517 research outputs found
Resolvent Analysis: With or Without Eddy Viscosity?
International audienceIn this study, estimations of the spatio-temporal power cross-spectral density based on the resolvent operator are compared to those obtained by direct numerical simulation (DNS) in the turbulent plane channel flow at Re Ï = 1007 by analysing separately the contribution of each temporal frequency Ï. The comparison is performed for spatial scales characteristic of buffer-layer and large-scale motions. Good agreement between the resolvent-based estimates and the statistics obtained by DNS is found when the resolvent operator is based on a linear model which includes the effect of an eddy-viscosity modelling the effect of turbulent Reynolds stresses. The agreement is further improved when a colored noise matching the measures is used instead of white noise in the forcing modelling. Such a good agreement is not observed when the eddy-viscosity terms are not included in the linear model. In this case, the estimation based on the resolvent is unable to select the right peak frequency and wall-normal location of buffer-layer motions
B Cells in the CNS at Postmortem Are Associated With Worse Outcome and Cell Types in Multiple Sclerosis
BACKGROUND AND OBJECTIVES: To define the clinical and pathologic correlations of compartmentalized perivascular B cells in postmortem progressive multiple sclerosis (MS) brains. METHODS: Brain slices were acquired from 11 people with secondary progressive (SP) MS, 5 people with primary progressive (PP) MS, and 4 controls. Brain slices were immunostained for B lymphocytes (CD20), T lymphocytes (CD3), cytotoxic T lymphocytes (CD8), neuronal neurofilaments (NF200), myelin (SMI94), macrophages/microglia (CD68 and IBA1), astrocytes (glial fibrillary acidic protein [GFAP]), and mitochondria (voltage-dependent anion channel and cytochrome c oxidase subunit 4). Differences in CD20 immunostaining intensity between disease groups and associations between CD20 immunostaining intensity and both clinical variables and other immunostaining intensities were explored with linear mixed regression models and Cox regression models, as appropriate. RESULTS: CD20 immunostaining intensity was higher in PPMS (Coeff = 0.410; 95% confidence interval [CI] = 0.046, 0.774; p = 0.027) and SPMS (Coeff = 0.302; 95% CI = 0.020, 0.585; p = 0.036) compared with controls. CD20 immunostaining intensity was higher in cerebellar, spinal cord, and pyramidal onset (Coeff = 0.274; 95% CI = 0.039, 0.510; p = 0.022) compared with optic neuritis and sensory onset. Higher CD20 immunostaining intensity was associated with younger age at onset (hazard ratio [HR] = 1.033; 95% CI = 1.013, 1.053; p = 0.001), SP conversion (HR = 1.056; 95% CI = 1.022, 1.091; p = 0.001), wheelchair dependence (HR = 1.472; 95% CI = 1.108, 1.954; p = 0.008), and death (HR = 1.684; 95% CI = 1.238, 2.291; p = 0.001). Higher immunostaining intensity for CD20 was associated with higher immunostaining intensity for CD3 (Coeff = 0.114; 95% CI = 0.005, 0.224; p = 0.040), CD8 (Coeff = 0.275; 95% CI = 0.200, 0.350; p < 0.001), CD68 (Coeff = 0.084; 95% CI = 0.023, 0.144; p = 0.006), GFAP (Coeff = 0.002; 95% CI = 0.001, 0.004; p = 0.030), and damaged mitochondria (Coeff = 3.902; 95% CI = 0.891, 6.914; p = 0.011). DISCUSSION: Perivascular B cells were associated with worse clinical outcomes and CNS-compartmentalized inflammation. Our findings further support the concept of targeting compartmentalized B-cell inflammation in progressive MS
Haldane-gap excitations in the low-H_c 1-dimensional quantum antiferromagnet NDMAP
Inelastic neutron scattering on deuterated single-crystal samples is used to
study Haldane-gap excitations in the new S=1 one-dimensional quantum
antiferromagnet NDMAP, that was recently recognized as an ideal model system
for high-field studies. The Haldane gap energies meV,
meV and meV, for excitations polarized along
the a, b, and c crystallographic axes, respectively, are directly measured. The
dispersion perpendicular to the chain axis c is studied, and extremely weak
inter-chain coupling constants meV and meV, along the a and b axes, respectively, are determined. The results
are discussed in the context of future experiments in high magnetic fields.Comment: 5 pages, 4 figures, submitted to Phys. Rev.
