オグラ シンリョウショ トクシマシ ニオケル セイカンセンショウ ノ ゲンキョウ

A survey on sexually transmitted diseases was conducted in Ogura Shinryosho Clinic in Tokushima city in Japan from April２０００through March２００５． １．A total number of 2,170 outpatients（7-89,mean 34.6 years）visited during the 5 years. Men were over 8.4 times compared to women. ２．The number of patients was least in 2001. ３．According to the seasons, the number of patients in summer time was highest. ４．Considering the age, patients in there 20’ s were the highest while senior patients were tended to decrease. ５．Infection rates of genital chlamydia, gonococcal infection, syphilis and genital herpes were 15.9%, 5.3%, 2.8% and 23.5%, respectively. The double infection rate was 5.3% and the triple infection rate was 0.3%. ６．Chlamydial infection rate was 29.1% in 2000, 12.3% in 2001, 13.9% in 2002, 11.4% in 2003 and 12.7% in 2004. Chlamydial infection rate reduced to about 50% but gonococcal infection gradually increased year by year. The gonococcal infection rates were 1.4% in 2000, 6.0% in 2001, 5.6% in 2002, 7.2% in 2003 and 6.1% in 2004. Incidence of syphilis was low and stable throughout the 5 years. Infection rates of genital herpes were 6.0% in 2000, 12.7% in 2001, 21.7% in 2002, 33.8% in 2003 and 37.2% in 2004

オグラ シンリョウジョ トクシマシ ニ オケル ダンシ ニョウドウエン ノ チリョウ セイセキ

I reviewed on 112 patients with gonococcal urethritis and 292 patients with chlamydial urethritis consulted on the Ogura Shinryosho Clinic in Tokushima between April, 2000 and March, 2005. Intravenous injection of 1g Ceftriaxone sodium for one day and 400mg Cefpodoxime proxetil for seven days were administered to the case which the gonococcal infection was suspected from examining in an interview and a urinalysis. Four hundred mg Gatifloxacin hydrate or 400 mg Clarithromycin for seven days was administered to the patient whom non-gonococcal infection was suspected. After confirmed diagnosis, I administered 200 mg Minocycline hydrochloride for more seven days. Seven to fourteen days after the medication, I evaluated the effectiveness by the polymerase chain reaction method using the semen specimen material that was able to inspect the presence of the male accessory gland infections at the same time. The recovery rate of the gonococcal urethritis was 91.8%, and chlamydial urethritis was 64.1%. Two patients of 112 （1.8%） in the gonococcal urethritis, and 94 patients of 292 （32.2%） in chlamydial urethritis were withdrawn on the way of treatment. The recovery rate and the treatment completion rate of chlamydial urethritis were low because symptoms of chlamydial urethritis were mild or none

バイアグラ イッパンメイ クエンサン シルデナフィル ノ シヨウ ケイケン ト ゼンゴ ケンキュウ ニヨル コウカ ヒョウカ : ダイ1ペン ライインシャ ノ トクチョウ

Since Sildenafil became available in Japan five years ago, 208 outpatients with Erectile Dysfunction（ED）have consulted the Ogura Shinryosho Clinic in Tokushima City, Japan. On August 31st 1999, an article in the Tokushima Newspaper warned readers of the possible side effects of Sildenafil including heart attacks. After the publication of this article, the number of patients in this clinic dropped by 80%. The mean age of the patients in this study was 57.2 with a distribution between 29 and 84. The morbidity period of ED is 35 months, and it is described as decreasing logarithmically ; only 22 outpatients in this study experienced symptoms occurring over six years. Several patients in this study experienced past medical problems including Diabetes Mellitus（18.3%）, heart disease（14.5%）, and benign prostatic hyperplasia（12.4%）. Pigmentary retinal degeneration（PRD）is classified as one of Sildenafil’s contraindications. Although no patients experienced PRD in this study, over 50 male patients in the prefecture of Tokushima have been diagnosed with PRD. It should be noted that there are possible complications associated with taking Sildenafil before the onset of PRD and Usher Syndrome

バイアグラ イッパンメイ クエンサン シルデナフィル ノ シヨウ ケイケン ト ゼンゴ ケンキュウ ニヨル コウカ ヒョウカ : ダイ2ヘン バイアグラ ノ リンショウ コウカ ト セイコウ ノ マンゾク ノ コウゾウ ニツイテ

