Россия и Глобальный экологический фонд: 25 лет сотрудничества

Studies the experience of cooperation between the Global Environment Facility (GEF) and Russia with the focus on the planned and already implemented environmental projects of the Global Environment Facility in Russia. Analyzes the main activities of the Fund and the features of GEF’s environmental projects in Russia, evaluates the prospects for further cooperation. Presents the classification of environmental projects supported by the GEF depending on the scale of funding. Examines the mechanism and the degree of participation of stakeholders (Russia and GEF) in financing environmental projects in our country. It is pointed out that Russia is of great investment interest for the Global Environmental Facility, especially in the implementation of projects on biodiversity conservation, combating global climate change and protecting international waters. Considers the prospects for a possible development of Russia’s cooperation with the GEF in addressing ecological problems.Исследуется опыт сотрудничества России и Глобального экологического фонда (ГЭФ). В фокусе внимания находятся проекты Глобального экологического фонда, запланированные и реализованные на территории России. Проанализированы основные направления и масштабы финансовой поддержки экологических проектов в России. Представлена классификация экологических проектов, поддерживаемых ГЭФ, в зависимости от масштабов финансирования. Рассмотрен механизм и степень участия заинтересованных сторон (России и ГЭФ) в финансировании проектов по сохранению окружающей среды в нашей стране. Установлено, что Россия представляет для Глобального экологического фонда большой инвестиционный интерес, особенно в реализации проектов по сохранению биоразнообразия, борьбы с изменением глобального климата и защиты международных вод. Показано также, что средства фонда являются важным дополнительным инструментом в решении экологических проблем в России, которая за 25-летнюю историю сотрудничества с ГЭФ получила от фонда более 4 млрд долл. на реализацию на своей территории 90 проектов в области сохранения окружающей среды. Рассмотрены перспективы возможного расширения сотрудничества России с ГЭФ в решении экологических проблем

ОТДЕЛЕНИЕ КРИЗИСНЫХ СОСТОЯНИЙ И ПСИХОСОМАТИЧЕСКИХ РАССТРОЙСТВ НИИ СП ИМ. Н.В. СКЛИФОСОВСКОГО: ОТ СОЗДАНИЯ ДО НАШИХ ДНЕЙ, ЭТАПЫ И ПЕРСПЕКТИВЫ РАЗВИТИЯ

Department of crisis conditions and psychosomatic disorders of Sklifosovsky Research Institute for Emergency Medicine: from creation to the present day, the stages and prospects of development.Отделение кризисных состояний и пси- хосоматических расстройств НИИ СП им. Н.В. Склифосовского: от создания до наших дней, этапы и перспективы развития

Exact solutions for equilibrium configurations of charged conducting liquid jets

A wide class of exact solutions is obtained for the problem of finding the equilibrium configurations of charged jets of a conducting liquid; these configurations correspond to the finite-amplitude azimuthal deformations of the surface of a round jet. A critical value of the linear electric charge density is determined, for which the jet surface becomes self-intersecting, and the jet splits into two. It exceeds the density value required for the excitation of the linear azimuthal instability of the round jet. Hence, there exists a range of linear charge density values, where our solutions may be stable with respect to small azimuthal perturbations.Comment: 7 pages, 5 figures, to appear in Physical Review

Clinical and instrumental associations of knee osteoarthrosis and pathology of the veins of the lower extremities

Knee osteoarthritis (OA) and varicose disease of the lower extremities (VD) are two diseases common in middle– aged and older women. Questions about whether their combination is accidental or natural and whether VD affects the course and severity of OA, remain unresolved.The aim of the study was to look for the possible association between knee OA and lower limb vein pathology on the basis of clinical and modern instrumental investigation sand to study the effect of the VD on the clinical manifestations and severity of knee OA.Materials and methods. A case-control study was conducted in 85 women 40–60 years old with knee OA diagnosed in accordance with the criteria of ACR (1986) and 50 women of the same age without signs of knee OA. Women of both groups were evaluated for complaints and objective examination with an emphasis on diseases of the joints and veins of the lower extremities, radiography of the knee joints, ultrasound duplex scanning of the veins of the lower extremities. The severity of OA was assessed by the Lequenne indices. The clinical assessment of venous pathology was carried out according to the CEAP classification.Results. Patients with knee OA more often than their peers without joint pathology have VD (43% vs 22%; p=0.015), signs of chronic venous insufficiency (28% vs 12%; p=0.03), as well as valve failure of several lower limb veins simultaneously (53% vs 20%; p=0.0004). After correction by body mass index, the association of knee OA with detected vascular pathology remained clinically and statistically significant. The presence of VD with moderate manifestations of chronic venous insufficiency, as well as ultrasound signs of venous pathology, was not associated with the clinical signs and course of knee OA.Conclusions. Knee OA in middle-aged and older women, regardless of body mass index, is associated with VD and ultrasound signs of simultaneous valves failure of several veins. Manifestations of chronic venous insufficiency did not affect the clinical picture and severity of knee OA

