Performance of the TPC with Micro Pixel Chamber Readout: micro-TPC

Micro-TPC, a time projection chamber(TPC) with micro pixel chamber($\mu$-PIC) readout was developed for the detection of the three-dimensional fine(sub-m illimeter) tracks of charged particles. We developed a two-dimensional position sensitive gaseous detector, or the $\mu$-PIC, with the detection area of 10$\times$10 cm${}^{2}$ and 65536 anode electrodes of 400 $\mu$m pitch. We achieved the gas gain of over 10000 without any other multipliers. With the pipe-line readout system specially developed for the $\mu$-PIC, we detected X-rays at the rate as high as 7.7 Mcps. We attached a drift cage with an 8 cm drift length to the $\mu$-PIC and developed a micro-TPC. We measured the basic performances of the micro-TPC and took three-dimensional tracks of electrons. We also developed a prototype of the MeV gamma-ray imaging detector which is a hybrid of the micro-TPC and NaI(Tl) scintillators and confirmed its concept by reconstructing the obtained data.Comment: 6 pages 16 figures, submitted for IEEE/TNS 200

Performance of large area Micro Pixel Chamber

A novel gaseous two-dimensional imaging detector "Micro Pixel Chamber (micro-PIC)" has been developed. This detector is based on double sided printed circuit board (PCB). We have developed large area (10cm x 10cm) micro-PICs with 65536 pixel anodes of 400um pitch on a 100um thick insulating substrate. Achieved energy resolution was 30% (FWHM) at 5.9keV, and a gas gain of 7000 was obtained with argon ethane (8:2) gas mixture. This gain is high enough to detect minimum ionizing particles with such a small electrode pitch. Although several discharges occurred during 65 hours continuous operation, the detectors have kept stable operation with high gain. The micro-PIC is a useful detector for many applications e.g. X-ray, gamma ray, and charged particle imaging. The micro electrode structure allows us to measure directions of primary electrons due to incident X-rays or gamma rays, which provide a strong method for X-ray polarimetry and gamma-ray imaging.Comment: 4 pages, 8 figures, to appear in the proceedings of 6th International Conference on Position Sensitive Detectors, 9-13 Sep 2002, Leicester, UK (Nucl. Instr. and Meth. A

Performance of a micro-TPC for a time-resolved neutron PSD

We report on the performance of a micro-TPC with a micro pixel chamber($\mu$-PIC) readout for a time-resolved neutron position-sensitive detector(PSD). Three-dimensional tracks and the Bragg curves of protons with energies of around 1 MeV were clearly detected by the micro-TPC. More than 95% of gamma-rays of 511 keV were found to be discriminated by simple analysis. Simulation studies showed that the total track length of proton and triton emitted from the $\rm {}^{3}He$(n,p(573 keV))$\rm {}^{3}H(191 keV)$ reaction is about 1.2 cm, and that both particles have large energy losses ($\rm > 200 keV/cm$) in 1 atm Ar+$\rm C_{2}H_{6}(10$+${}^{3}$He($< 1$). These values suit the current performance of the micro-TPC, and we conclude that a time-resolved neutron PSD with spatial resolution of sub-millimeters shall be developed as an application of the micro-TPC.Comment: 13 pages, 10 figures, to appear in NIM

Development of a low-alpha-emitting {\mu}-PIC for NEWAGE direction-sensitive dark-matter search

NEWAGE is a direction-sensitive dark-matter-search experiment that uses a micro-patterned gaseous detector, or {\mu}-PIC, as the readout. The main background sources are {\alpha}-rays from radioactive contaminants in the {\mu}-PIC. We have therefore developed a low-alpha-emitting {\mu}-PICs and measured its performances. We measured the surface {\alpha}-ray emission rate of the {\mu}-PIC in the Kamioka mine using a surface {\alpha}-ray counter based on a micro TPC.Comment: 6 pages, 4 figure

