5 research outputs found
Performance of Mechanical Filters and Respirators for Capturing Nanoparticles ―Limitations and Future Direction
CompNanoTox2015: novel perspectives from a European conference on computational nanotoxicology on predictive nanotoxicology
A first European Conference on Computational Nanotoxicology, CompNanoTox, was held in November 2015 in Benahavís, Spain with the objectives to disseminate and integrate results from the European modeling and database projects (NanoPUZZLES, ModENPTox, PreNanoTox, MembraneNanoPart, MODERN, eNanoMapper and EU COST TD1204 MODENA) as well as to create synergies within the European NanoSafety Cluster. This conference was supported by the COST Action TD1204 MODENA on developing computational methods for toxicological risk assessment of engineered nanoparticles and provided a unique opportunity for cross fertilization among complementary disciplines. The efforts to develop and validate computational models crucially depend on high quality experimental data and relevant assays which will be the basis to identify relevant descriptors. The ambitious overarching goal of this conference was to promote predictive nanotoxicology, which can only be achieved by a close collaboration between the computational scientists (e.g. database experts, modeling experts for structure, (eco) toxicological effects, performance and interaction of nanomaterials) and experimentalists from different areas (in particular toxicologists, biologists, chemists and material scientists, among others). The main outcome and new perspectives of this conference are summarized here.status: publishe
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Correlation Between Physicochemical Characteristics and Toxicological Properties of Nanomaterials
Abstract : Research Summaries: Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles; Translocation of inhaled ultrafine manganese oxide particles to the central nervous system; Nanoparticle (NP) uptake by type I alveolar epithelial cells and their oxidant stress response; Toxicology of nanoparticles: A historical perspective; In vivo skin penetration of quantum dot nanoparticles in the murine model: The effect of UVR; Testing nanomaterials of unknown toxicity: An example based on Platinum nanoparticles of different shapes; Nanoparticles and the Brain: Cause for Concern?; Concept of assessing nanoparticle hazards considering nano-particle dosemetric and chemical/biological response-metrics; Validation of an LDH assay for assessing nanoparticle toxicity; Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology