Trip pattern of low density residential area in semi urban industrial cluster: predictive modeling

This research elucidates the trip pattern of the low-density residential zone in a semi-urban industrial cluster of southwestern Nigeria. These sets of dwellers are often times neglected in the transportation planning process. To achieve the aim of this research, domiciliary information gathering procedure was employed with 0.82 return rates. It was backed up with the focus group discussion method. Data on frequency of trips, per capita trip, modal choice, and socioeconomic and demographic data were collected, collated, and analysed. Accordingly, a predictive model was formulated for the trip pattern of the low-density area. This was achieved with the aid of statistical software SPSS version 21.Consequently, the results of the multiple regression models showed that both monthly income and car ownership had a significant positive influence on the work trip while only car ownership positively influences non-work trip. R2 values of 0.729 and 0.739 were obtained for the descriptive model at 95% confidence level. This established the robustness of the model, the analysis showed that monthly income and car ownership had a significant positive influence on the work trip with an Rsquare value of 0.729 and 0.739 for work and non-work trip respectively. This indicated that household will embark on more trips with an increase in car ownership and monthly income. However, effective transportation planning and traffic infrastructural development were recommended to meet the demands of the increased number of trips daily

MedZIM: Mediation analysis for Zero-Inflated Mediators with applications to microbiome data

The human microbiome can contribute to the pathogenesis of many complex diseases such as cancer and Alzheimer's disease by mediating disease-leading causal pathways. However, standard mediation analysis is not adequate in the context of microbiome data due to the excessive number of zero values in the data. Zero-valued sequencing reads, commonly observed in microbiome studies, arise for technical and/or biological reasons. Mediation analysis approaches for analyzing zero-inflated mediators are still lacking largely because of challenges raised by the zero-inflated data structure: (a) disentangling the mediation effect induced by the point mass at zero; and (b) identifying the observed zero-valued data points that are actually not zero (i.e., false zeros). We develop a novel mediation analysis method under the potential-outcomes framework to fill this gap. We show that the mediation effect of the microbiome can be decomposed into two components that are inherent to the two-part nature of zero-inflated distributions. The first component corresponds to the mediation effect attributable to a unit-change over the positive relative abundance and the second component corresponds to the mediation effect attributable to discrete binary change of the mediator from zero to a non-zero state. With probabilistic models to account for observing zeros, we also address the challenge with false zeros. A comprehensive simulation study and the applications in two real microbiome studies demonstrate that our approach outperforms existing mediation analysis approaches.Comment: Corresponding: Zhigang L

IMPLEMENTING A WEB-BASED IMMUNIZATION SCHEDULE REMINDER FOR POSTNATAL SERVICE DELIVERY

The mortality rate of infants under the age of five is still relatively high in many sub-Sahara African countries like Nigeria. Immunization remains the most crucial and cost-effective public health intervention scheme for protecting children in this region from vaccine-preventable diseases. Immunization, however, is only effective if the nursing mothers keep strict appointment schedules. To this effect, information technology can be leveraged to help in this regard. This paper thus implements a web-based immunization schedule reminder for postnatal service delivery. In order to realize the system, a component-based development approach was used to extend an existing electronic medical record to include the immunization schedule reminder. The resulting system is able to reduce child mortality by reducing the rate of missed appointment schedules. Keywords and phrases: immunization, child mortality, schedule reminder, postnatal service delivery

Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): protocol and statistical analysis plan for a randomized controlled trial.

Background: Postpartum haemorrhage (PPH) is a leading cause of maternal death. Tranexamic acid has the potential to reduce bleeding and a large randomized controlled trial of its effect on maternal health outcomes in women with PPH (The WOMAN trial) is ongoing. We will examine the effect of tranexamic acid on fibrinolysis and coagulation in a subset of WOMAN trial participants. Methods. Adult women with clinically diagnosed primary PPH after vaginal or caesarean delivery are eligible for inclusion in the WOMAN trial. In a sub-group of trial participants, blood samples will be collected at baseline and 30 minutes after the first dose of tranexamic acid or matching placebo.  Our primary objective is to evaluate the effect of tranexamic acid on fibrinolysis. Fibrinolysis will be assessed by measuring D-dimers and by rotational thromboelastometry (ROTEM). Secondary outcomes are international normalized ratio (INR), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, haemoglobin and platelets. We aim to include about 180 women from the University College Hospital, Ibadan in Nigeria. Discussion:  This sub-study of WOMAN trial participants should provide information on the mechanism of action of tranexamic acid in women with postpartum haemorrhage. We present the trial protocol and statistical analysis plan. The trial protocol was registered prior to the start of patient recruitment. The statistical analysis plan was completed before un-blinding. Trial registration: The trial was registered: ClinicalTrials.gov, Identifier NCT00872469 https://clinicaltrials.gov/ct2/show/NCT00872469; ISRCTN registry, Identifier ISRCTN76912190 http://www.isrctn.com/ISRCTN76912190 (Registration date: 22/03/2012)

Relative Effects of Parents’ Occupation, Qualification and Academic Motivation of Wards on Students’ Achievement in Senior Secondary School Mathematics in Ogun State

The importance of mathematics to an individual and the society is clearly beyond debate thus, every individual needs some knowledge of mathematics in order to live a useful life and be an effective member of the society. Despite this impo9rtance role accorded mathematics in the school curriculum, many academically capable students prematurely restrict their educational and career options by discontinuing their mathematical learning early in the high school. The poor results in this subject have continued to be stumbling-blocks in the realization of the educational and employment desire of many candidates because it is a gatekeeper for many careers. This study investigated the relative effects of parents’ occupation, education and academic motivation of wards on students’ achievements in senior secondary school Mathematics in Ogun State, Nigeria. The study employed ex-post facto type of research and the sample was selected using the multistage sampling technique. Two thousand four hundred students from 60 selected schools in nine local government areas within Ogun State, Nigeria were involved and two research instruments namely; Students’ Questionnaire; (r = 0.81) and Mathematics Achievement Test; (r = 0.84) were used. Data were analyzed using multiple regression at .05 level of significance. The result reveals that parents’ education has the highest significant influence on the academic achievement of students in Mathematics while the effect of academic motivation had the least effect among the variables which exerted significant effects on students’ academic achievement in Mathematics. Keywords: Parents’ education; Occupation; Academic Motivation; Achievement

Awareness of Genetic Testing for High-Risk Cancer Among Different Racial Groups in the United States

Background: Genetic testing for high-risk cancer can provide information on personal risk of developing cancer, as well as diagnosis, prognosis and treatment once cancer has been detected. Methods: Data for this study were obtained from the Health Information National Trends (HINTS 5, Cycle 4), conducted among U.S. adults (age ≥ 18 years) from February 24 to June 20, 2020. An equal probability sample of addresses were stratified, and an adult was selected from each household. Data analysis was conducted 3,865 respondents who completed the survey. The primary outcome was awareness of genetic testing for high-risk cancer (GTHC). We used weighted multivariable logistic regression to determine the awareness of genetic testing for high-risk cancer, adjusting for age, gender, race/ethnicity, education, household income, general health status and history of cancer. Results: We found a significant association between race/ethnicity and awareness of GTHC. Non-Hispanic Black and Hispanic respondents were less likely to be aware GTHC, compared to White respondents (Non-Hispanic Black: aOR=0.53; 95%CI: 0.32–0.87. Hispanic: aOR=0.58; 95%CI: 0.36–0.95). The awareness of ancestry testing was also significantly associated with awareness of GTHC (aOR=5.62; 95%CI: 2.95–10.72). Female respondents were more likely to be aware of GTHC compared to males (aOR=1.92; 95%CI: 1.37-2.68), and relative to respondents 50-64 years, those 35-49 years were more likely to be aware of GTHC (aOR=1.92; 95%CI: 1.37-2.68). Conclusion: This cross-sectional study showed less awareness of genetic testing for high-risk cancer among non-Hispanic Black and Hispanic groups, highlighting the need for more health education among minority racial groups

Effect of time of application of spent oil on the growth and performance of maize (Zea mays)

The effect of spent oil pollution on the growth and performance of Zea mays at different stages of growth was investigated in this study. It involved addition of different quantities of spent oil to soils where Zea mays plants at different stages of growth were growing on. The plants showed differential response to quantities of spent oil added to the soils and the times of application. Plants exposed to spent oil pollution one week after germination had the highest level of growth inhibition and the highest chlorophyll content. The leaf area development of the plant was inhibited by the exposure of the plant to spent oil pollution as observed seven weeks after germination. The application of spent oil to the soils three and five weeks, respectively after the germination of the seeds of Z. mays had similar effects on dry matter accumulation of the plant. Statistical differences occur on the growth and performance of the plants exposure to spent oil pollution at different stages of growth (p<0.05, p<0.01 and p<0.001). The results from this study showed that generally Z. mays may suffer greater inhibition of growth and performed poorly when it is exposed to spent oil pollution at tender stage of growth.Key words: Spent oil, time application, growth, performance, Zea mays

Haematological and fibrinolytic status of Nigerian women with post-partum haemorrhage.

