Diagnostic challenges and psychosocial impacts of hypersomnia in a Nigerian adolescent: A case report

Hypersomnia, a disorder of sleep characterized by excessive quantity of sleep and excessive daytime sleepiness (EDS), could adversely affect health outcomes in childhood. To highlight diagnostic challenges and the impact of childhood hypersomnia in a resource limited setting, a 14year old Nigerian who presented with a seven year history of hypersomnia was studied. Screening for sleep disorder using BEARS sleep algorithm and assessment for EDS using the Epworth Sleepiness Scale were both positivefor EDS. The assessment of sleep hygiene using the Adolescent Sleep Hygiene Scale was normal and the use of Raven’s Progressive Matrices to assess intelligence was also normal. There was no contributory pastmedical history or demonstrable etiology. Magnetic Resonance Imaging (MRI) of the brain, Electro Encephalogram (EEG), assay of serum electrolytes were all normal while screening test for trypanosomiasis was negative. Poor level of awareness, high cost of evaluation and limited facilities for diagnosis of sleep disorder were the major diagnostic challenges. Depression, poor academic performance, suicidal ideation andstigmatization were all associated with hypersomnia in the patient.Keywords: Hypersomnia, adolescence, depression, sleep disorders, diagnostic challenges

In Vivo Anti-Trypanosomal Activity of Ethanolic Leaf Extract of Carissa Spinarum (Wild Karanda) in Mice Infected with Trypanosoma Brucei Brucei Spp.

Carissa Spinarum plant has been implicated as a medicinal plant for joints, muscle, chest pains by the massai people of Kenya, also as an antiviral supplement for HIV treatment in Tanzania. Acute toxicity of the ethanolic leaf extract and minimum inhibition concentration (MIC) using four (4) microorganism (proteus, e.coli, staphylococcus aureus spp & enterobacter spp) was evaluated in mice using Lorke’s method & serial dilution method respectively. The ethanolic leaf extract was evaluated for in vivo anti-trypanosomal activity against federa strain of Trypanosoma brucei brucei in albino mice. Four days suppressive, curative effect against established infection and prophylactic models of anti-trypanosomal studies were carried out. The median lethal dose of the extract was determined to be ? 100mg ? kg body weight. The extract (12.5, 25, 50mg / kg) exerted some dose dependent suppressive effects at the different levels of infections tested, with no significant curative effects recorded. However, further antitrypanosomal property can be explored for the management of trypanosomiasis. Keywords: Carissa spinarum, antitrypanosomal, albino mice, trypanosome brucei brucei speci

The Prevalence Of Trypanosome Infection In Trade Cattle, Goats And Sheep Slaughtered At The Kaduna Abattoir

The prevalence of trypanosome infection in trade cattle, goats and sheep was investigated in slaughtered animals at the Kaduna Abattoir. Wet, thin, thick films, animal inoculation, haematocrit centrifugation technique and buffy coat methods were used to detect rypanosomes in the jugular blood of the animals. The packed cell volume (PCV) was also determined. A total of 300 cattle, 300 goats and 300 sheep were examined within five months (September, 1998 – January, 1999) and the prevalence rates in cattle, goats and sheep were found to be 5.00%, 4.67% and 3.33% respectively. Mean PCV of infected cattle was 20.33% against uninfected cattle 35.08%. In goats, the PCV was 20.29%, uninfected goats 31.56%; while that of sheep was 19.40% and uninfected 32.85%. Trypanosoma vivax infection accounted for 60%, T. brucei 26.67% and T. congolense 13.33% in cattle. In goats, T. vivax infection accounted for 71.43%, T. brucei 21.43% and T. congolense 7.14%. Also T. vivax infection accounted for 70%, T. brucei 30% and T. congolense 0% in sheep. Sex did not significantly (P>0.05) affect infection rates. Although the prevalence rate of trypanosomiasis in cattle, goats and sheep appeared low compared with the previous works, natural trypanosomiasis remains economically importance in cattle, goats and sheep in Nigeria.African Journal of Clinical and Experimental Microbiology Vol. 10 (1) 2009: pp. 15-2

Effect of trypanosoma congolense and Trypanosoma brucei mixed infection on the pattern of haematological changes in murine trypanosmosis

The effect of Trypanosoma congolense and T. brucei mixed infection on the pattern of haematological changes was demonstrated in a rat model. At the end of 21 days post infection (PI), anaemia which was characterised by drop in the packed cell volume (PCV), was found to be significantly (