EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369

Historia de la vida, milagros y virtudes del glorioso San Luis Bertran, del orden de predicadores [Texto impreso]

Sign. : [calderón]8, 2[calderón]2, A-Y8, Z4Port. con esc. xil. de los DominicosErrores tipográficos en la pag.Texto a dos col

La Venerable Madre Sor María Vilani, Religiosa de la Orden de Santo Domingo... : compendio de su prodigiosa vida y virtudes

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Historiadores de Indias

Texto a dos colContiene: T. I. Apologética historia de las Indias de Fr. Bartolomé de las Casas, 704 p., T. II. Guerra de Quito de Pedro de Cieza de León, Jornada del río Marañon de Toribio de Ortiguera, Jornada de Omagua y Dorado, Descripción del Perú, Tucumán, Río de la Plata y Chile de Fr. Reginaldo de Lizárraga, 678 p

Theologia Divi Thomae frustillatim in theses comminuta ...

Copia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 2016Fecha en el tít.: 1762Sign.: *-**2, A-Z2, Aa-Ss2Port. con viñeta xil.H. de grab. calc. a continuación de port.: "Paschasius Moles Sculpt. Valª. 1762", retrato de Pedro de Albornoz Tapies, obispo de OrihuelaGrab. calc. en cabecera de p. 1 : "Se hallarà en la Imprenta de Joseph Thomàs Lucas. Ballester Sc.

Spectrograph dedicated to measuring tropospheric trace gas constituents from space

Several organizations in the Netherlands are cooperating to develop user requirements and instrument concepts in the line of SCIAMACHY and OMI but with an increased focus on measuring tropospheric constituents from space. The concepts use passive spectroscopy in dedicated wavelength sections in the range of 300 to 2400 nm and wide angle, non-scanning, swath viewing. To be able to penetrate into the troposphere small ground pixels are used to obtain a fair fraction of cloud-free pixels and to allow precise detection of the sources of polluting gases. The trace gas products aimed for are O3, NO 2, HCHO, H2O, SO2, Aerosol (optical depth, type and absorption index), CO and CH4, covering science Issues on air quality and climate. The main challenge in the instrument design is to obtain a good signal-to-noise for cloud free pixels and for low ground albedo and light levels. Also the retrieval of separated tropospheric and stratospheric column amounts from a nadir looking instrument is challenging. The paper discusses the user requirements and compares alternative measurement strategies. It explains the selection of passive UV-Visible-NIR spectroscopy and comes with an instrument concept which provides the current best realisation of the user requirements