What do cells actually want?

Genome-scale models require an objective function representing what an organism strives for. A method has been developed to infer this fundamental biological function from data.Please see related Research article: www.dx.doi.org/10.1186/s13059-016-0968-2

Orientations of hamiltonian cycles in large digraphs

We prove that, with some exceptions, every digraph with n ≥ 9 vertices and at least (n - 1) (n - 2) + 2 arcs contains all orientations of a Hamiltonian cycle

Subjective evaluation of an emerging theory of low-frequency sound source localization in closed acoustic spaces

An earlier reported theory of low-frequency sound-source localization within closed acoustic spaces proposed that virtual image acuity is strongly dependent on sufficient inter-arrival time between a direct sound and its first reflection. This current study aims to test the theory’s predictions by subjective experiment where participants are required to indicate perceived sound source direction, but without knowledge of loudspeaker location. Test signals of frequencies 40 Hz to 115 Hz take the form of either windowed sine or square waves. Results confirm broad agreement with theoretical expectations and support the conjecture, contrary to common expectation, that low-frequency sound localization within the context of closed acoustic spaces is possible, although strongly dependent on system configuration and size of a listening space

Low-frequency sound source localization as a function of closed acoustic spaces

Further development of an emerging generalized theory of low-frequency sound localization in closed listening spaces is presented that aims to resolve the ambiguities inherent in previous research. The approach takes a robust set of equations based on source/listener location, reverberation time and room dimensions and tests them against a set of evaluation procedures to explore image location against theoretical expectations. Phantom imaging is germane to the methodology and its match within the theoretical framework is investigated. Binaural recordings are used to inspect a range of closed environments for localization clues each with a range of source-listener placements. A complementary series of small-scale listening tests are included for perceptual validation

Asteroids in GALEX: Near-ultraviolet photometry of the major taxonomic groups

We present ultraviolet photometry (NUV band, 180--280 nm) of 405 asteroids observed serendipitously by the Galaxy Evolution Explorer (GALEX) from 2003--2012. All asteroids in this sample were detected by GALEX at least twice. Unambiguous visible-color-based taxonomic labels (C type versus S type) exist for 315 of these asteroids; of these, thermal-infrared-based diameters are available for 245. We derive NUV-V color using two independent models to predict the visual magnitude V at each NUV-detection epoch. Both V models produce NUV-V distributions in which the S types are redder than C types with more than 8-sigma confidence. This confirms that the S types' redder spectral slopes in the visible remain redder than the C types' into the NUV, this redness being consistent with absorption by silica-containing rocks. The GALEX asteroid data confirm earlier results from the International Ultraviolet Explorer, which two decades ago produced the only other sizeable set of UV asteroid photometry. The GALEX-derived NUV-V data also agree with previously published Hubble Space Telescope (HST) UV observations of asteroids 21 Lutetia and 1 Ceres. Both the HST and GALEX data indicate that NUV band is less useful than u band for distinguishing subgroups within the greater population of visible-color-defined C types (notably, M types and G types).Comment: 13 pages, 11 figures, accepted 2015-May-6 to The Astrophysical Journal. Includes one machine-readable table of NUV asteroid detections. Version 2 includes a corrected citation to Waszczak et al. (2015) arXiv abstrac

Semileptonic decays of the Higgs boson at the Tevatron

We examine the prospects for extending the Tevatron reach for a Standard Model Higgs boson by including the semileptonic Higgs boson decays h --> WW --> l nu jj for M_h >~ 2 M_W, and h --> W jj --> l nu jj for M_h <~ 2 M_W, where j is a hadronic jet. We employ a realistic simulation of the signal and backgrounds using the Sherpa Monte Carlo event generator. We find kinematic selections that enhance the signal over the dominant W+jets background. The resulting sensitivity could be an important addition to ongoing searches, especially in the mass range 120 <~ M_h <~ 150 GeV. The techniques described can be extended to Higgs boson searches at the Large Hadron Collider.Comment: 68 pages, 19 figure