The ability to use a clinical neonatal assessment scale to make a decision about transportability

Perinatal routing ensures increased survival among preterm infants. Early admission to a high-level neonatal care facility is also associated with lower morbidity in this patient population. A significant number of scales have been proposed to assess neonatal severity, predicting morbidity and risk of death. However, the comparison of the decision of the transport team with the recommendations of the scales is poorly understood.Перинатальная маршрутизация обеспечивает рост выживаемости среди недоношенных новорожденных. Раннее поступление в учреждение высокого уровня неонатальной помощи также ассоциировано с меньшей заболеваемостью в этой категории пациентов. Для оценки тяжести состояния новорожденных предложено значительное число шкал, прогнозирующих заболеваемость и риск смерти. Однако сопоставление решения транспортной бригады с рекомендациями шкалы мало изучены

Pharmacoeconomic analysis of the use of first- and second-line drugs in the treatment of multiple sclerosis

Objective: to make a pharmacoeconomic comparison of the administration of first- and second-line drugs in the treatment of multiple sclerosis through cost, cost-effectiveness, and budget impact analyses using the 2015 state prices.Material and methods. A pharmacoeconomic analysis was carried out on the basis of the data available in the literature on trials of the effects of the drugs on the rates of exacerbations and disability. On calculating, the authors took into account the current standards for the out- and inpatient management of patients with this nosological entity in accordance with the compulsory health insurance (CHI) program; prices for state drug purchases in March 2015; prices for medical services in compliance with the CHI standards in Moscow in 2015; the average sizes of minimum wage, salary, and disability grants with consideration for a discount rate of 3%. The cost-effectiveness and budget impact analyses were performed for intramuscular interferon (INF)-β1a (avonex, 30 μg), subcutaneous INF-β1a (rebif, 44 μg), subcutaneous INF-β1b (ronbetal, 8,000,000 IU), subcutaneous INF-β1b (betaferon, 9,600,000 IU), subcutaneous glatiramer acetate (copaxone, 20 mg), intravenous natalizumab (tyzabri, 300 mg), and oral fingolimod (gilenya, 0.5 mg).Results and discussion. The second-line drug tyzabri outperforms the first-line agents for cost-effectiveness. The first-line drugs betaferon and copaxone is slightly exceeded in this indicator by tyzabri; the other both first- and second-line agents compared are all the more inferior in this indicator. The budget impact analysis has shown that the cost of the second-line drugs was higher than that of the first-line ones

Plasticity of Mycoplasmas: Changes in the Genomic Profile, as well as in the Cellular and Vesicular Proteomes of the Acholeplasma laidlawii in Adapting the Bacterium to Different Environmental Conditions

© 2016, Springer Science+Business Media New York.For the first time as a result of the comparative analysis of proteomes of cells and extracellular vesicles, as well as the complete nucleotide sequence of Acholeplasma laidlawii cells under various conditions of growth of the mycoplasma, the evidence of a high level of plasticity of this bacterium, providing a rapid adaptation to stressors associated with the SOS response, was obtained. The battery of genes with targeted potential for the infekta control system using CRISPR tools was revealed

Modulational instability, solitons and beam propagation in spatially nonlocal nonlinear media

We present an overview of recent advances in the understanding of optical beams in nonlinear media with a spatially nonlocal nonlinear response. We discuss the impact of nonlocality on the modulational instability of plane waves, the collapse of finite-size beams, and the formation and interaction of spatial solitons.Comment: Review article, will be published in Journal of Optics B, special issue on Optical Solitons, 6 figure

Tracking azimuthons in nonlocal nonlinear media

We study the formation of azimuthons, i.e., rotating spatial solitons, in media with nonlocal focusing nonlinearity. We show that whole families of these solutions can be found by considering internal modes of classical non-rotating stationary solutions, namely vortex solitons. This offers an exhaustive method to identify azimuthons in a given nonlocal medium. We demonstrate formation of azimuthons of different vorticities and explain their properties by considering the strongly nonlocal limit of accessible solitons.Comment: 11 pages, 7 figure

Threat-measuring capabilities of the NTISS scale in the pre-transport phase of neonatal preparation.

The aim of the study was to determine the ability of the NTISS scale to predict neonatal outcomes during the pre-transplant preparation phase, depending on the score obtained.Цель исследования – определить возможности шкалы NTISS для прогнозирования исходов у новорожденных на этапе предтранспортной подготовки в зависимости от полученной оценки