8 research outputs found
Indicators of the osteoclastogenesis system in men with different clinical types of ankylosing spondylitis
Objective: to evaluate the osteoclastogenesis regulatory system β osteoprotegerin/receptor activator of nuclear factor-ΞΊΞ² ligand (OPG/RANKL)Β system β in men with different clinical types of ankylosing spondylitis (AS).Subjects and methods. The osteoclastogenesis regulatory system was studied in 60 men, including 40 patients diagnosed with AS complying withΒ the 1984 New York criteria and 20 men without AS. RANKL, a major stimulant of osteoclastogenesis, and OPG, a decoy receptor that bindsΒ RANKL and, accordingly, blocks osteoclastogenesis, were investigated.Results. It was shown that in the patients with AS, RANKL concentrations were normal and the content of OPG and OPG/RANKL ratio provedΒ to be significantly higher than those in the men without AS. The highest OPG concentrations were recorded in patients with the axial form of thisΒ disease, its moderate activity and early X-ray stage. No relationship was found between the level of RANKL and the clinical characteristics ofΒ AS; however, there was a tendency to a slight increase in its concentration in patients with extraskeletal manifestations of AS, its high activity,Β high functional class, and late X-ray stage.Conclusion. The considerable increase in OPG levels and OPG/RANKL ratio was ascertained to be associated to the fact that 94% of theΒ patients with late-stage AS characterized by the presence of numerous syndesmophytes. These changes must be compensatory in response toΒ modestly increased RANKL level and enhanced bone resorption
ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΠΈΡΡΠ΅ΠΌΡ ΠΎΡΡΠ΅ΠΎΠΊΠ»Π°ΡΡΠΎΠ³Π΅Π½Π΅Π·Π° Ρ ΠΌΡΠΆΡΠΈΠ½ Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π²Π°ΡΠΈΠ°Π½ΡΠ°ΠΌΠΈ Π°Π½ΠΊΠΈΠ»ΠΎΠ·ΠΈΡΡΡΡΠ΅Π³ΠΎ ΡΠΏΠΎΠ½Π΄ΠΈΠ»ΠΈΡΠ°
Objective: to evaluate the osteoclastogenesis regulatory system β osteoprotegerin/receptor activator of nuclear factor-ΞΊΞ² ligand (OPG/RANKL)Β system β in men with different clinical types of ankylosing spondylitis (AS).Subjects and methods. The osteoclastogenesis regulatory system was studied in 60 men, including 40 patients diagnosed with AS complying withΒ the 1984 New York criteria and 20 men without AS. RANKL, a major stimulant of osteoclastogenesis, and OPG, a decoy receptor that bindsΒ RANKL and, accordingly, blocks osteoclastogenesis, were investigated.Results. It was shown that in the patients with AS, RANKL concentrations were normal and the content of OPG and OPG/RANKL ratio provedΒ to be significantly higher than those in the men without AS. The highest OPG concentrations were recorded in patients with the axial form of thisΒ disease, its moderate activity and early X-ray stage. No relationship was found between the level of RANKL and the clinical characteristics ofΒ AS; however, there was a tendency to a slight increase in its concentration in patients with extraskeletal manifestations of AS, its high activity,Β high functional class, and late X-ray stage.Conclusion. The considerable increase in OPG levels and OPG/RANKL ratio was ascertained to be associated to the fact that 94% of theΒ patients with late-stage AS characterized by the presence of numerous syndesmophytes. These changes must be compensatory in response toΒ modestly increased RANKL level and enhanced bone resorption.