Woodrow Wilson: A Failure of Leadership - A Broken Middle East

President Woodrow Wilson failed to engage and lead the Great Powers at the Paris Peace Conference in 1919, thereby missing the opportunity to influence and shape the eventual outcomes of their far-reaching policy decisions. Had he been more effective there, many of the dysfunctions in the Middle East may well not exist today

Do Successive Preterm Births Increase the Risk of Postpartum Depressive Symptoms?

Background. Postpartum depression and preterm birth (PTB) are major problems affecting women’s health. PTB has been associated with increased risk of postpartum depressive symptoms (PDS). However, it is unclear if PTB in women with a prior history of PTB is associated with an incremental risk of PDS. This study aims to determine if PTB in women with a prior history of PTB is associated with an incremental risk of PDS. Methods. Data come from the 2009–2011 national Pregnancy Risk Assessment Monitoring System. Study sample included 55,681 multiparous women with singleton live births in the index delivery. Multiple logistic regression was used to examine the association between PTB and PDS. Results. The risk of PDS was 55% higher in women with PTB in both deliveries (aRR = 1.55; 95% CI = 1.28–1.88) and 74% higher in women with PTB in the index delivery only (aRR = 1.74; 95% CI = 1.49–2.05), compared to women with term deliveries. Conclusions. Preterm birth is a risk factor for PDS. PTB in women with a prior history of PTB is not associated with an incremental risk of PDS. Routine screening for PDS should be conducted for all women and closer monitoring should be done for high risk women with PTB

Factors Associated with Preferences Regarding Selected Forms of Variable Pay: A Replication and Extension

This study investigates the relationships among being paid via different variable pay systems, perceptions regarding selected work environment characteristics, and preferences regarding selected variable pay plans. The data highlight the importance of studying pay system preferences among those with significant work experience because measurement of such variables as experience with variable pay systems and perceptions of work environment characteristics is otherwise not possible. The findings suggest a link between perceptions of work autonomy, efficient management of firm resources and job support, pay satisfaction, experience with variable pay systems and preferences regarding selected variable pay systems

TRADE LIBERALIZATION AS A VEHICLE FOR ADAPTING TO GLOBAL WARMING

This study assesses the potential interaction between climate change and agricultural trade policies. We distinguish between two dimensions of agricultural trade policy: market insulation and subsidy levels. Building on the previous work of Tsigas, Frisvold and Kuhn (1997) we find that, in the presence of current levels of agricultural subsidies, increased price transmission- as called for under the Uruguay Round Agreement on Agriculture- reduces global welfare in the wake of climate change. this is due to the positive correlation between productivity changes and current levels of agricultural support. Increases in subsidized output under climate change tend to exacerbate inefficiencies in the global agricultural economy in the absence of market insulation. However, once agricultural subsidies have also been eliminated, price transmission via the global trading system contributes positively to economic adaptation under climate change.Environmental Economics and Policy, International Relations/Trade,

Mortality in the North Dublin Union During the Great Famine

Responsibility for the tremendous excess mortality associated with the Great Irish Famine of 1846-51 is a continuing topic of debate. One view blames an inadequate government response for much of the tragedy. These debates are hampered by a lack of detailed information on how well relief efforts performed at a local level. Excess mortality ranged from one quarter of the entire population in parts of the west to negligible levels along much of the eastern coastline. Much of this cross-section variation reflects relative wealth. But another theme in the historiography stresses the importance of sympathetic or negligent local figures such as a landlord or priest. This study addresses the question of local agency with a case study of the North Dublin Union, the administrative unit responsible for administering the Irish poor law in the northern half of Dublin city and some adjacent parishes. North Dublin Union is unusual for the quality of its surviving administrative records. We use those records to study the Union's day-to-day functioning during the famine and to estimate mortality rates in the workhouse during the crisis. We find that the tremendous mortality of the North Dublin workhouse inmates during the famine primarily reflects the crisis outside the workhouse's walls; the guardians and managers did reasonably well in preserving human life under these trying circumstances.Ireland, famine, mortality, workhouses

Neuronal plasticity: cell-based strategy for target identification and validation

While growing neurites are relatively plastic during development, their plasticity levels drop rapidly as neurons mature and become integrated into neuronal networks. As a consequence, the central nervous system ability to reorganize itself in response to injury or disease is insufficient. One of the main limitations for the design of therapeutic strategies to enhance neurite sprouting following neurological diseases is our poor understanding of the mechanisms underlying neurite structural plasticity. 

To overcome this limitation, we have implemented a strategy to identify, characterize and validate the most therapeutically relevant drug targets to modulate neuronal plasticity. This strategy is based on the hypothesis that the molecular regulation of the neurite shaft (controlling its ability to sprout) shares similarities with other cell systems. In an initial selection step (1), candidate targets are identified from the literature based on predetermined criteria (e.g. involvement in cell migration and growth cone collapse). (2) Compounds acting on those targets are tested in a neuronal cell-based assay for their effects on neurite sprouting as well as for early detection of undesired effects. (3) The selected targets are further analyzed during a verification step where their subcellular expression and activity is assessed. The regulation of the activity of the potential targets by branching factors is also determined at this point. (4) Once the biological relevance has been established, the signalling pathway in which the potential targets operates within neurons is mapped using activity reporters to uncover additional potential targets. 

This candidate approach, combined with the use of primary neurons, is designed to increase the probability of identifying suitable targets at the same time that it minimizes costs and time to validation. By using this strategy, we have been able to identify a set of proteins controlling neuronal sprouting together with an unsuspected mechanism of regulation of structural plasticity in neurons