Study of Negative-Ion TPC Using {\mu}-PIC for Directional Dark Matter Search

Negative-ion time projection chambers(TPCs) have been studied for low-rate and high-resolution applications such as dark matter search experiments. Recently, a full volume fiducialization in a self-triggering TPC was realized. This innovative technology demonstrated a significant reduction in the background with MWPC-TPCs. We studied negative-ion TPC using the {\mu}-PIC+GEM system and obtained sufficient gas gain with CS$_{2}$gas and SF$_{6}$ gas at low pressures. We expect an improvement in detector sensitivity and angular resolution with better electronics

Development of a time projection chamber with micro pixel electrodes

A time projection chamber (TPC) based on a gaseous chamber with micro pixel electrodes (micro-PIC) has been developed for measuring three-dimensional tracks of charged particles. The micro-PIC with a detection area of 10 cm square consists of a double-sided printing circuit board. Anode pixels are formed with 0.4 mm pitch on strips aligned perpendicular to the cathode strips in order to obtain a two-dimensional position. In the TPC with drift length of 8 cm, 4 mm wide field cage electrodes are aligned at 1mm spaces and a uniform electric field of about 0.4 kV/cm is produced. For encoding of the three-dimensional position a synchronous readout system has been developed using Field Programmable Gate Arrays with 40 MHz clock. This system enables us to reconstruct the three-dimensional track of the particle at successive points like a cloud chamber even at high event rate. The drift velocity of electrons in the TPC was measured with the tracks of cosmic muons for three days, during which the TPC worked stably with the gas gain of 3000. With a radioisotope of gamma-ray source the three-dimensional track of a Compton scattered electron was taken successfully.Comment: 4 pages, 7 figures, to appear in the proceedings of 6th International Conference on Position Sensitive Detectors, 9-13 Sep 2002, Leicester, UK (Nucl. Instr. and Meth. A

Simulation study of electron drift and gas multiplication in Micro Pixel Chamber

The physical processes of charge collection and gas multiplication of a Micro Pixel Chamber (mu-PIC) were studied in detail using a three-dimensional simulation. The collection efficiencies of primary electrons and gas multiplication factors were calculated for several electrode structures. Based on those studies, we analyzed the optimization of the electrode structure of the mu-PIC, in order to obtain a high gas gain of more than 10^4 and a simultaneous suppression of discharges. Consequently, we found that these characteristics strongly depend on the substrate thickness and the anode diameter of the mu-PIC. In addition, a gas gain of 10^5 would be expected for a mu-PIC having a thick substrate of > 150um.Comment: 16 pages, 14 figures, Submitted to Nucl. Instr. Methods

Detecting the WIMP-wind via spin-dependent interactions

Revealing the nature of dark matter is one of the most interesting tasks in astrophysics. Measuring the distribution of recoil angles is said to be one of the most reliable methods to detect a positive signature of dark matter. We focused on measurements via spin-dependent interactions, and studied the feasibility with carbon tetrafluoride($\rm CF_4$) gas, while taking into account the performance of an existing three-dimensional tracking detector. We consequently found that it is highly possible to detect a positive signature of dark matter via spin-dependent interactions.Comment: 14 pages, 5 figures, submitted for Physics Letters

ABCA7 Gene Expression and Genetic Association Study in Schizophrenia

Introduction: Although ATP-binding cassette sub-family A member 7 gene (ABCA7) is known to be associated with Alzheimer’s disease, the relationship between ABCA7 and schizophrenia has been unknown. Methods: Schizophrenia patients (n = 50; 24 males, 62.1 ± 0.50 years old) and age- and sex-matched healthy controls (n = 50) were recruited for the mRNA analysis. Additionally, a case-control study for the rs3764650 genotypes was performed with 1308 samples (control subjects; n = 527, schizophrenia patients; n = 781). All participants were Japanese, unrelated to each other, and living in the same area. Results: The distributions of the rs3764650 genotypes in schizophrenia patients were not different from that of controls. However, the ABCA7 mRNA expression levels in schizophrenia patients were significantly higher than those in controls by a logistic regression analysis. Additionally, the ABCA7 mRNA expression levels in schizophrenia patients were correlated with the rs3764650 genotypes in a dose-dependent manner. Discussion: The ABCA7 mRNA expression levels in peripheral blood with the rs3764650 genotypes may be related to pathological mechanisms in schizophrenia and may be a biological marker for schizophrenia