7,878 research outputs found
Recommended from our members
Ethics and Design in the Brazilian Context
Often driven by practical and immediate requirements, more and more people are incorporating technology into a variety of aspects of their lives, often without reflecting on the consequences of using them. On the other hand, studies on interactive system development that lead to behavioral change have been gaining ground on the agenda of large HCI conferences. This movement brings to the forefront the fundamental issues of ethics in design and technology use. A designer’s intentions, when directing certain actions or behaviors, are not always explicit or desired by the stakeholders affected by the use of the technology. Systems that induce an undesired purchase, or even those that use conditioning strategies to cause a behavioral change are examples of such intentions. The challenge proposed is therefore about the relationship between design and personal freedom in a way that these technology users do not become victims, either passively or submissively, of the effects of its use. This advance allows for the redefinition of the relationship between man and technology, and the application of new forms of designing and developing interactive systems that take into account the ethical aspects of this relationship
A Low Rhodium Content Smart Catalyst for Hydrogenation and Hydroformylation Reactions
Abstract: This paper describes the preparation, broad characterization and study of activity in hydrogenation and hydroformylation reactions of an easily produced 0.18% Rh/Al2O3. Analytical studies on fresh and recycled samples shed light on the smart properties of such catalyst. Results showed high activity as well as fine/excellent chemoselectivity or regioselectivity, characteristics that may suggest a wide range of applicability. Graphic Abstract: The low metal content catalyst 0.18% Rh/Al2O3 was very active in both hydrogenation and hydroformylation reactions so providing intermediates for valuable APIs, as Nabumetone and Eletriptan, and a fragrance with a fresh, green-floral smell, that recalls scent of lily of the valley.[Figure not available: see fulltext.
Between Here and There: Surveying the Global Work of Diaspora, Migration, and Mobility-Engaged Museums
Diaspora, migration, and mobility-engaged museums are a growing sector amongst global cultural institutions. These museums play a significant role in shaping understandings of migration and representing diaspora identities, cultures, and experiences. Through their work, they also serve an increasingly diplomatic function in fostering mutual understanding amongst various groups and communities. At a time when migration is increasingly contested and politicized, the work of these institutions has never been more pressing. This report presents a global survey of the work of diaspora, migration, and mobility-engaged museums. Our study focused on understanding the sector, including the range and scope of institutions and their approaches, as well as their social and diplomatic impacts. This report shares our findings, which include an assessment of how diaspora and migration are defined in the sector, a typology of museums, their representational strategies, and an analysis of the cultural diplomacy work of these museums. Our research demonstrates the ability of these institutions to unsettle traditional understandings of culture and identity as bounded, singular, and homogenous and to foster narratives that bridge local and global connections
The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions.
When present, structural disorder makes it very challenging to characterise the conformational properties of proteins. This is particularly the case of proteins, such as the oncogene protein E7 of human papillomavirus type 16, which contain both ordered and disordered domains, and that can populate monomeric and oligomeric states under physiological conditions. Nuclear magnetic resonance (NMR) spectroscopy is emerging as a powerful method to study these complex systems, most notably in combination with molecular dynamics simulations. Here we use NMR chemical shifts and residual dipolar couplings as structural restraints in replica-averaged molecular dynamics simulations to determine the free energy landscape of E7. This landscape reveals a complex interplay between a folded but highly dynamical C-terminal domain and a disordered N-terminal domain that forms transient secondary and tertiary structures, as well as an equilibrium between a high-populated (98%) dimeric state and a low-populated (2%) monomeric state. These results provide compelling evidence of the complex conformational heterogeneity associated with the behaviour and interactions of this disordered protein associated with disease.University of Florence (Italy)
“Science without borders” of the Brazilian Ministry of Science and Technology (CNPq
Developement of real time diagnostics and feedback algorithms for JET in view of the next step
Real time control of many plasma parameters will be an essential aspect in
the development of reliable high performance operation of Next Step Tokamaks.
