Surgical decompression for endocrine ophthalmopathy: state-of-the-art

A.A.&nbsp;Krylova, O.I.&nbsp;Krivosheina Siberian State Medical University, Tomsk, Russian Federation The article addresses historical overview of surgical techniques for orbital decompression in patients with endocrine ophthalmopathy over the last century. The authors discuss available surgical approaches and techniques for orbital decompression, indications, and potential complications. Surgical techniques for endocrine ophthalmopathy include bony orbitotomy and internal orbital decompression which usually involves the resection of periocular fat. Currently, transpalpebral, transconjunctival, and endonasal approaches are used to reach orbit and its walls. Surgical volume of orbital wall resection depends on exophthalmos severity. Partial resection of internal and inferior orbital walls is less traumatic procedure. However, analysis of the efficacy of available techniques for orbital decompression for endocrine ophthalmopathy demonstrates that exophthalmos significantly improves after the resection of two or more orbital walls only. Considering this, trans-ethmoidal endonasal orbital decompression with the resection of medial and inferior orbital walls characterized by minimal invasiveness, lack of skin incisions and surgical scars is the first choice. The choice of surgical strategy and surgical volume in endocrine ophthalmopathy depends on the s everity of clinical manifestations, expected clinical functional outcomes, and risks of potentional complications. Keywords: endocrine ophthalmopathy, edematous exophthalmos, orbital decompression, external orbitotomy, trans-ethmoidal endonasal orbital decompression, internal orbital decompression. For citation: Krylova A.A., Krivosheina O.I. Surgical decompression for endocrine ophthalmopathy: state-of-the-art. Russian Journal of Clinical Ophthalmology. 2019;19(3):154–158. About the authors: Anna&nbsp;A.&nbsp;Krylova — MD, PhD, Assistant of the Department of Ophthalmology, ORCID iD 0000-0001-8009-6302; Olga&nbsp;I.&nbsp;Krivosheina — MD, PhD, Professor, Head of the Department of Ophthalmology, ORCID iD 0000-0001-7509-5858. Siberian State Medical University. 2, Moscow tract, Tomsk, 634050, Russian Federation. Contact information:&nbsp;Anna&nbsp;A.&nbsp;Krylova, e-mail:&nbsp;[email protected].&nbsp;Financial Disclosure:&nbsp;no authors have a financial or property interest in any material or method mentioned. There is no&nbsp;conflict of interests. Received&nbsp;22.02.2019. </p

Perspectives of proteomic analysis in ophthalmology

A.A. Krylova1, A.V. Zakharchuk1, O.I. Krivosheina1, S.I. Pekov2,3, I.A. Popov1,3 1Siberian State Medical University, Tomsk, Russian Federation 2Skolkovo Institute of Science and Technologies, Skolkovo, Russian Federation 3Moscow Institute of Physics and Technology, Moscow, Russian Federation This paper reviews the perspectives of proteomic analysis of tear and aqueous humor to determine biomarkers for the differential diagnosis of eye disorders. The methodology of sample collection and the advantages and disadvantages of the available methods are discussed in detail. The results of proteomic mapping of tear and aqueous humor in dry eye disease, keratoconus, glaucoma, cataract, age-related macular degeneration, and diabetic retinopathy are described. The association between the levels of identified proteins and their role in triggering pathological processes, e.g., oxidative stress with autophagy (and, as a result, tissue dystrophy), initiation of inflammation, and impairment of metabolic processes at the molecular level with activation of pathological proteolysis (that ultimately lead to cellular and tissue changes with the development of the above-mentioned diseases) are of particular importance. This paper also emphasizes the practical relevance of using proteomics to study the pathogenesis of eye diseases, which implies determining the association between genotype and phenotype of a patient in clinical practice with further treatment personalization. Proteomics also provides an early noninvasive diagnosis of socially significant eye diseases. Keywords: proteomic analysis, tear, aqueous humor, mass spectrometry, eye disorders. For citation: Krylova A.A., Zakharchuk A.V., Krivosheina O.I., Pekov S.I., Popov I.A. Perspectives of proteomic analysis in ophthalmology. Russian Journal of Clinical Ophthalmology. 2023;23(4):213–218 (in Russ.). DOI: 10.32364/2311-7729-2023-23-4-7. </p

Quinone regulation of mitochondria functional activity

Comparative study of quinones influence on mitochondrial respiration activity and mem­brane potential changes have been carried out