The phenomenon of the home: Metaphysics of the innermost (as illustrated by the modern Russian culture)

The relevance of the problem under study is based on the influence of the expanding globalization processes that affect the view of life of a modern man: the internal balance is lost due to feeling of chaos, rhythm of life and constant changes. In these conditions there is a tendency to de-humanize the living environment, depersonalization of living space and desacralization of human dwelling which leads to re-thinking of the Home that ensures human existence in the world. The purpose of the article is to state the necessity of new understanding of the Home as the phenomenon of culture which would confront the absolute priority of the rational, pragmatic and utilitarian through the notion of “the innermost”, through studying the transformation of the innermost within the historical context and through revealing the dialectics of the innermost and the explicit in living space of the modern culture. The lead method for studying this problem is the interdisciplinary approach that provides the possibility of comprehensive consideration of the results of philosophical, cultural, architectural and other studies. The article reveals the essence and the main philosophical-cultural characteristics of the Home and the essence of the innermost as a special super-value, specifies the traditional image of the innermost in living space related to the Home as the centre of existence and reveals the attributes of transformation of the innermost in the Home resulting from the processes which are characteristic of the modern age. The materials of the article can be useful for developing the scientific-methodological support of general and special courses, for conducting lessons in philosophical-cultural disciplines and for usage for designing and modeling the living environment. © 2016 Shupletsova et al

Nonlinear features of the transition of a liquid crystalline mixture into an isotropic state under the action of alcohol vapors

The work of an optical sensor for determining the concentration of alcohols, in particular methanol, ethanol and isopropanol, based on a liquid crystal sensitive element, was studied. The sensitive element is a mixture of cholesteric liquid crystal CB15 and nematic impurity E7. The detection and reaction of the sensitive element to the presence of alcohol vapors is investigated

Vitrification and Glass Transition of Water: Insights from Spin Probe ESR

Three long standing problems related to the physics of water viz, the possibility of vitrifying bulk water by rapid quenching, its glass transition, and the supposed impossibility of obtaining supercooled water between 150 and 233 K, the so-called 'no man's land'of its phase diagram, are studied using the highly sensitive technique of spin probe ESR. Our results suggest that water can indeed be vitrified by rapid quenching, it undergoes a glass transition at \~ 135 K, and the relaxation behavior studied using this method between 165 K and 233 K closely follows the predictions of the Adam-Gibbs model.Comment: 13 pages, 3 figures; results on slow cooled water added; four figures compressed in to thre

Search for Λ6^6_\LambdaH hypernucleus by the 6^6Li(π−,K+)(\pi^-,K^+) reaction at pπ−p_{\pi^-} = 1.2 GeV/cc

We have carried out an experiment to search for a neutron-rich hypernucleus, $^6_{\Lambda}$H, by the $^6$Li($\pi^-,K^+$) reaction at $p_{\pi^-}$ =1.2 GeV/$c$. The obtained missing mass spectrum with an estimated energy resolution of 3.2 MeV (FWHM) showed no peak structure corresponding to the $^6_{\Lambda}$H hypernucleus neither below nor above the $^4_{\Lambda}$H$+2n$ particle decay threshold. An upper limit of the production cross section for the bound $^6_{\Lambda}$H hypernucleus was estimated to be 1.2 nb/sr at 90% confidence level.Comment: 6 pages, 5 figures, published versio

Search for the Θ+\Theta^{+} pentaquark via the π−p→K−X\pi^-p\to K^-X reaction at 1.92 GeV/cc

The $\Theta^+$ pentaquark baryon was searched for via the $\pi^-p\to K^-X$ reaction in a missing-mass resolution of 1.4 MeV/$c^2$(FWHM) at J-PARC. $\pi^-$ meson beams were incident on the liquid hydrogen target with the beam momentum of 1.92 GeV/$c$. No peak structure corresponding to the $\Theta^+$ mass was observed. The upper limit of the production cross section averaged over the scattering angle of 2$^{\circ}$ to 15$^{\circ}$ in the laboratory frame was obtained to be 0.26 $\mu$b/sr in the mass region of 1.51$-$1.55 GeV/$c^2$.The upper limit of the $\Theta^+$ decay width using the effective Lagrangian approach was obtained to be 0.72 MeV/$c^2$ and 3.1 MeV/$c^2$ for $J^P_{\Theta}=1/2^+$ and $J^P_{\Theta}=1/2^-$, respectively.Comment: 5 pages, 3 figures, 1 tabl

On the superconductivity in the system with preformed pairs

We discuss the phenomenology of the superconductivity resulting from the bose condensation of the preformed pairs coexisting with unpaired fermions. We show that this transition is more mean field like than usual bose condensation, i.e. it is characterized by a relatively small value of the Ginzburg parameter. We consider the Hall effect in the vortex flow regime and in the fluctuational regime above $T_c$ and show that in this situation it is much less than in the transition driven entirely by bose condesation but much larger than in a usual superconductivity. We analyse the available Hall data and conclude that this phenomenology describes reasonably well the data in the underdoped materials of $YBaCuO$ family but is not an appropriate description of optimally doped materials or underdoped $LaSrCuO$.Comment: Latex/Revtex file, 2 Postscript figures, 10 page