The main prerequisites for any feedback scheme are the precise real-time
determination of the quantities to be controlled, requiring top quality and
highly reliable diagnostics, and the availability of robust control algorithms.
A new set of real time diagnostics was recently implemented on JET to prove the
feasibility of determining, with high accuracy and time resolution, the most
important plasma quantities. With regard to feedback algorithms, new
model–based controllers were developed to allow a more robust control of
several plasma parameters. Both diagnostics and algorithms were successfully
used in several experiments, ranging from H-mode plasmas to configuration with
ITBs. Since elaboration of computationally heavy measurements is often
required, significant attention was devoted to non-algorithmic methods like
Digital or Cellular Neural/Nonlinear Networks. The real time hardware and
software adopted architectures are also described with particular attention to
their relevance to ITER.Comment: 12th International Congress on Plasma Physics, 25-29 October 2004,
Nice (France
Simple and efficient water soluble thioligands for rhodium and iridium catalyzed biphasic hydrogenation
The activity of catalytic systems derived from the interaction between Rh(CO)2acac and [Ir(COD)Cl]2,
respectively, with the water soluble thioligands (L)-Cysteine (1) and (S)-Captopril (2), was tested in the
aqueous biphasic hydrogenation of some representative ,-unsaturated compounds as 2-cyclohexen-
1-one (I), trans-cinnamaldehyde (V) and [3-(1,3-benzodioxol-5-yl)-2-methylpropenal] (X), precursor of
the fragrance Helional® (XI). The precatalyst Rh/Cap was able to hydrogenate cyclohexenone even at low
pressure at 60 â—¦C in a neutral medium while Rh/Cy required either higher pressure and temperature or an
alkaline medium. The iridium based catalysts, Ir/Cy and Ir/Cap, showed an analogous trend though their
activities were lower than those of the related rhodium catalysts. All the catalysts were easily recycled
without significant loss of activity. The rhodium catalysts were also used in the hydrogenation of the
above aldehydes V and X and their activity was strongly enhanced when ethylene glycol was used as
organic solvent or co-solvent
Skin Lesion Analyser: An Efficient Seven-Way Multi-Class Skin Cancer Classification Using MobileNet
Skin cancer, a major form of cancer, is a critical public health problem with
123,000 newly diagnosed melanoma cases and between 2 and 3 million non-melanoma
cases worldwide each year. The leading cause of skin cancer is high exposure of
skin cells to UV radiation, which can damage the DNA inside skin cells leading
to uncontrolled growth of skin cells. Skin cancer is primarily diagnosed
visually employing clinical screening, a biopsy, dermoscopic analysis, and
histopathological examination. It has been demonstrated that the dermoscopic
analysis in the hands of inexperienced dermatologists may cause a reduction in
diagnostic accuracy. Early detection and screening of skin cancer have the
potential to reduce mortality and morbidity. Previous studies have shown Deep
Learning ability to perform better than human experts in several visual
recognition tasks. In this paper, we propose an efficient seven-way automated
multi-class skin cancer classification system having performance comparable
with expert dermatologists. We used a pretrained MobileNet model to train over
HAM10000 dataset using transfer learning. The model classifies skin lesion
image with a categorical accuracy of 83.1 percent, top2 accuracy of 91.36
percent and top3 accuracy of 95.34 percent. The weighted average of precision,
recall, and f1-score were found to be 0.89, 0.83, and 0.83 respectively. The
model has been deployed as a web application for public use at
(https://saketchaturvedi.github.io). This fast, expansible method holds the
potential for substantial clinical impact, including broadening the scope of
primary care practice and augmenting clinical decision-making for dermatology
specialists.Comment: This is a pre-copyedited version of a contribution published in
Advances in Intelligent Systems and Computing, Hassanien A., Bhatnagar R.,
Darwish A. (eds) published by Chaturvedi S.S., Gupta K., Prasad P.S. The
definitive authentication version is available online via
https://doi.org/10.1007/978-981-15-3383-9_1
- …