3D organotypic cell structures for drug development and Microorganism-Host interaction research

The article describes a new method of tissue engineering, which is based on the use of three-dimensional multicellular constructs consisting of stem cells that mimic the native tissue in vivo-organoid

Dynamics of the Free Surface of a Conducting Liquid in a Near-Critical Electric Field

Near-critical behavior of the free surface of an ideally conducting liquid in an external electric field is considered. Based on an analysis of three-wave processes using the method of integral estimations, sufficient criteria for hard instability of a planar surface are formulated. It is shown that the higher-order nonlinearities do not saturate the instability, for which reason the growth of disturbances has an explosive character.Comment: 19 page

Antimicrobial resistance in clinical <I>Escherichia coli</I> isolates obtained from animals

The article presents data on the phenotypic and genotypic characteristics of antimicriobial resistance in Escherichia coli clinical isolates recovered from bovine microbiota (secretions from mammary glands, cervical swabs). 127 Escherichia coli isolates were studied, i.e. 44 from mammary glands secretions and 83 from cervical swabs. Disk diffusion method was used to study antimicrobial resistance of the cultures; minimum inhibitory concentrations of antimicrobials were determined in a serial dilution method; resistance genes were detected by polymerase chain reaction. The carried out research demonstrates a wide distribution of the isolates belonging to the phenotype resistant to ansamycins (rifampicin), semi-synthetic penicillins (ampicillin and amoxicillin), tetracyclines (doxycycline). The isolates showed a lower level of resistance to macrolides (azithromycin), amphenicols (levomycetin) and aminoglycosides (tobramycin). It was found that Escherichia coli clinical isolates are sensitive to third-generation cephalosporins and fluoroquinolone antimicrobials. However, since 28.46% of cultures demonstrate intermediate resistance to third-generation cephalosporins and 49.02% of Escherichia coli DNA samples isolated from mammal gland secretions had blaDHA gene associated with resistance to this group of antimicrobials, these antimicrobials could be hardly recommended as antibiotics of choice. Absence of VIM carbapenemase-encoding gene in the DNA of the recovered isolates and a low level of phenotypic resistance (10.22% of isolates from cervical swabs) can be one of the reasons for recommending first-line carbapenems as antibiotics of choice to treat animal diseases associated with Escherichia coli, along with fluoroquinolones as reserve antimicrobials. It was found that the recovered Escherichia coli isolates are more sensitive to combination antibiotics than to mono-antibiotics

MOLECULAR GENETIC ANALYSIS OF INFECTION AGENTS OF FARM ANIMALS ANAPLASMOSIS ON THE TERRITORY OF WESTERN AND EASTERN SIBERIA

A total of 452 blood samples of cattle, sheep and goat collected in different regions of Altai Republic, Altai region, Novosibirsk and Irkutsk regions were examined on the presence of Anaplasma DNA using nested PCR with subsequent sequencing of PCR fragments. Anaplasma DNA was found in all examined blood samples of goat, 75.2 % samples of sheep, and 49.3 % samples of cattle. A molecular genetic analysis has demonstrated that intraerythrocytic Anaplasma ovis circulates in goat and sheep blood, while an intraerythrocytic Anaplasma sp. Omsk and a new intraerythrocytic Anaplasma sp. Sibl22, which cannot be attributed to any known species, circulate in cattle blood. In addition to intraerythrocytic Anaplasma, DNA of monocytic Anaplasma bovis was found in one blood sample of cattle

Frailty and age dynamics of separate clinical indicators in patients of therapeutic profile

Age-related dynamics of body homeostasis individual indicators in patients with risk of developing frailty and without frailty was studied in the research. Clinical indicators mostly associated with age were determined: muscle strength, glomerular filtration rate, total protein, potassium, hemoglobin, alanine aminotransferase activity, and blood plasma glucose. The contribution of reduced overall renal function, as well as anabolic activity of the liver in the development of age-related changes and frailty was studie