The Effect of Pulling Out Cochlear Implant Electrodes on Inner Ear Microstructures: A Temporal Bone Study

The exchange of an cochlear implant or the re-positioning of an electrode have become more frequently required than a decade ago. The consequences of such procedures at a microstructural level within the cochlea are not known. It was the aim of the present study to further investigate the effects of an CI electrode pull-out. Therefore 10 freshly harvested temporal bones (TB) were histologically evaluated after a cochlear implant electrode pull-out of a perimodiolar electrode. In additional 9 TB the intrascalar movements of the CI electrode while being pulled-out were digitally analysed by video- capturing. Histologically, a disruption of the modiolar wall or the spiral osseous lamina were not observed. In one TB, a basilar membrane lifting up was found, but it could not be undoubtedly attributed to the pull-out of the electrode. When analyzing the temporal sequence of the electrode movement during the pull-out, the electrode turned in one case so that the tip elevates the basilar membrane. The pull- out of perimodiolarly placed CI electrodes does not damage the modiolar wall at a microstructural level and should be guided (e.g., forceps) to prevent a 90 o turning of the electrode tip into the direction of the basilar membrane

The semisolid bolus swallow test for clinical diagnosis of oropharyngeal dysphagia: a prospective randomised study

Contrary to clinical experience, clinical swallow tests are predominantly performed using water (water swallow tests, WST). In this study, we examine whether swallow tests performed using a bolus of semisolid food (bolus swallow test, BST) offer benefits. In a prospective, randomised, blind study, the results of a standardised saliva swallow test (SST), WST, BST, combinations of these tests and an endoscopic swallow test (FEES) in patients with oropharyngeal swallowing disorders of neurological (NEU) and non-neurological (NNEU) origin were compared. Sensitivity, specificity, test accuracy and inter-rater reliability were analysed. 62 patients (mean age = 64.68; range = 22–84) were included in the study (NEU = 40; NNEU = 22). A sensitivity of 70.7% (NEU = 70.3%, NNEU = 71.4%) and specificity of 82.5% (NEU = 92.3%; NNEU = 100%) were determined for the WST. The BST + SST was found to have a sensitivity of 89.6% (NEU = 66.7%; NNEU = 90.9%) and a specificity of 72.7% (NEU = 87.5%; NNEU = 90.9%). Analysis of test accuracy showed a statistically significant correlation between FEES and BST + SST. Only BST + SST exhibited statistically significant inter-rater reliability. BST in combination with SST was the sensitive clinical instrument for detecting aspiration both over the patient population as a whole and over the two sub-populations. Inter-rater reliability was found to be statistically significant. The results presented here demonstrate the benefit of semisolid food in investigating clinical dysphagia

AMADEUS: Towards the AutoMAteD secUrity teSting

The proper configuration of systems has become a fundamental factor to avoid cybersecurity risks. Thereby, the analysis of cyber security vulnerabilities is a mandatory task, but the number of vul nerabilities and system configurations that can be threatened is ex tremely high. In this paper, we propose a method that uses software product line techniques to analyse the vulnerable configuration of the systems. We propose a solution, entitled AMADEUS, to enable and support the automatic analysis and testing of cybersecurity vulnerabilities of configuration systems based on feature models. AMADEUS is a holistic solution that is able to automate the analy sis of the specific infrastructures in the organisations, the existing vulnerabilities, and the possible configurations extracted from the vulnerability repositories. By using this information, AMADEUS generates automatically the feature models, that are used for rea soning capabilities to extract knowledge, such as to determine attack vectors with certain features. AMADEUS has been validated by demonstrating the capacities of feature models to support the threat scenario, in which a wide variety of vulnerabilities extracted from a real repository are involved. Furthermore, we open the door to new applications where software product line engineering and cybersecurity can be empowered.Ministerio de Ciencia, Innovación y Universidades RTI2018-094283-B-C33 (ECLIPSE)Junta de Andalucía P20-01224 (COPERNICA)Junta de Andalucía US-1381375 (METAMORFOSIS

Breathing synchronized electrical stimulation of the abdominal muscles in patients with acute tetraplegia

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively

Earliest Query Answering for Deterministic Nested Word Automata

International audienceEarliest query answering (EQA) is an objective of many recent streaming algorithms for XML query answering, that aim for close to optimal memory management. In this paper, we show that EQA is infeasible even for a small fragment of Forward XPath except if P=NP. We then present an EQA algorithm for queries and schemas defined by deterministic nested word automata (dNWAs) and distinguish a large class of dNWAs for which streaming query answering is feasible in polynomial space and time

Maximal atmospheric neutrino mixing and the small ratio of muon to tau mass

We discuss the problem of the small ratio of muon mass to tau mass in a class of seesaw models where maximal atmospheric neutrino mixing is enforced through a $\mu$--$\tau$ interchange symmetry. We introduce into those models an additional symmetry $T$ such that $m_\mu = 0$ in the case of exact $T$ invariance. The symmetry $T$ may be softly broken in the Higgs potential, and one thus achieves $m_\mu \ll m_\tau$ in a technically natural way. We speculate on a wider applicability of this mechanism.Comment: 10 pages, plain LaTeX, no figures, minor changes, final version for J. Phys.

Arbitrary Choice of Basic Variables in Density Functional Theory. II. Illustrative Applications

Our recent theory (Ref. 1) enables us to choose arbitrary quantities as the basic variables of the density functional theory. In this paper we apply it to several cases. In the case where the occupation matrix of localized orbitals is chosen as a basic variable, we can obtain the single-particle equation which is equivalent to that of the LDA+U method. The theory also leads to the Hartree-Fock-Kohn-Sham equation by letting the exchange energy be a basic variable. Furthermore, if the quantity associated with the density of states near the Fermi level is chosen as a basic variable, the resulting single-particle equation includes the additional potential which could mainly modify the energy-band structures near the Fermi level.Comment: 27 page

Initiation of electric discharge. Method of covering the electrode

A report of our experiences involving the treatment six male patients with a new method of closing perforations in the pharynx and upper esophagus, following surgery of the cervical spine region. Perforation of the pharynx and upper esophagus are rare complications following cervical spine surgery. The grave consequences of these complications necessitate in most cases immediate surgical therapy. In most cases, the first step involves the removal of the cervical plate and screws. The defect was then closed using a vascular pedicled musculofascia flap derived from the infrahyoid musculature. In all cases, the flap healed into place without complications. The patients began taking oral nutrients after an average of seven postoperative (5–12) days. In none of the cases did functional disorders or complications arise during the follow-up period (1–5 years). The infrahyoid muscle flap is well suited for reconstruction of the posterior pharyngeal wall and the upper esophagus