Perspectives of using sodium alginate with different molecular weight in the complex cancer therapy

The article presents the results of screening research of influence of sodium alginate with different molecular weight on the development of transplantable tumor in mice and the effectiveness of cytostatic treatment. It was determined that sodium alginates with both high (М = 403 kDa) and low (M = 1-10 kDa and M = 1 kDa) molecular weight suppress growth of Ehrlich ascites carcinoma; using sodium alginate (M = 20-30 kDa) in the scheme of chemotherapy increases effectiveness of treatment. Alginates with low molecular weight arrest development of dissemination of Lewis lung carcinoma and sodium alginates (M = 403 kDa and M = 20-30 kDa) in combination with cyclophosphan increase its antimetastatic effect

New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice

A new biological model of moderate inhibition of tumor growth and metastases with prolonged leukopenia on C57BI/6 mice with the Lewis Lung Carcinoma was designed. The model was created by the injection of cyclophosphamide (dose 83.3 mg/kg) on 6th, 12th, 18th days after tumor cells transplantation on animals. Experiment showed that 3-fold cyclophosphamide use leads to growth of primary tumor and metastases inhibition. Tumor growth inhibition was 34 % on 21st day after cyclophosphamide inject. The number of metastases decreased by 4.7 times (p < 0,01). Metastatic area reduced. Metastasis frequency made 100 %. In addition, the course of cyclophosphamide application caused inhibition of granulocytic and lymphoid hematopoiesis. The reducing the number of segmented neutrophils and lymphocytes was showed on the 3rd day after 1, 2 and 3 injections of cyclophosphamide. The model can be used to study the efficacy of drugs in tumor therapy and in correction of such toxic manifestation of chemotherapy as leukopenia

ДОКЛИНИЧЕСКОЕ ИССЛЕДОВАНИЕ ЛЕКАРСТВЕННОЙ ФОРМЫ α(1;2)-L-РАМНО-α(1;4)-D-ГАЛАКТОПИРАНОЗИЛУРОНАНА ИЗ КОРНЕВИЩ АИРА БОЛОТНОГО ACORUS CALAMUS L. В ОНКОЛОГИЧЕСКОМ ЭКСПЕРИМЕНТЕ

α(1,2)-L-ramno-α(1,4)-D-galaktopiranoziluronan from rhizomes Acorus calamus L. administered intravenously enhances the antitumor and antimetastatic efficacy of cyclophosphamide in mice with Lewis lung carcinoma, lung cancer – 67 and melanoma B-16.Показано, что разработанная для инъекционного применения лекарственная форма α(1,2)-L-рамно-α(1,4)-D галактопиранозилуронана из корневищ аира болотного (Acorus calamus L.) при внутривенном введении повышает противоопухо левую и антиметастатическую эффективность циклофосфана у мышей с карциномой легких Льюис, раком легкого-67 и меланомой В-16

PRECLINICAL STUDIES OF α(1,2)-L-RAMNO-α(1,4)-D-GALACTOPIRANOZILURONAN FROM RHIZOMES ACORUS CALAMUS L. IN CANCER EXPERIMENT

α(1,2)-L-ramno-α(1,4)-D-galaktopiranoziluronan from rhizomes Acorus calamus L. administered intravenously enhances the antitumor and antimetastatic efficacy of cyclophosphamide in mice with Lewis lung carcinoma, lung cancer – 67 and melanoma B-16