Evaluation Of Degradation Of Bioabsorbable Polycaprolactone Used In Rapid Prototyping For Medical Application

Tissue engineering is an emerging field on regenerative medicine to try to solve the end-stage of organ and tissue failure. This kind of method was developed as an alternative therapy for the treatment of tissue loss or organ failure resolving the shortage on transplantation therapy. Bone and cartilage tissue are under extensive investigation in tissue engineering research. A significant progress has been done on the recent years, although one major obstacle is to maintain the constructed tissue alive in vitro as well as in vivo. For this kind of problem a large number of bioresorbable materials and scaffolds design have been developed. They must have some especial characteristics such as three-dimensional features and highly porous structure with interconnection, biocompatibility and degradation control. Additionally, they shall present suitable surface for attachment of cells, growth and differentiation. Trying to enhance these properties it was used a bioabsorbable polymer approved by the FDA, polycaprolactone. Selective Laser Sintering (SLS) was used with a deflected laser beam selectively to scan over the powder surface following the cross-sequential profiles carried by the slice data. The interaction of the laser beam with the powder elevates the powder temperature to reach the glass-transition temperature, causing surfaces in contact to deform and fuse together. CAD models of different scaffolds were made to evaluate the most commons problems such shrinkage and distortion. In this case we observed oversize of the scaffold walls, reducing the pores size. To evaluate the material degradation rate it was used the SBF solution on 37°C on different times of immersion. After that the samples were weighted and observed on the SEM. We could see a reduction of mass percentage and it was visible bulk degradation of the material on the microscope observation. This study allows some properties of bioabsorbable polymer used in rapid prototyping (SLS), but it must be done citotoxicity tests to evaluate the biocompatibility. © 2008 Taylor & Francis Group.101105Berry, E., Preliminary experience with medical applications of rapid prototyping by selective laser sintering (1997) Med Eng Phys, 19 (1), pp. 90-96Bezwada, R.S., Monocryl suture, a new ultrapliable absorbable monofilament suture (1995) Biomaterials, 16, pp. 1141-1148(2007) InVesalius software, , http://www.cenpra.gov.br, CenPRA , Available atChen, D.R., Polycaprolactone microparticles and their biodegradation (2000) Polymer Degradation and Stability, 67, pp. 455-459Chen, J.H., (1995) Polym Mater Sci Eng, 11, p. 79Darney, P.D., Clinical evaluation of the Capronor contraceptive implant: Preliminary report (1989) Am J Obstet Gynecol, 160, pp. 1292-1295Das, S., Freeform fabrication of nylon-6 tissue engineering scaffolds (2003) Rapid Prototyping J, 9 (1), pp. 43-49Deckard, C.R., (1986) Generation by Layerwise Selective Sintering, , MS thesis, Department of Mechanical Engineering, University of Texas at AustinDeckard, C.R., (1988) Selective Laser Sintering, , PhD dissertation, Department of Mechanical Engineering, University of Texas at AustinDeshpande, A.A., Bioerodible polymers for ocular drug delivery (1998) Crit Rev Therapeutic Drug Carrier Systems, 15 (4), pp. 381-420Engelberg, I., Kohn, J., Physicomechanical properties of degradable polymers used in medical applications:a comparative study (1991) Biomaterials, 12 (3), pp. 292-304Li, Y., Effects of filtration seeding on cell density, spatial distribution and proliferation in nonwoven fibrous matrices (2001) Biotechnol. 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Comparison Of Five Rapid Prototype Techniques (sls/fdm/dlp/3dp/polyjet)

The rapid prototyping technology is an effective tool in making models for use in medical applications. This paper proposes the study of rapid prototyping processes through the analysis of the technical features measuring a standard model. The processes evaluated are SLS (Selective Laser Sintering), FDM (Fused Deposition Modeling), DLP (Digital Light Processor), PolyJet and 3DP (Tridimensional Printer). This article aims to describe the characteristics of materials used in these processes, such as roughness, hardness, surface finish and dimensional analysis (using scanning inspection). This study also brings a brief description of the concepts involved in each process and what parameters should be observed during processing. © 2012 Taylor & Francis Group, London.573580Chua, K., Leong, K.F., Lim, C.S., (2010) Rapid Prototyping: Principles and Applications, p. 512. , 3rd Edition. Singapore: World Scientific Publishing Co. Pte. Ltd., 2010Souza, A.F., Ulbrich, C.B.L., (2009) Engenharia Integrada Por Computador e Sistemas CAD/CAM/CNC - Princípios e Aplicações, p. 332. , São Paulo: EditoraArtliber Ltda, 2009Volpato, N., (2007) Prototipagem Rapida: Tecnologias e Aplicações, p. 244. , São Paulo: Edgard Blucher, 2007Wohlers, T., (2008) Wohlers Report 2008, , State of the Industry, AnnualWorldwide Progress Repor

Phb Obtained By Selective Laser Sintering For Bone Tissue Engineering

[No abstract available]31556Shishatskaya, E.I., (2004) J Mater Sci Mater Med, 15, p. 719Volova, T., (2003) Biochemical Eng J, 16, p. 125Lucchesi, C., (2007) J Mater Sci Mater Med, p. 10Davies, J.E., (1999) Bone Engineering: Based on the Proceeding of the Bone Engineering Workshop Held in Toronto, , Hong Kong, Rainbow Graphic and Printin

Three-dimensional Porous Phb Scaffolds Obtained By Sls

[No abstract available]41977Sachlos, E., (2003) Biomaterials, 24, p. 1487Williams, J.M., (2005) Biomaterials, 26, p. 4817Hasirci, V., (2001) Journal of Biotechnology, 86, p. 13