A total of 145 cases with Erectile Dysfunction（ED）have been evaluated by the Ogura Shinryosho Clinic in Tokushima City, Japan. The effectiveness of Sildenafil, defined here as intercourse satisfaction（V）, was quantified through a pre-treatment and a post-treatment self-report measurement called the IIEF 5 Questionnaire. The structural components that contribute to intercourse satisfaction（V）were also evaluated. Confidence（I），ability to penetrate（Ⅱ）, frequency of intercourse（Ⅲ），and maintenance of an erection（Ⅳ）were predicted to contribute to intercourse satisfaction. Results of this study show that 52.4% of the patients（n=145）achieved a normal level of intercourse satisfaction（indicated by a score of 22-25 on the IIEF 5）. The patients’collective score improved from 9.84 to 20.63 on the IIEF 5 and was statistically significant（p<0.000）. Numbers needed to treat（NNT）was found to be 2 patients. The structural components found to contribute to intercourse satisfaction（V）through multiple linear regressions were frequency of intercourse（Ⅲ）, maintenance of an erection（Ⅳ）, and ability to penetrate（Ⅱ）. Confidence（I）did not contribute to intercourse satisfaction（V）. No severe adverse events to Sildenafil were observed, but some minor side effects included flushing（4.14%）, headaches（2.07%）, heart palpitation（0.69%）, and dyspepsia（0.69%）

Impact of Native Coronary Artery Calcification on Lesion Outcome Following Drug-Coated Balloon Angioplasty for Treatment of In-Stent Restenosis

This study aimed to clarify whether native coronary artery（CA） calcification before index percutaneous coronary intervention（PCI） has an impact on the effectiveness of drug-coated balloon（DCB） angioplasty for the treatment of in-stent restenosis（ISR）. 100consecutive patients with 166ISR lesions underwent quantitative coronary angiography（QCA） before and after index PCI and before and after DCB angioplasty for ISR. CA calcification before index PCI was assessed by angiography and results were analyzed to reveal the predictive values for target lesion revascularization（TLR） and major adverse cardiac events（MACE）. During 1.03±1.03years of follow-up, TLR occurred in 44lesions（26.5%） and MACE in 33 patients（33%）. On multivariate analysis, CA calcification before index PCI（p=0.016）, and % diameter of stenosis（%DS）≥73%（p=0.023） and minimal lumen diameter（MLD）<0.65mm（p=0.001） before DCB angioplasty were independent predictors for TLR after DCB angioplasty. MACE was also associated with CA calcification before index PCI（p=0.01）, and %DS≥73%（p=0.001） and MLD<0.65mm（p=0.01） before DCB angioplasty, but only %DS≥73% before DCB angioplasty was an independent predictor for MACE after DCB angioplasty（p=0.039）. The combination of CA calcification before index PCI and these QCA factors before DCB angioplasty was an independent and more powerful predictor for MACE than the QCA factors alone（p<0.001）. Thereafter, the combination of CA calcification and %DS≥73% before DCB angioplasty stratified the risk of MACE after DCB angioplasty（p<0.05）. CA calcification before index PCI, as well as anatomical information at ISR, have an impact on outcome after DCB angioplasty for ISR

Laser-driven multi-MeV high-purity proton acceleration via anisotropic ambipolar expansion of micron-scale hydrogen clusters

強力なレーザーを使ってエネルギーがそろった純度100％の陽子ビーム発生に成功 --レーザー駆動陽子ビーム加速器の実現へ向けて大きく前進--. 京都大学プレスリリース. 2022-10-13.Multi-MeV high-purity proton acceleration by using a hydrogen cluster target irradiated with repetitive, relativistic intensity laser pulses has been demonstrated. Statistical analysis of hundreds of data sets highlights the existence of markedly high energy protons produced from the laser-irradiated clusters with micron-scale diameters. The spatial distribution of the accelerated protons is found to be anisotropic, where the higher energy protons are preferentially accelerated along the laser propagation direction due to the relativistic effect. These features are supported by three-dimensional (3D) particle-in-cell (PIC) simulations, which show that directional, higher energy protons are generated via the anisotropic ambipolar expansion of the micron-scale clusters. The number of protons accelerating along the laser propagation direction is found to be as high as 1.6 ±0.3 × 10⁹/MeV/sr/shot with an energy of 2.8 ±1.9 MeV, indicating that laser-driven proton acceleration using the micron-scale hydrogen clusters is promising as a compact, repetitive, multi-MeV high-purity proton source for various applications

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

Background and purposeThe Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 and published in the Journal of JSICM, [2017; Volume 24 (supplement 2)] https://doi.org/10.3918/jsicm.24S0001 and Journal of Japanese Association for Acute Medicine [2017; Volume 28, (supplement 1)] http://onlinelibrary.wiley.com/doi/10.1002/jja2.2017.28.issue-S1/issuetoc.This abridged English edition of the J-SSCG 2016 was produced with permission from the Japanese Association of Acute Medicine and the Japanese Society for Intensive Care Medicine.MethodsMembers of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ) and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two-thirds (> 66.6%) majority vote of each of the 19 committee members.ResultsA total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J-SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation, and its supporting evidence were also added to each recommendation statement. We conducted meta-analyses for 29 CQs. Thirty-seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for five CQs.ConclusionsBased on the evidence gathered, we were able to formulate Japanese-specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non-specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection