POSSIBILITIES OF ATTRACTION OF INVESTMENTS AND ALLOCATION OF RISKS IN PROJECTS USING THE MECHANISM PUBLIC-PRIVATE PARTNERSHIPS

The article describes a new form of attracting investment in infrastructure projects with using mechanisms of public-private partnerships. The risk allocation between the project participants, in order to minimize risk and avoid negative developments in the implementation of projects. Discusses the importance of technological and price audit to ensure effective cost solutions when implementing projects based on public-private partnerships

POSSIBILITIES OF ATTRACTION OF INVESTMENTS AND ALLOCATION OF RISKS IN PROJECTS USING THE MECHANISM PUBLIC-PRIVATE PARTNERSHIPS

The article describes a new form of attracting investment in infrastructure projects with using mechanisms of public-private partnerships. The risk allocation between the project participants, in order to minimize risk and avoid negative developments in the implementation of projects. Discusses the importance of technological and price audit to ensure effective cost solutions when implementing projects based on public-private partnerships

Definition of industrial enterprises development conditions and new approaches to resources using

The article presents an analysis of the conditions required to provide the industrial sustainable development in the digital transformations. A study has been carried out that determines the complementary assets role in modelling the enterprises development management processes operating in the context of ecosystem interactions in order to determine the properties of complementary interactions that contribute to the further value formation as a result of controlled changes in interactions by activity type or by product type. It is proposed to establish interactions by economic activity types presented in the Russian Classification of Economic Activities, which will allow us to determine the maximum possible profitability as a condition of complementarity from the main activity type and additional incoming types. The complementarity signs, which make it possible to achieve the required development and sustainability level in the ecosystem, have been determined

Advantages of BIM-modeling in the investment and innovation sector in the context of digital transformations of the industry

Approaches to the use of BIM-modeling in construction, methods of its implementation, standardization of parameters of investment activity of projects and its stages are considered. The key points in the organization of digital management at the enterprise were highlighted. The digital experience of foreign countries on the introduction and development of BIM-technologies in construction and the main advantages of the introduction of digital technologies in construction are considered. It is revealed that the digital transformation in the construction industry requires the creation of an appropriate institutional environment and the organization of its functioning in the general digital ecosystem. The concept of a functioning BIM environment with a digital environment is proposed as a part of the implementation of investment project activities in construction

Current management of the stability of organizations of the investment and construction complex in crisis situations

The article сonsiders topical issues of managing the economic stability of organizations in a crisis. The authors substantiate the need to study regional trends as an integral part of the anticrisis program at the regional level. Early diagnosis of crisis phenomena in the economy proves that a sufficiently high level of socio-economic development does not yet ensure complete economic security and the ability to withstand the threats posed by the unbalanced structure of the economy. Based on this, the problems in the field of ensuring the stability of organizations in the conditions of crises have been analysed and generalized. The problems faced by enterprises and organizations of the investment and construction sector of the economy have been considered. In methodological terms, the authors propose to use a system of indicative analysis and regulation of production and economic activities of enterprises of the real sector of the economy, as an organizational tool for resolving crisis situations in the economy. The study justifies the necessity of the introduction of digital technologies, on the basis of which it is possible to quickly implement the tasks set and achieve the expected results. The authors emphasize that we need our own anticrisis programs that to help maintain the sustainable functioning of organizations in the conditions of crisis phenomena

Current views on the role of fatty acids in the diagnosis of cardiovascular diseases (review)

An additional informative tool in the diagnosis of cardiovascular diseases in the early stages can be the analysis of changes in the fatty acid profile, which can be considered as a marker of various pathological conditions. The study of the effects of fatty acids and the mechanisms of changes in the fatty acid profile in connection with cardiovascular diseases remains relevant. We have analyzed modern data from foreign and domestic literature on issues related to the importance of fatty acids as possible markers in the diagnosis of cardiovascular diseases. Basic information about the structure of fatty acids, their functions in the human body, the relationship between the level of free fatty acids and indicators of the development of pathological processes of the cardiovascular system is presented. The factors influencing the dynamics of fatty acid concentrations both in normal conditions and during the development of pathological processes are reflected. The processes of biochemical modification of the fatty acid composition of the lipid matrix of the cell membrane are considered. The expediency of using fatty acids, together with some protein markers in the diagnosis of diseases of the cardiovascular system, has been shown. The collection and analysis of the accumulated information on the role of fatty acids helps to optimize the use of laboratory markers to determine the stages of pathogenesis of circulatory organ damage, to develop a system for evaluating the effectiveness of therapy for cardiovascular diseases, and to create a set of laboratory and instrumental tests for monitoring the condition of patients

Echohysterosalpingography: pros and cons. A systematic review

Background. Infertility is becoming ever more pressing a problem by year in Russia and worldwide. Tubal-peritoneal infertility is most frequent, with the prevalence of 42.5-80.5% in various estimates. Echohysterosalpingography is considered the today’s “gold standard” in tubal-peritoneal infertility diagnosis in women. This method is known to possess a series of limitations and adverse consequences due to painful sensations during and after check-ups that psychologically afflict women.Objectives. An overview of current methods for inspecting fallopian tubes in reproductively impaired patients to inform promising diagnostic research.Methods. Publications were mined and analysed in the PubMed, eLibrary, Web of Science, Cochrane Library and Cyberleninka electronic databases. The query terms were: echohysterosalpingography [эхогистеросальпингография], echohysterography [эхогистерография], infertility [бесплодие], pregnancy planning [планирование беременности], fallopian patency [проходимость маточных труб], ultrasonic diagnosis [ультразвуковая диагностика], submucous myomatous node [субмукозный миоматозный узел], incompetent uterine scar [несостоятельный рубец на матке], niche [ниша]. The topic selected was female infertility, particularly, the use of echohysterosalpingography in fallopian diagnosis in reproductively impaired women.Results. The review covers 52 sources of the total 118 analysed. Current published evidence and its review identify a notable success of imaging techniques in the fallopian tube diagnosis in women with reproductive problems. The continually developing echohysterosalpingography technique is considered more promising for routine use. Techniques gain more value in analyses of implantation failures. The main challenges in current radiodiagnosis and monitoring of fallopian lesions at a background therapy are the inspection standardisation, disease classification, imaging diagnostic accuracy and prognostic value evaluation in patients with reproductive loss and infertility.Conclusion. The prospective routes of research comprise the definition of optimal check-up terms, echohysterography and echohysterosalpingography diagnostic criteria descriptiveness, improving prognosis in the carrying of pregnancy and treatment efficacy control. A timely and accurate diagnosis of uterus and fallopian tubes is of paramount importance to sustain the women’s reproductive health

Overview of metabolomic markers used for diagnosing cardiovascular diseases

At present, metabolomics is an intensively developing approach to the specific diagnosis of cardiovascular diseases. Metabolic analysis allows the study of complete metabolomic profiles and their deviations resulting from changes, for example, gene and RNA expression, protein activity, or environmental factors. Analysis of the metabolomic blood profile helps in solving a large number of scientific and clinical problems, one of which is the search for markers of diseases, in particular, cardiovascular diseases (CVD). Aim of the study was to investigate metabolomic markers used for the diagnosis of cardiovascular diseases on the basis of literature data. Material and methods. The literature data was analyzed for key words: cardiovascular diseases, metabolomics, metabolic profile, metabolomic markers in da- tabases PubMed, Scopus, Web of Science, CyberLeninka, PatentDB, Science Direct Open Access, eLibrary. Results. Analysis of literature data and patent search confirms the high importance of metabolomic markers in the diagnosis of CVD. In the patent literature, BNP/NT-proBNP is most common used as a metabolic marker of CVD (11.27 %). The use of CRP (8.99 %) and troponin (8.49 %) is also common. PICP (0.02 %), sVCAM-1 (0.09 %), stimulating growth factor ST-2 (0.12 %) and thrombomodulin (0.12 %) as metabolic markers of CVD. Conclusions. Against the backdrop of analytical methods, metabolomics is the most important diagnostic area. At the same time, it should be noted that by combining the results of the analysis of metabolic studies with others, for example, genomic and proteomic, one can get a complete picture of the pathogenesis of diseases, assess the risk of complications, and also determine the effectiveness of the treatment