The analysis of physical, genetic and psychological methods of musculoskeletal system injuries prevention in elite athletes

The article reviews the existing methods of injury prevention in sport currently used in Russia and abroad. The article analyzes therapeutic exercises for injury prevention programs and the possible mechanisms of their action. The authors studied the perspectives of prophylactic exercises for injury prevention. The article presents genetic methods for musculoskeletal system injury prevention. The article raises issues of predisposition to various sports depending on the genotype. In addition, the article describes the psychological aspects of the sport injury prevention, in particular, international experience of the injury psycho-prevention in top-level sports

Intrinsic noise alters the frequency spectrum of mesoscopic oscillatory chemical reaction systems

Mesoscopic oscillatory reaction systems, for example in cell biology, can exhibit stochastic oscillations in the form of cyclic random walks even if the corresponding macroscopic system does not oscillate. We study how the intrinsic noise from molecular discreteness influences the frequency spectrum of mesoscopic oscillators using as a model system a cascade of coupled Brusselators away from the Hopf bifurcation. The results show that the spectrum of an oscillator depends on the level of noise. In particular, the peak frequency of the oscillator is reduced by increasing noise, and the bandwidth increased. Along a cascade of coupled oscillators, the peak frequency is further reduced with every stage and also the bandwidth is reduced. These effects can help understand the role of noise in chemical oscillators and provide fingerprints for more reliable parameter identification and volume measurement from experimental spectra

The interplay of intrinsic and extrinsic bounded noises in genetic networks

After being considered as a nuisance to be filtered out, it became recently clear that biochemical noise plays a complex role, often fully functional, for a genetic network. The influence of intrinsic and extrinsic noises on genetic networks has intensively been investigated in last ten years, though contributions on the co-presence of both are sparse. Extrinsic noise is usually modeled as an unbounded white or colored gaussian stochastic process, even though realistic stochastic perturbations are clearly bounded. In this paper we consider Gillespie-like stochastic models of nonlinear networks, i.e. the intrinsic noise, where the model jump rates are affected by colored bounded extrinsic noises synthesized by a suitable biochemical state-dependent Langevin system. These systems are described by a master equation, and a simulation algorithm to analyze them is derived. This new modeling paradigm should enlarge the class of systems amenable at modeling. We investigated the influence of both amplitude and autocorrelation time of a extrinsic Sine-Wiener noise on: $(i)$ the Michaelis-Menten approximation of noisy enzymatic reactions, which we show to be applicable also in co-presence of both intrinsic and extrinsic noise, $(ii)$ a model of enzymatic futile cycle and $(iii)$ a genetic toggle switch. In $(ii)$ and $(iii)$ we show that the presence of a bounded extrinsic noise induces qualitative modifications in the probability densities of the involved chemicals, where new modes emerge, thus suggesting the possibile functional role of bounded noises

Temperature Control of Fimbriation Circuit Switch in Uropathogenic Escherichia coli: Quantitative Analysis via Automated Model Abstraction

Uropathogenic Escherichia coli (UPEC) represent the predominant cause of urinary tract infections (UTIs). A key UPEC molecular virulence mechanism is type 1 fimbriae, whose expression is controlled by the orientation of an invertible chromosomal DNA element—the fim switch. Temperature has been shown to act as a major regulator of fim switching behavior and is overall an important indicator as well as functional feature of many urologic diseases, including UPEC host-pathogen interaction dynamics. Given this panoptic physiological role of temperature during UTI progression and notable empirical challenges to its direct in vivo studies, in silico modeling of corresponding biochemical and biophysical mechanisms essential to UPEC pathogenicity may significantly aid our understanding of the underlying disease processes. However, rigorous computational analysis of biological systems, such as fim switch temperature control circuit, has hereto presented a notoriously demanding problem due to both the substantial complexity of the gene regulatory networks involved as well as their often characteristically discrete and stochastic dynamics. To address these issues, we have developed an approach that enables automated multiscale abstraction of biological system descriptions based on reaction kinetics. Implemented as a computational tool, this method has allowed us to efficiently analyze the modular organization and behavior of the E. coli fimbriation switch circuit at different temperature settings, thus facilitating new insights into this mode of UPEC molecular virulence regulation. In particular, our results suggest that, with respect to its role in shutting down fimbriae expression, the primary function of FimB recombinase may be to effect a controlled down-regulation (rather than increase) of the ON-to-OFF fim switching rate via temperature-dependent suppression of competing dynamics mediated by recombinase FimE. Our computational analysis further implies that this down-regulation mechanism could be particularly significant inside the host environment, thus potentially contributing further understanding toward the development of novel therapeutic approaches to UPEC-caused UTIs