Synthesis and pharmacological characterization of potent, selective, and orally bioavailable isoindoline class dipeptidyl peptidase IV inhibitors

Focused structure-activity relationships of isoindoline class DPP-IV inhibitors have led to the discovery of 4b as a highly selective, potent inhibitor of DPP-IV. In vivo studies in Wistar/ST rats showed that 4b was converted into the strongly active metabolite 4l in high yield, resulting in good in vivo efficacy for antihyperglycemic activity

学生の国際的ボランティア活動の育成を目指して : カンボジア研修報告

本学の学生が国際ボランティア活動について学ぶことができる研修制度の設立のため、我々は、2006年1月5日～1月9日、カンボジアのシェムリアップ市においてボランティア活動を継続している岡山県に本部を置くNGOを視察した。その団体の活動は、孤児・地雷障害者・母子家庭・エイズ患者の支援プロジェクト、井戸掘り・ジャックフルーツ植樹プロジェクト、および職業訓練施設(子供レストラン技能学校)の運営などである。帰国後、「新見公立短大カンボジア会」を設立して学生メンバーを募った。現在、我々は、支援物資の調達などの国内ボランティア活動、定例ワークショップの開催、開発途上国とそれらの国に係わるNGO (nongovernmental organization:非政府組織)のこと、国際協力に関する啓発・学習などを行っている。本稿では、カンボジアでの現地研修の報告と共に、今後の「新見公立短大カンボジア会」活動について検討する。We are helping students to learn International Contributions on our own college program. At the beginning of that, we visited The Kingdom of Cambodia to inspect Japanese NGO (nongovernmental organization) for 4days. We have got much experience there and learned how participants in NGO could support a mother-and-child family, orphans and mine disorders. After we came back here, we have established an activity group in our college. We report here the possibility our Cambodia study tour, various activities with our students and how we can make our students understand matters of International Contributions

開発途上国との国際交流から得た学生の学び : カンボジア・スタディツアーの教育効果

新見公立短期大学カンボジア会の活動目的は、「1.開発途上国を知り、国際的視野を身につける」「2.国際協力について考える」「3.専門職としての教養と感性を磨く」である。これらの目的を元に、学内活動およびカンボジアでの活動を行っている。そこで今回、開発途上国との国際交流が看護学生に与えた影響と教育効果を明らかにし、今後のカンボジア会活動への示唆を得ることを目的とした。結果、現地に行くことで学生が持っていたカンボジアのイメージは払拭され、アジア地域ならではの活気あふれる姿に好感を持つようになっていった。また気候や風土の違い、言語や文化の違いによる価値観の異なりを実感していた。そして専門職としての視点を持ちつつ、自分の考える国際協力を実践すること、また、東南アジア地域への関心を持ち続けることを期待できる学生の反応であった。これらのことより、カンボジア研修は活動目的を達成するものであるといえる。The missions of the Cambodia Circle of Niimi College are: 1) to understand developing countries and acquire global viewpoints, 2) to reflect on international cooperation, and 3) to refine professional intelligence and sensibilities. To achieve these goals, the circle is engaged in activities both on campus and in Cambodia. This study aimed to evaluate the impacts and educational effects of international exchanges with the country on nursing students who participated in a study tour there, and obtain suggestions for future activities of the circle. It was found that the students\u27 previously inaccurate images of Cambodia were dispelled by visiting the country, becoming attracted by active lifestyles characteristic of certain Asian nations. They also became aware of the diversity in values stemming from differences in the climate, language, and culture between both countries. Furthermore, they behaved in a way we would expect of them to practice their own global cooperation from a professional viewpoint, and maintain their interest in Southeast Asia. These observations indicate that the study tour in Cambodia fulfills the circle\u27s missions

平成19年度特色ある大学教育支援プログラムに選定 質の高い看護職養成のための看護研究 : 主体的課題発見能力を育てる学習支援

平成19年度特色ある大学教育支援プログラムの「教育方法の工夫改善を主とする取組」に応募したところ、全国から331件の応募があり、本取組が審査によって選定された。短期大学士課程では、70件中12件のみ選定された。そこで、看護学科全員で取組んでいる看護研究について申請内容を中心に報告する。We applied for Support Program for Distinctive University Education in the category of improvement of teaching methods in 2007, and was selected as one of the "Good Practice (GP)" out of 331 programs nationwide. Only 12 programs were chosen out of 70 applicants in the junior college division. This is a report of the application about the nursing research in which all the faculty members of the Department of Nursing have been engage

Genetic relatedness between Japanese and European isolates of Clostridium difficile originating from piglets and their risk associated with human health

Clostridium difficile colonization in pig intestine has been a public health concern. We analyzed C. difficile prevalence among piglets in Japan to clarify their origin and extent of the associated risk by using molecular and microbiological methods for both swine and human clinical isolates and foreign isolates. C. difficile was isolated from 120 neonatal piglet fecal samples. Toxin gene profile, antimicrobial susceptibilities, PCR ribotype, and multiple-locus variable-number tandem-repeat analysis (MLVA) type of swine isolates were determined and compared with those of human clinical and foreign isolates. One-hundred C. difficile strains were isolated from 69 (57.5%) samples, and 61 isolates (61%) were toxin gene-positive. Some isolates were resistant to antimicrobials, contributing to antibiotic-associated diarrhea by C. difficile. These results suggest that C. difficile, prevalent among Japanese pigs, is a potential risk for antibiotic-associated diarrhea. Furthermore, PCR ribotype 078 (12 isolates), which has been linked to multiple outbreaks worldwide, was the third-most frequently isolated of the 14 PCR ribotypes identified. Moreover, MLVA revealed that all 12 PCR ribotype 078 isolates were genetically related to European PCR ribotype 078 strains found in both humans and pigs. To date, in Japan, many breeding pigs have been imported from European countries. The genetic relatedness of C. difficile isolates of Japanese swine origin to those of European origin suggests that they were introduced into Japan via imported pigs