Oxidative damage on the testes of adult rats by sodium metabisulfite (MBS)

The effect of sodium metabisulfite (MBS, Na2S2O5) on the level of malondialdehyde (MDA), testes weight and the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) as well as the level of glutathione (GSH) were investigated in the testes of Wistar albino rats. The study was performed to elucidate the effect of MBS (520 mg/kg/day) ingestion on lipid peroxidation and the antioxidant enzymes activities. The results showed that MDA level as well as the activity of SOD was significantly increased in MBS-treated rats whereas the weight of the testes as well as the level of GSH was not significantly affected. However, there was significant reduction in the activity of CAT in the MBS-treated rats compared to the control. The presented data showed that ingestion of MBS has adverse effect on testes as it induced oxidative damage, reflected by increase lipid peroxidation and impairment in the activities of antioxidant enzymes.Keywords: Sodium metabisulfite, testes, lipid peroxidation, glutathione, catalase, superoxide dismutas

Antioxidant defense of zinc acetate supplementation on the brain of protein–undernourished rats.

The effect of zinc on brain weight, glutathione (GSH) level, catalase activity and lipid peroxidation in the brain of protein-undernourished (PU) rats was investigated following the ad libitum ingestion of zinc acetate (30 mg/L) in drinking water for two weeks. Results show that protein-undernutrition induced significant reductions (

Mandibular morphological changes associated with actinomycesviscosus infection in a West African dwarf goat in Nigeria

This report described the morphological alterations on the mandible in a 3- year- old West African dwarfdoe caused by Actinomycesviscosus infection. The animal recovered after treatment but was later culled and the head submitted to the Department of Veterinary Anatomy. Hot water maceration of the lower jaw and the histology of the right mandibular lymph nodewere carried out. The mandible revealed worn off periodontal membrane, lodgment of tough feed materials in the gingival-alveolar spaces as well as a fistulous tract of about 4mm in diameter with uneven ridges at its edges ventral to the 2nd molar on the lateral aspect of the horizontal ramus of the mandible. Also, the alveolar borders of both sides of the mandible were worn off with the right side forming a thicker ridge than the left. While the mandibular tuberosity on the median surface of the right mandiblewas more prominent than the left, there was equally a distortion in the alveolar alignment with deviation towards the median plane. Histologically, the right mandibular lymph node revealed moderate fibroplasia with cortical lymphoid hypoplasia and local area of mineralization with mononuclear cell infiltration (mostly macrophages) in the sinuses. These findings showed a great similarity in the mandibular morphological changes in the West African dwarf goat and other small ruminants irrespective of the causative agent. It also showed that these changes arepermanent and could lead to imbalance in the alignment of the upper and the lower jaws thereby impairing chewing and consequently, the growth of the affected and even treated animals