set of protein coding gene models underpinned by bioinformatic and empirical data. However, interactome data have not been produced. Conserved protein-protein interactions in other organisms, termed interologs, can be used to transfer interactions between species, allowing systems-level analysis in non-model organisms. RESULTS: Here, we describe a probabilistic, integrated network of interologs for the H. microstoma proteome, based on conserved protein interactions found in eukaryote model species. Almost a third of the 10,139 gene models in the v.3 assembly could be assigned interaction data and assessment of the resulting network indicates that topologically-important proteins are related to essential cellular pathways, and that the network clusters into biologically meaningful components. Moreover, network parameters are similar to those of single-species interaction networks that we constructed in the same way for S. cerevisiae, C. elegans and H. sapiens, demonstrating that information-rich, system-level analyses can be conducted even on species separated by a large phylogenetic distance from the major model organisms from which most protein interaction evidence is based. Using the interolog network, we then focused on sub-networks of interactions assigned to discrete suites of genes of interest, including signalling components and transcription factors, germline multipotency genes, and genes differentially-expressed between larval and adult worms. Results show not only an expected bias toward highly-conserved proteins, such as components of intracellular signal transduction, but in some cases predicted interactions with transcription factors that aid in identifying their target genes. CONCLUSIONS: With key helminth genomes now complete, systems-level analyses can provide an important predictive framework to guide basic and applied research on helminths and will become increasingly informative as new protein-protein interaction data accumulate