Expression of some molecular and biological markers in esophageal tumors of various stages and grades

Objectives: immunohistochemical study of the expression of molecular and biological markers (p53, bcl-2 and ki-67) in esophageal tumors of various stages and grades, and evaluation of the markers in the disease prognosis. Material and methods: the study included 30 patients of a retrospective group with stage II-III squamous cell carcinoma of the esophagus. Immunohistochemical study of paraffi n sections was performed using primary mouse monoclonal antibodies against p53, bcl-2 and ki67, and Reveal Polyvalent HRP-DAB Detection System. Results: diff erences in the rates and expression of molecular and biological markers (p53, bcl-2 and ki-67), controlling apoptosis and proliferation, depended on the tumor stage and grade. Conclusions: fdvanced cancer of the esophagus demonstrated an increase in rates and expression of p53+ and ki-67, as well as in the proliferative activity of tumor cells. Bcl-2 expression was more frequent and intensive in stage II tumors, compared to stage III. Esophageal tumors of higher grades were characterized with higher rates and expression of p53 and ki-67, and conversely for the bcl-2 expression. Th e revealed diff erences can be used in the disease prognosis

Determination of the orthotropic parameters of a representative sample by computed tomography

© 2019 IOP Publishing Ltd. The simulation of the stress-strain state of porous media is actual problem nowadays. The application of the mathematical apparatus of continuum mechanics to such media will make it possible to extend the scope of the problems to be solved. In this paper we study method of determination of mechanical properties in representative element bases on computer tomography data. To this task algorithm to create finite element grid connected with the data of the computed tomography was developed. Orthotopic properties can be determined by using target function. Unknown components of the target function are orthotropic directions. These directions can be determined by minimization of the target function. Rotating the matrix of anisotropic constants leads to components of the orthotopic tensor in orthotopic axes. These tensors are compared using of stress invariant

Determination of the orthotropic parameters of a representative sample by computed tomography

© 2019 IOP Publishing Ltd. The simulation of the stress-strain state of porous media is actual problem nowadays. The application of the mathematical apparatus of continuum mechanics to such media will make it possible to extend the scope of the problems to be solved. In this paper we study method of determination of mechanical properties in representative element bases on computer tomography data. To this task algorithm to create finite element grid connected with the data of the computed tomography was developed. Orthotopic properties can be determined by using target function. Unknown components of the target function are orthotropic directions. These directions can be determined by minimization of the target function. Rotating the matrix of anisotropic constants leads to components of the orthotopic tensor in orthotopic axes. These tensors are compared using of stress invariant

Robustness of Autoregressive Forecasting Under Bilinear Distortions

The paper is devoted to the investigation of bilinear stochastic time series model BL(p,0,1,1). The autoregressive forecasting statistic is considered under the mean square risk criterion; its robustness under bilinear distortions is evaluated

Groupe de sociétés. Sociétés fictives, Patrimoines distincts

International audience(Com. 19 mars 1996, Sté Lemphy maritima entreprise c/ Sté Zaatari et Bros, Rev. sociétés 1996.267, note P. Le Cannu, cette Revue, infra p. 686

Structural design method for constructions: Simulation, manufacturing and experiment

The development of additive manufacturing technology leads to new concepts for design implants and prostheses. The necessity of such approaches is fueled by patient-oriented medicine. Such a concept involves a new way of understanding material and includes complex structural geometry, lattice constructions, and metamaterials. This leads to new design concepts. In the article, the structural design method is presented. The general approach is based on the separation of the micro-and macro-mechanical parameters. For this purpose, the investigated region as a complex of the basic cells was considered. Each basic cell can be described by a parameters vector. An initializing vector was introduced to control the changes in the parameters vector. Changing the parameters vector according to the stress-strain state and the initializing vector leads to changes in the basic cells and consequently to changes in the microarchitecture. A medium with a spheroidal pore was considered as a basic cell. Porosity and ellipticity were used for the parameters vector. The initializing vector was initialized and depended on maximum von Mises stress. A sample was designed according to the proposed method. Then, solid and structurally designed samples were produced by additive manufacturing technology. The samples were scanned by computer tomography and then tested by structural loads. The results and analyses were presented

Studies of Structure and Impact Damage of Composite Materials by a Computer Tomograph

© 2020, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG. The paper discusses the possibilities of computed tomography in the study of the internal structure of samples of composite materials with different types of reinforcing the material. A technique has been developed for recording impact damage parameters on a stand with a vertically falling weight. Using CT data the character of the distribution of internal damages was carried out after a low-speed strike was studied. The unique technique allows reconstructing 3D geometry of the object and analyze object defects in spatial