Protocol for a multicentre, prospective observational study of elective neck dissection for clinically node-negative oral tongue squamous cell carcinoma (END-TC study)

Introduction: In early-stage oral tongue squamous cell carcinoma (OTSCC), elective neck dissection (END) is recommended when occult lymph node metastasis is suspected; however, there is no unanimous consensus on the risks and benefits of END in such cases. The management of clinically node-negative (cN0) OTSCC remains controversial. This study, therefore, aimed to evaluate the efficacy of END and its impact on the quality of life (QoL) of patients with cN0 OTSCC. Methods and analysis: This is a prospective, multicentre, nonrandomised observational study. The choice of whether to perform END at the same time as resection of the primary tumour is based on institutional policy and patient preference. The primary endpoint of this study is 3-year overall survival. The secondary endpoint are 3-year disease-specific survival, 3-year relapse-free survival and the impact on patient QoL. Propensity score-matching analysis will be performed to reduce selection bias. Ethics and dissemination: This study was approved by the Clinical Research Review Board of the Nagasaki University. The protocol of this study was registered at the University Hospital Medical Information Network Clinical Trials Registry. The datasets generated during the current study will be available from the corresponding author on reasonable request. The results will be disseminated internationally, through scientific and professional conferences and in peer-reviewed medical journals

C/Cフクゴウザイリョウ ノ チョウコウオンカ ニオケル キョウドジンセイ

Mechanical properties of carbon fiber reinforced carbon (C/C) composites, fabricated by the preformed yarn method, were studied at elevated temperature up to 2300℃ in vacuum. Various mechanical tests including tensile, flexural, interlamina shear and fracture toughness tests were carried out to evaluate temperature dependence of strength, Young\u27s modulus and fracture toughness for three kinds of laminate C/C composites with uni-directional, 0°/90° and O°/90°/±45° fiber orientations. The failure processes of C/C composites were examined mainly focused on the influence of "transverse-cracks", which bad introduced during processing

Protocol for a multicentre, prospective observational study of elective neck dissection for clinically node-negative oral tongue squamous cell carcinoma (END-TC study)

Introduction In early-stage oral tongue squamous cell carcinoma (OTSCC), elective neck dissection (END) is recommended when occult lymph node metastasis issuspected; however, there is no unanimous consensus on the risks and benefits of END in such cases. The management of clinically node-negative (cN0) OTSCCremains controversial. This study, therefore, aimed to evaluate the efficacy of END and its impact on the quality of life (QoL) of patients with cN0 OTSCC.Methods and analysis This is a prospective, multicentre, nonrandomised observational study. The choice of whether to perform END at the same time as resection of the primary tumour is based on institutional policy and patient preference. The primary endpoint of this study is 3-year overall survival. The secondary endpoints are3-year disease-specific survival, 3-year relapse-free survival and the impact on patient QoL. Propensity score-matching analysis will be performed to reduce selection bias.Ethics and dissemination This study was approved by the Clinical Research Review Board of the Nagasaki University. The protocol of this study was registered at the University Hospital Medical Information Network Clinical Trials Registry. The datasets generated during the current study will be available from the correspondingauthor on reasonable request. The results will be disseminated internationally, through scientific and professional conferences and in peer-reviewed medical journals

The Present and Future of Materials Composition

金属系材料の複合化と性質の関係に視点をおいているが、とくに線維強化複合材料の製造法が性質を左右するので、目的製品によって製造法も考える必要がある点を強張し、具体的にいくつかのFRMについて解説した。C/Al, Sic/Al,テラノ線維/Alそしてウイスカー/金属基複合材料の製造法と性質の関係についてそれぞれ述べた。宇宙・航空そして自動車等への構造用複合材料の応用についても概説した小特集　材料複合化による新機能の創

University of Canada : A viw from Dep\u27t. of Metallurgy & Materials Science

筆者は昭和42年4月より約1年カナダ,オンタリオ州ハミルトン市McMaster Univ.のDep\u27t. of Metallurgy and Materials Scienceに出張する機会を得,この一年間の研究生活を通しその間見聞したものについてまとめた