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΎΡΠ΅Π½ΠΈΡΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΠΎΡΡΠ΅ΠΎΠΊΠ»Π°ΡΡΠΎΠ³Π΅Π½Π΅Π·Π° β ΠΎΡΡΠ΅ΠΎΠΏΡΠΎΡΠ΅Π³Π΅ΡΠΈΠ½/Π»ΠΈΠ³Π°Π½Π΄ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° Π°ΠΊΡΠΈΠ²Π°ΡΠΎΡΠ°Β Π½ΡΠΊΠ»Π΅Π°ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° ΞΊΞ² (OPG/RANKL) β Ρ ΠΌΡΠΆΡΠΈΠ½ Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π²Π°ΡΠΈΠ°Π½ΡΠ°ΠΌΠΈ Π°Π½ΠΊΠΈΠ»ΠΎΠ·ΠΈΡΡΡΡΠ΅Π³ΠΎ ΡΠΏΠΎΠ½Π΄ΠΈΠ»ΠΈΡΠ° (ΠΠ‘).ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π‘ΠΈΡΡΠ΅ΠΌΠ° ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΠΎΡΡΠ΅ΠΎΠΊΠ»Π°ΡΡΠΎΠ³Π΅Π½Π΅Π·Π° ΠΈΠ·ΡΡΠ°Π»Π°ΡΡ Ρ 60 ΠΌΡΠΆΡΠΈΠ½: 40 Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ ΠΠ‘, ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΠΌ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΡΡ-ΠΠΎΡΠΊΡΠΊΠΈΠΌ ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌ (1984 Π³.) ΠΈ 20 ΠΌΡΠΆΡΠΈΠ½ Π±Π΅Π· ΠΠ‘. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ RANKL β ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΎΡ ΠΎΡΡΠ΅ΠΎΠΊΠ»Π°ΡΡΠΎΠ³Π΅Π½Π΅Π·Π° ΠΈ OPG β Β«ΡΠ΅ΡΠ΅ΠΏΡΠΎΡ-Π»ΠΎΠ²ΡΡΠΊΡΒ», ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠΈΠΉ RANKL ΠΈ, ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ, Π±Π»ΠΎΠΊΠΈΡΡΡΡΠΈΠΉ ΠΎΡΡΠ΅ΠΎΠΊΠ»Π°ΡΡΠΎΠ³Π΅Π½Π΅Π·.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠ‘ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ RANKL Π±ΡΠ»Π° Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ, Π° ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ OPG ΠΈ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅Β OPG/RANKL ΠΎΠΊΠ°Π·Π°Π»ΠΎΡΡ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π²ΡΡΠ΅, ΡΠ΅ΠΌ Ρ ΠΌΡΠΆΡΠΈΠ½ Π±Π΅Π· ΠΠ‘. ΠΠ°ΠΈΠ±ΠΎΠ»ΡΡΠ°Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ OPG Π·Π°ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π½Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΒ Π°ΠΊΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΠΎΡΠΌΠΎΠΉ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, ΡΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ ΡΠ°Π½Π½Π΅ΠΉ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠ°Π΄ΠΈΠ΅ΠΉ. ΠΠ΅ Π²ΡΡΠ²Π»Π΅Π½ΠΎ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΡΡΠΎΠ²Π½Ρ RANKL ΠΎΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ ΠΠ‘, ΠΎΠ΄Π½Π°ΠΊΠΎ ΠΎΡΠΌΠ΅ΡΠ΅Π½Π° ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΡ ΠΊ Π½Π΅Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ Π΅Π³ΠΎ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ Π²Π½Π΅ΡΠΊΠ΅Π»Π΅ΡΠ½ΡΡ
ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΉ ΠΠ‘, Π²ΡΡΠΎΠΊΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ, Π²ΡΡΠΎΠΊΠΈΠΌ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌ ΠΊΠ»Π°ΡΡΠΎΠΌ ΠΈΒ ΠΏΠΎΠ·Π΄Π½Π΅ΠΉ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠ°Π΄ΠΈΠ΅ΠΉ ΠΠ‘.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ OPG ΠΈ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ OPG/RANKL ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ ΡΠ΅ΠΌ, ΡΡΠΎ 94%Β ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΈΠΌΠ΅Π»ΠΈ ΠΏΠΎΠ·Π΄Π½ΡΡ ΡΡΠ°Π΄ΠΈΡ ΠΠ‘, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡΡΡ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΡΠΈΠ½Π΄Π΅ΡΠΌΠΎΡΠΈΡΠΎΠ². ΠΠ°Π½Π½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ, Π²Π΅ΡΠΎΡΡΠ½ΠΎ, ΠΌΠΎΠ³ΡΡ Π½ΠΎΡΠΈΡΡ ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΎΡΠ½ΡΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ Π² ΠΎΡΠ²Π΅Ρ Π½Π° Π½Π΅Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ RANKL ΠΈ ΡΡΠΈΠ»Π΅Π½ΠΈΠ΅ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠ΅Π·ΠΎΡΠ±ΡΠΈΠΈ