Effect of Prefilmer Edge Thickness on Breakup Phenomena of Liquid Film in Prefilming Airblast Atomizer

[EN] This paper describes the investigation of the effect of a prefilmer edge thickness on the breakup phenomena of a liquid film in a prefilmer airblast atomizer. The breakup phenomena of the liquid film at five prefilmer edge thicknesses (160, 500, 1250, 2000, and 3000 μm) under various conditions was observed using a high-speed camera. The breakup length of the liquid film was calculated by an image processing technique developed in this study. In order to quantitatively evaluate the effect of the prefilmer edge thickness on the breakup frequency, the Fast Fourier Transformation (FFT) analysis was conducted based on the time evolution of the breakup length. The results indicated that the breakup length increase and the breakup frequency decreases by increasing prefilmer edge thickness due to a larger volume of a liquid accumulation attaching to the prefilmer edge. The FFT analysis showed that the increase in prefilmer edge thickness causes the transition of the maximal power spectrum to a lower frequency (i.e. less than 100 Hz) due to the increase in the liquid accumulation at the edge as well. Finally, a dimensionless correlation has been proposed for the breakup length of a liquid film.Okabe, T.; Katagata, N.; Sakaki, T.; Inamura, T.; Fumoto, K. (2017). Effect of Prefilmer Edge Thickness on Breakup Phenomena of Liquid Film in Prefilming Airblast Atomizer. En Ilass Europe. 28th european conference on Liquid Atomization and Spray Systems. Editorial Universitat Politècnica de València. 154-161. https://doi.org/10.4995/ILASS2017.2017.4931OCS15416

呼吸と乳房振動に伴うブラジャーカップ内の衣服圧変動

With attention to the dynamic functional property of commercially produced brassieres, this study was conducted to clarify the relationship between clothing pressure and breast vibration. The clothing pressure was measured at rest and during exercise in 11 adult females aged 21 to 26 years. Movements of the breast were visualized by stripping of the brassiere cup without deflecting its functions. The clothing pressure on the breast at rest was obviously higher under the lower half of the brassiere cup than under the upper half of the brassiere cup because of the gravitational force. They were also influenced by respiratory movement of the chest. The analysis of the relationship between clothing pressure and breast vibration during exercise revealed that the clothing pressure of the lower half of the brassiere cup increased during downward movements of the breast and decreased during upward movements of the breast

Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice

社会性の発達を調節する新たな機構を発見. 京都大学プレスリリース. 2021-03-26.Neuroligin 3 (NLGN3) and neurexins (NRXNs) constitute a canonical transsynaptic cell-adhesion pair, which has been implicated in autism. In autism spectrum disorder (ASD) development of sociality can be impaired. However, the molecular mechanism underlying NLGN3-mediated social development is unclear. Here, we identify non-canonical interactions between NLGN3 and protein tyrosine phosphatase δ (PTPδ) splice variants, competing with NRXN binding. NLGN3-PTPδ complex structure revealed a splicing-dependent interaction mode and competition mechanism between PTPδ and NRXNs. Mice carrying a NLGN3 mutation that selectively impairs NLGN3-NRXN interaction show increased sociability, whereas mice where the NLGN3-PTPδ interaction is impaired exhibit impaired social behavior and enhanced motor learning, with imbalance in excitatory/inhibitory synaptic protein expressions, as reported in the Nlgn3 R451C autism model. At neuronal level, the autism-related Nlgn3 R451C mutation causes selective impairment in the non-canonical pathway. Our findings suggest that canonical and non-canonical NLGN3 pathways compete and regulate the development of sociality

RNA-Binding Protein Musashi1 Modulates Glioma Cell Growth through the Post-Transcriptional Regulation of Notch and PI3 Kinase/Akt Signaling Pathways

Musashi1 (MSI1) is an RNA-binding protein that plays critical roles in nervous-system development and stem-cell self-renewal. Here, we examined its role in the progression of glioma. Short hairpin RNA (shRNA)-based MSI1-knock down (KD) in glioblastoma and medulloblastoma cells resulted in a significantly lower number of self renewing colony on day 30 (a 65% reduction), compared with non-silencing shRNA-treated control cells, indicative of an inhibitory effect of MSI1-KD on tumor cell growth and survival. Immunocytochemical staining of the MSI1-KD glioblastoma cells indicated that they ectopically expressed metaphase markers. In addition, a 2.2-fold increase in the number of MSI1-KD cells in the G2/M phase was observed. Thus, MSI1-KD caused the prolongation of mitosis and reduced the cell survival, although the expression of activated Caspase-3 was unaltered. We further showed that MSI1-KD glioblastoma cells xenografted into the brains of NOD/SCID mice formed tumors that were 96.6% smaller, as measured by a bioluminescence imaging system (BLI), than non-KD cells, and the host survival was longer (49.3±6.1 days vs. 33.6±3.6 days; P<0.01). These findings and other cell biological analyses suggested that the reduction of MSI1 in glioma cells prolonged the cell cycle by inducing the accumulation of Cyclin B1. Furthermore, MSI1-KD reduced the activities of the Notch and PI3 kinase-Akt signaling pathways, through the up-regulation of Numb and PTEN, respectively. Exposure of glioma cells to chemical inhibitors of these pathways reduced the number of spheres and living cells, as did MSI1-KD. These results suggest that MSI1 increases the growth and/or survival of certain types of glioma cells by promoting the activation of both Notch and PI3 kinase/Akt signaling

Resolution of inflammation: a new therapeutic frontier

Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success. However, insight into the pathways by which inflammation is resolved has highlighted novel opportunities to pharmacologically manipulate these processes — a strategy that might represent a complementary (and perhaps even superior) therapeutic approach. This Review discusses the state of the art in the biology of resolution of inflammation, highlighting the opportunities and challenges for translational research in this field

イオン液体を用いた高真空用非接触回転機構に関する研究

東京理科大学201

New Fast Algorithms for First-Order Linear Recurrences on Vector Computers

We examine the performance of parallel algorithms for first-order linear recurrence on vector computers, evaluate them quantitatively on a simple model of vector computers, and propose new fast algorithms. We also show a result of performance benchmarking of them on actual vector computers. 1 Introduction First-order linear recurrence is a basic operation often used in many algorithms of numerical analysis such as solving general block diagonal linear system. But it is also a notorious example such that we cannot get good performance on vector supercomputers. Since naive vectorization of first-order recurrence is impossible, some Japanese supercomputers have special hardware support for it. But the performance is still not so much as that for ordinary element-wise operations. On the other hand, there have been proposed many parallel algorithms for first-order recurrences [4], and some of them are tuned for vector computers [12, 14]. However, many of them cannot achieve enough perform..