BACKGROUND: Early treatment with tranexamic acid reduces deaths due to bleeding after post-partum haemorrhage. We report the prevalence of haematological, coagulation and fibrinolytic abnormalities in Nigerian women with postpartum haemorrhage. METHODS: We performed a secondary analysis of the WOMAN trial to assess laboratory data and rotational thromboelastometry (ROTEM) parameters in 167 women with postpartum haemorrhage treated at University College Hospital, Ibadan, Nigeria. We defined hyper-fibrinolysis as EXTEM maximum lysis (ML) > 15% on ROTEM. We defined coagulopathy as EXTEM clot amplitude at 5 min (A5)  1.5. RESULTS: Among the study cohort, 53 (40%) women had severe anaemia (haemoglobin< 70 g/L) and 17 (13%) women had severe thrombocytopenia (platelet count < 50 × 109/L). Thirty-five women (23%) had ROTEM evidence of hyper-fibrinolysis. Based on prothrombin ratio criteria, 16 (12%) had coagulopathy. Based on EXTEM A5 criteria, 49 (34%) had coagulopathy. CONCLUSION: Our findings suggest that, based on a convenience sample of women from a large teaching hospital in Nigeria, hyper-fibrinolysis may commonly occur in postpartum haemorrhage. Further mechanistic studies are needed to examine hyper-fibrinolysis associated with postpartum haemorrhage. Findings from such studies may optimize treatment approaches for postpartum haemorrhage. TRIAL REGISTRATION: The Woman trial was registered: NCT00872469; ISRCTN76912190 (Registration date: 22/03/2012)

Physicochemical Quality and Genotoxic Potential of Wastewater Generated by Canteen Complex

Canteens generate high volumes of wastewater that should constantly be subjected to physicochemical and genotoxicity screening. In this study, the wastewater generated by a canteen complex was screened for physicochemical properties and genotoxic potential using standard procedures and Allium cepa chromosome assay. Results showed that the wastewater had total suspended solids, total dissolved solids, and total hardness concentrations of 120.70 mg/l, 554.50 mg/l, and 500.00 mg/l, respectively. The chloride concentration of the wastewater (7873.60 mg/l) was much higher than the recommended limit of 250 mg/l. The wastewater inhibited root growth in A. cepa at 0.1%, 1%, 10%, 25%, 50%, and 100% concentrations but promoted root growth at 2% and 5% concentrations. The wastewater was highly mitodepressive, with mitotic inhibition generally increasing with rising concentrations. The major chromosomal aberrations observed in A. cepa exposed to different concentrations of canteen wastewater were vagrant, sticky, and bridged chromosomes. No chromosomal aberration was observed in onion roots exposed to water (control). The differences in total chromosomal aberrations across wastewater concentrations were not statistically significant (P &gt; 0.05). In view of these results, the practice of discharging untreated canteen wastewater into drainage canals may not be environmentally sustainable

Dentine hypersensitivity: real or imagined

Background: Dentine hypersensitivity is a common presentation of cause of pain and or discomfort with mastication which has been shown to affect the quality of life of the affected individual. It is also a common cause of presentation at the dental clinics. However, the cause, diagnosis and possible management to give relief can be a dilemma for the clinician who at times may wonder if the sensation the individual is presenting with, is real or imagined.Aim: The purpose of this paper was to review dentine hypersensitivity in view of causes, diagnosis and management.Methodology: Articles used were found by searching the key words: dentine hypersensitivity, tooth wear lesions, desensitization, gingival recession, treatment of hypersensitivity.Result: There are a variety of causes of dentine hypersensitivity with a variety of ways to manage and provide adequate treatment, but the condition must be well understood.Conclusion: Many options of treatment are now available to eliminate the pain from dentine hypersensitivity and thus improving the quality of life of these patients because the sensitivity they experience is real.Keywords: dentine, hypersensitivity, tooth wear, desensitization, quality of lif