8 research outputs found
The Evolution of Romanian Tourism in the Last Decade
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Transformation of Tomato with the Melon 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Leads to Increase of Fruit Size
- Author
- Publication venue
- 'Japanese Society for Plant Cell and Molecular Biology'
- Publication date
- 01/01/2003
- Field of study
L-form-like colonies of Staphylococcus aureus induced by an extracellular lytic enzyme from Pseudomonas aeruginosa
- Author
- Publication venue
- 'American Society for Microbiology'
- Publication date
- Field of study
Restoration of blood flow by using continuous perimuscular infiltration of plasmid DNA encoding subterranean mole rat Spalax ehrenbergi VEGF
- Author
- Publication venue
- The National Academy of Sciences
- Publication date
- 02/04/2003
- Field of study
The optimal vector, regulatory sequences, and method of delivery of angiogenic gene therapy are of considerable interest. The Spalax ehrenbergi superspecies live in subterranean burrows at low oxygen tensions and its tissues are highly vascularized. We tested whether continuous perimuscular administration of Spalax vascular endothelial growth factor (VEGF) DNA could increase tissue perfusion in a murine hindlimb ischemia model. Placebo or VEGF ± internal ribosome entry site (IRES) was continuously administrated perimuscularly in the ischemic zone by using an infusion pump. None of the mice in the VEGF-treated group (>50 μg) developed visible necrosis vs. 33% of the placebo group. Microscopic necrosis was observed only in the placebo group. Spalax VEGF muscular infiltration resulted in a faster and more complete restoration of blood flow. The restoration of blood flow by VEGF was dose-dependent and more robust and rapid when using the VEGF–IRES elements. The flow restoration using continuous perimuscular infiltration was faster than single i.m. injections. Vessel density was higher in the VEGF and VEGF–IRES (−) groups compared with the placebo. Continuous perimuscular administration of angiogenic gene therapy offers a new approach to restore blood flow to an ischemic limb. Incorporation of an IRES element may assist in the expression of transgenes delivered to ischemic tissues. Further studies are needed to determine whether VEGF from the subterranean mole rat Spalax VEGF is superior to VEGF from other species. If so, 40 million years of Spalax evolution underground, including adaptive hypoxia tolerance, may prove important to human angiogenic gene therapy
Virtual tool for training and evaluation of problem-based engineering subjects
- Author
- Publication venue
- 'IOP Publishing'
- Publication date
- Field of study
Lithium: Sources, Production, Uses, and Recovery Outlook
- Author
- A Ebensperger
- A Yaksic Beckdorf
- B Schutz
- Commission to the European Parliament and Council
- DE Sullivan
- DR Wilburn
- E Hsiao
- European Automobile Manufacturers Association
- European Commission
- Gara Villalba Méndez
- J Sutter
- JR Cui
- K Yoshizuka
- L Talens Peiró
- Laura Talens Peiró
- Navigant Research
- O Takeda
- R Geyer
- R Lache
- Robert U. Ayres
- Roskill Information Services Ltd.
- United States Geological Survey
- WL Faith
- Y Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Stock Market Reaction to Green Vehicle Innovation
- Author
- A C Mackinlay
- A Sorescu
- B A Badertscher
- B Bayus
- B Cornell
- B Roe
- B W Jacobs
- C Hill
- C Hull
- C J Corbett
- D Dougherty
- D Leonard-Barton
- D P Mishra
- E A E Jones
- E Bajo
- E F Fama
- E F Fama
- E Mansfield
- Europa
- F K Pil
- F Verboven
- G Frenette
- G Hundley
- G M Schmidt
- H Huang
- H Lee
- H P Nesvold
- I Maignan
- I Nonaka
- J C Dolley
- J D Hamilton
- J Derwall
- J E Ettlie
- J E Kwoka
- J R Woolridge
- J Rockness
- J Rosenbaum
- J Tirole
- Jan Stallaert
- K B Hendricks
- K B Hendricks
- K B Hendricks
- K M Gilley
- K M Kelm
- K Pauwels
- K S Cameron
- L Chan
- L Gaines
- L K Mathur
- L Klomp
- Ling Lei Lisic
- M Book
- M H Kutner
- M I Kamien
- M J Roy
- M Mone
- M Montoya-Weiss
- M Mussa
- M Porter
- M Russo
- M Talay
- N Walley
- O Salzmann
- P Drucker
- P Geroski
- P K Chaney
- P Kennedy
- P Portney
- P S Koku
- Qindong Liu
- R Ball
- R Ball
- R Casadesus-Masanell
- R D Klassen
- R Garcia
- R Lache
- R Lache
- R V Hoed
- S B Brunnermeier
- S C Vance
- S Das
- S H Chan
- S Hart
- S Holak
- S J Brown
- S J Brown
- S Konar
- S Myers
- S S Chen
- S Srinivasan
- Sulin Ba
- T Bresnahan
- T Bresnahan
- V Avagyan
- V Krishnan
- V Lane
- W E Souder
- W F Long
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
Enzyme Handbook
- Author
- 339-349
- [10]Siffert O., Emöd, I.
- [11] Fricker L.D., Snyder, S.H.
- [11] Taylor A., Volz, K.W., Lipscomb, W.N., Takemoto, L. J.
- [3] Schmidt U., Weller, D., Holder, A.
- [9]Fujiwara K., Tsuru, D.
- [hie J.N., Dure, L.S.
- A Amory
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- Chan. S.A.T., Jones, T.H.D., Sweeney, J.P., Toursarkissian, K.
- Chih-Min Kam Fujikawa, K.
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- Xin-Ii Lin Wong, R.N.S., Tang, J.
- Y Agrawal
- Y Agrawal
- Y Atsumi
- Y Bai
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- Y Birk
- Y Dasarathy
- Y Dupont
- Y Ethoh
- Y Etoh
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- Y Hojima
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- Y Isowa
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- Y Kawaguchi
- Y Kido
- Y Kido
- Y Kim
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- Y Levin
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- Y Minami
- Y Miura
- Y Mizuno
- Y Mukohata
- Y Nagai
- Y Nagai
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- Y Nishimura
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- “ (Turk V., Neville, M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1991
- Field of study