Two-dimensional discrete wavelet analysis of multiparticle event topology in heavy ion collisions

The event-by-event analysis of multiparticle production in high energy hadron and nuclei collisions can be performed using the discrete wavelet transformation. The ring-like and jet-like structures in two-dimensional angular histograms are well extracted by wavelet analysis. For the first time the method is applied to the jet-like events with background simulated by event generators, which are developed to describe nucleus-nucleus collisions at LHC energies. The jet positions are located quite well by the discrete wavelet transformation of angular particle distribution even in presence of strong background.Comment: 6 pages, 6 figure

Роль ультразвуковой оценки коэффициента массы селезенки в динамике наблюдения детей с хронической формой ВЭБ-инфекцией

Purpose of the study: to show the significance of ultrasound diagnostics in assessing the dynamics of the spleen mass coefficient in children of various age against the background of a chronic form of EBV virus.Materials and methods. The study was performed on 146 children aged 3 to 18 years suffering from chronic EBV virus. Depending on age, the children were divided into 3 groups. Group 1 included 63 patients aged 3 to 7 years; Group 2 consisted of 28 children aged 8 to 11 years; Group 3 included 55 children aged 12 to 18 years. The clinical, laboratory and ultrasound examination was conducted including ultrasound of the spleen with the further determination of its mass coefficient (SMC).Results. In the acute period of EBV virus, children of all age groups revealed an increase in SMC, while the maximum increase was observed in children aged 3 to 7 years and amounted to 6,88. Against the background of a complete clinical and laboratory recovery in this age group, the SMC remained at the level of 4.66 and did not reach the average values of healthy children of the same age. The follow-up dynamics for 15–18 months demonstrated the normalization of the SMC to the average values of healthy patients in accordance with their age (in children aged 12 years and older).Findings. Children in the age group from 3 to 7 years old had the maximum value of the spleen mass coefficient, both in the acute period and after complete clinical and laboratory recovery. The use of ultrasound technique with the assessment of the spleen mass coefficient in the chronic course of EBV virus allows expanding and determining the children contingent for further dynamic monitoring for prevention of possible complications.Цель исследования: показать значимость ультразвуковой диагностики  в оценке динамики коэффициента массы селезенки у детей различных возрастных групп на фоне хронической формы ВЭБ - инфекции.Материалы и методы. В исследование включили 146 детей в возрасте от 3 до 18 лет с хронической формой ВЭБ - инфекции. В зависимости от возраста, дети были разделены на 3 группы. В 1-ю группу вошло 63 пациента от 3 до 7 лет; 2 – ю группу составили 28 детей с 8 до 11 лет; 3 – ю группу - 55 детей от 12 до 18 лет. Проводили клиническое, лабораторное и ультразвуковое обследование, включая ультразвуковое исследование селезенки с определением коэффициента массы (КМС).Результаты. В остром периоде ВЭБ инфекции дети всех возрастных групп имели увеличение КМС, при этом максимальное увеличение отмечалось у детей от 3 до 7 лет и колебалось в диапазоне от 4,9 до 9,2. При наличии полного клинико-лабораторного выздоровления у данного возрастного контингента КМС оставался на уровне 4,2-5,8 и не достигал средних значений здоровых детей данного возраста. Динамика наблюдения в течение 15-18 месяцев выявляла нормализацию КМС до средневозрасных значений здоровых пациентов у детей 12 лет и старше.Выводы. Дети в группе от 3 до 7 лет имели максимальное значение коэффициента массы селезенки, как в остром периоде, так и после полного клинико - лабораторного выздоровления. Применение ультразвуковой методики с оценкой коэффициента массы селезенки при хроническом течении ВЭБ-инфекции позволяет расширить и определить контингент детей для дальнейшего динамического наблюдения с целью профилактики возможных осложнений