Триасовый нефтегазоносный комплекс – потенциальный объект для прироста ресурсной базы Западной Сибири

The paper considers the results of analysis of information on the distribution of the Triassic deposits on the Western Siberia territory. It was established that the Triassic deposits are at different stages of catagenesis. Analysis of sediments distribution allowed defining that the highest potential for oil content is at the central and southern parts, and for gas at the northern area. It is assumed that the deep-seated Triassic deposits at the north of Western Siberia may be considered as a new potential gas-bearing object.Приводятся данные о распространении триасовых отложений на территории Западной Сибири. В связи с тем, что триасовые отложения находятся на разных стадиях катагенеза, установлена следующая закономерность: нефтеносны ее центральная и южная части, а газоносна – северная. Сделано предположение о том, что глубокопогруженные триасовые отложения севера Западной Сибири могут быть новым потенциальным газоносным объектом

Бронхиальная астма: федеральные клинические рекомендации по диагностике и лечению

Bronchial asthma is a heterogeneous disease that requires identification of its phenotype and a personalized approach to therapy. At the same time, despite a wide range of therapeutic options, many patients with asthma cannot achieve control over the disease.Methodology. The target audience of these clinical recommendations are general practitioners, therapists, pediatricians, allergologists-immunologists, pulmonologists, and functional diagnostics doctors. Each thesis-recommendation about diagnostic and therapeutic procedures has been scored according to the scales of classes of recommendations from 1 to 5 and A, B, C scale of the levels of evidence. The clinical recommendations also contain comments and explanations to the theses, algorithms for the diagnosis and treatment of bronchial asthma, and reference materials.Conclusion. The presented clinical guidelines cover current information about the etiology and pathogenesis, classification, clinical manifestations, diagnosis, treatment, and prevention of bronchial asthma. These guidelines were approved by the Scientific and Practical Council of the Ministry of Health of the Russian Federation in 2021. Бронхиальная астма (БА) является гетерогенным заболеванием, при котором требуется выделение различных фенотипов и персонифицированный подход к терапии. При этом несмотря на широкий выбор терапевтических возможностей, у многих пациентов с БА не удается достичь контроля над заболеванием.Методы. Целевой аудиторией данных клинических рекомендаций являются врачи общей практики, терапевты, педиатры, аллергологи-иммунологи, пульмонологи и врачи функциональной диагностики. Каждый тезис-рекомендация по проведению диагностических и лечебных мероприятий оценивается по шкалам уровней достоверности доказательств от 1 до 5 и шкале оценки уровней убедительности рекомендаций по категориям А, В, С. Клинические рекомендации содержат также комментарии и разъяснения к указанным тезисам-рекомендациям, алгоритмы по диагностике и лечению БА, справочные материалы.Заключение. По данным представленных клинических рекомендаций освещаются современные сведения об этиологии и патогенезе, классификации, клинических проявлениях, диагностике, лечении и профилактике БА. Клинические рекомендации одобрены Научно-практическим Советом Министерства здравоохранения Российской Федерации (2021).

The influence of bacterial cultures on the conservation of green fodders

Properties of microbial cultures were carefully studied and strains of lactic and propionate bacteria, which meet requirements imposed to the preserving medicines, are chosen. The following strains were selected: Bifidobacterium bifidum N1 as a lyophilizate, Propionibacterium freudenreichii subsp. shermanii - KM 186 in the form of a liquid preparation, Lactobacillus plantarum 8P-A3 in the form of lyophilizate. To obtain this bacterial concentrate, a series of experiments was conducted to select the necessary concentrations and to create the optimal composition of the starter for each type of silicate raw material. A positive result was the absence of extraneous micro flora in the stored biomass after a month. The quality of harvested silage was judged by the content of organic acids in the herbaceous mass. The main indicator of the effectiveness of lactic acid bacteria for leaven is the accumulation of lactic acid, propionic acid - propionic acid. The content of acids in the siloing of the labor-prone (amaranth red in the phase of the milk-wax ripeness, quinoa) and light-sown crops (corn at the beginning of the phase of wax ripeness (end of the phase of milky wax ripeness), sunflower one-year-old oilseed at the beginning of flowering) was determined in accordance with GOST. The high content of lactic and propionic acids guarantees good preservation of the silage. Their low content means a lack of sugars in the mass or indicates that oxygen penetrates into the mass

¹⁸F-fluoroethyltyrozine positron emission tomography combined with computed tomography and computed tomography perfusion in complex diagnostic of glial brain tumors

The study objective is to evaluate the diagnostic capabilities of complex method based on the use of 18 F-fluoroethyltyrozine positron emission tomography (PET) combined with computed tomography (CT) and CT perfusion in the differential diagnosis of glial brain tumors.Materials and methods. One hundred and two patients with glial brain tumors were included in the study. Depending on the degree of malignancy patients were divided into 2 groups: group 1–38 (37.26 %) patients with grade I–II tumors; group 2–64 (62.74 %) patients with grade III–IV tumors. Perfusion CT was performed in 20 (52.6 %) patients from the group with grade I–II tumors and 37 (57.8 %) patients from the group with grade III–IV gliomas. The sensitivity and specificity of such indicators as the maximum standardized uptake value (maxSUV) and the tumor to brain ratio (TBR), in combination with CT perfusion indicators (cerebral blood flow (CBF), cerebral blood volume (CBV), vascular permeability (FED) were studied.Results. The highest diagnostic accuracy was demonstrated by the following parameters: maxSUV 1 (sensitivity and specificity 81 and 82 %, threshold value 2.51, AUC 0.87); TBR 1 (sensitivity and specificity 90.6 and 81.6 %, threshold value 2.07, AUC 0.89). The comprehensive evaluation of CT perfusion and 18 F-fluoroethyltyrozine PET / CT parameters: sensitivity and specificity of TBR 1 + CBF – 97.1 and 94.4 %, respectively; TBR 1 + CBV – 96.6 and 94.4 %, respectively; TBR 1 + FED – 94.6 and 92.3 %, respectively.Conclusion. According to results of obtained analysis, an increase in diagnostic accuracy was revealed for all studied parameters with complex use of two methods – 18 F-fluoroethyltyrozine PET / CT and CT perfusion, in differential diagnosis of glial brain tumors

18F-PSMA-1007 POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY IN THE DIAGNOSIS OF RECURRENT PROSTATE CANCER: CLINICAL OBSERVATION

Objective: demonstration of possibilities of 18F-prostate specific membrane antigen-1007 (18F-PSMA-1007) positron emission tomography/computed tomography (PET/CT) for diagnostic prostate cancer recurrence.The article presents clinical observation of the patient with prostate cancer biochemical recurrence after the multiple treatment. 18F-PSMA-1007 PET/CT demonstrates high sensitivity in prostate cancer recurrence diagnostic, in particular with low prostatic specific antigen level