The Framingham cardiovascular risk score in multiple sclerosis
Background and purpose: Cardiovascular risk factors can increase the risk of multiple sclerosis (MS) and modify its course. However, such factors possibly interact, determining a global cardiovascular risk. Our aim was to compare the global cardiovascular risk of subjects with and without MS with the simplified 10-year Framingham General Cardiovascular Disease Risk Score (FR) and to evaluate its importance on MS-related outcomes. Methods: Age, gender, smoking status, body mass index, systolic blood pressure, type II diabetes and use of antihypertensive medications were recorded in subjects with and without MS to estimate the FR, an individualized percentage risk score estimating the 10-year likelihood of cardiovascular events. Results: In total, 265 MS subjects were identified with 530 matched controls. A t test showed similar FR in cases and controls (P = 0.212). Secondary progressive MS presented significantly higher FR compared to relapsing-remitting MS (P < 0.001). Linear regression analysis showed a direct relationship between FR and Expanded Disability Status Scale (P < 0.001) and MS Severity Scale (P < 0.001). Conclusion: The FR, evaluating the global cardiovascular health by the interaction amongst different risk factors, relates to MS disability, severity and course
An experimental measurement of the staggered magnetization curve for a Haldane spin chain
Long-range magnetic ordering in R_2 Ba Ni O_5 (R=magnetic rare earth)
quasi-1-dimensional mixed-spin antiferromagnets is described by a simple
mean-field model that is based on the intrinsic staggered magnetization
function of isolated Haldane spin chains for the Ni-subsystem, and single-ion
magnetization functions for the rare earth ions. The model is applied to new
experimental results obtained in powder diffraction experiments on Nd_2 Ba Ni
O_5 and Nd Y Ba Ni O_5, and to previously published diffraction data for Er_2
Ba Ni O_5. From this analysis we extract the bare staggered magnetization curve
for Haldane spin chains in these compounds.Comment: some revisions in text and figures 5 pages, 2 figures, PRL accepted
for publicatio
Spin-Vacancy-Induced Long-Range Order in a New Haldane-Gap Antiferromagnet
Magnetic susceptibility, high-field magnetization and inelastic neutron
scattering experiments are used to study the magnetic properties of a new S=1
quasi-1-dimensional antiferromagnet PbNi2V2O8. Inter-chain interactions are
shown to be almost, but not quite, strong enough to destroy the nonmagnetic
singlet ground state and the energy gap in the magnetic excitation spectrum.
Substituting nonmagnetic Mg (S=0) ions for Ni (S=1) induces a
magnetically ordered state at low temperatures. To our knowledge this is the
first observation of doping-induced long-range order in a Haldane-gap system.Comment: 5 pages including 4 figure
Magnetic excitations in coupled Haldane spin chains near the quantum critical point
Two quasi-1-dimensional S=1 quantum antiferromagnetic materials, PbNi2V2O8
and SrNi2V2O8, are studied by inelastic neutron scattering on powder samples.
While magnetic interactions in the two systems are found to be very similar,
subtle differences in inter-chain interaction strengths and magnetic anisotropy
are detected. The latter are shown to be responsible for qualitatively
different ground state properties: magnetic long-range order in SrNi2V2O8 and
disordered ``spin liquid'' Haldane-gap state in PbNi2V2O8.Comment: 15 figures, Figs. 5,9, and 10 in color. Some figures in JPEG format.
Complete PostScript and PDF available from
http://papillon.phy.bnl.gov/publicat.ht
Coexistence of Haldane gap excitations and long range antiferromagnetic order in mixed-spin nickelates R_2 Ba Ni O_5
The spin dynamics of the S=1 Ni-chains in mixed-spin antiferromagnets Pr_2 Ba
Ni O_5 and Nd_x Y_2-x Ba Ni O_5 is described in terms of a simple
Ginzburg-Landau Lagrangian coupled to the sublattice of rare-earth ions. Within
this framework we obtain a theoretical explanation for the experimentally
observed coexistence of Haldane gap excitations and long-range magnetic order,
as well as for the increase of the Haldane gap energy below the Neel point. We
also predict that the degeneracy of the Haldane triplet is lifted in the
magnetically ordered phase. The theoretical results are consistent with the
available experimental data.Comment: 4 pages, 1 figure, submitted to PRL An alternative derivation of main
results and new references adde
Proton spectra from Non-Mesonic Weak Decay of p-shell Lambda-Hypernuclei and evidence for the two-nucleon induced process
New spectra from the FINUDA experiment of the Non Mesonic Weak Decay (NMWD)
proton kinetic energy for 9(Lambda)Be, 11(Lambda)B, 12(Lambda)C, 13(Lambda)C,
15 (Lambda)N and 16(Lambda)O are presented and discussed along with the
published data on 5(Lambda)He and 7(Lambda)Li. Exploiting the large mass number
range and the low energy threshold (15 MeV) for the proton detection of FINUDA,
an evaluation of both Final State Interactions (FSI) and the two nucleon
induced NMWD contributions to the decay process has been done. Based on this
evaluation, a linear dependence of FSI on the hypernuclear mass number A is
found and for the two nucleon stimulated decay rate the experimental value of
Gamma2/Gammap=0.43+-0.25 is determined for the first time. A value for the two
nucleon stimulated decay rate to the total decay rate
Gamma2/GammaNMWD=0.24+-0.10 is also extracted.Comment: 11 pages and 2 figure
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